Review
Pharmacology & Pharmacy
Roberta Giordo, Anna Maria Posadino, Arduino Aleksander Mangoni, Gianfranco Pintus
Summary: An intricate interplay between genetic and environmental factors contributes to the development of type 2 diabetes (T2D) and its complications. Metformin, a derivative of biguanide, exerts pleiotropic effects through multiple epigenetic modifications, which are reported in various organs, tissues, and cellular compartments. This review discusses the emerging evidence regarding metformin-mediated epigenetic modifications, their significance, potential applications, and future research directions.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Review
Dermatology
Chang Zeng, Lam C. Tsoi, Johann E. Gudjonsson
Summary: The incidence of psoriasis is increasing over time, with recent studies pointing towards the importance of epigenetic modifications in its pathogenesis. Aberrant epigenetic patterns, including changes in DNA methylation, histone modifications and non-coding RNA expression, are observed in psoriatic skin. Reversing these epigenetic mechanisms has shown promise in improving psoriatic phenotypes, making epigenetic therapy a potential avenue for treating psoriasis.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Genetics & Heredity
Jinkun Xia, Wangsen Cao
Summary: Studies show that epigenetic modifications affect the Klotho gene in renal diseases, impacting disease progression. Lowered Klotho levels worsen the condition, but beneficial changes can be made through epigenetic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Plant Sciences
Rocio Nunez-Vazquez, Benedicte Desvoyes, Crisanto Gutierrez
Summary: Plants have developed various mechanisms to adapt to abiotic stresses, which involve transcriptional regulation and chromatin modifications. Understanding and manipulating these regulatory networks are crucial for enhancing crop resilience and performance against stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Genetics & Heredity
Barbara Cugalj Kern, Katarina Trebusak Podkrajsek, Jernej Kovac, Robert Sket, Barbara Jenko Bizjan, Tine Tesovnik, Marusa Debeljak, Tadej Battelino, Natasa Bratina
Summary: Long-term hyperglycemia caused by type 1 diabetes has a significant impact on epigenetic marks in late complications, such as DNA methylation, histone modifications, and microRNAs.
Review
Biochemistry & Molecular Biology
Nina Sopel, Janina Muller-Deile
Summary: Epigenetic modifications can alter gene expression through various mechanisms such as DNA methylation and histone modifications. This review focuses on the role of epigenetic changes in gene regulation, particularly in renal diseases, and highlights the potential of using the zebrafish model for studying epigenetics and discovering novel therapeutic targets. The zebrafish model offers a high-throughput screening tool to identify epigenetic alterations contributing to disease and test new substances for changing epigenetic signatures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Manoela D. Martins, Felipe Martins Silveira, Marco A. T. Martins, Luciana O. Almeida, Vanderlei S. Bagnato, Cristiane H. Squarize, Rogerio M. Castilho
Summary: The study demonstrated that PBMT can accelerate epithelial migration and chromatin relaxation, increase histone acetylation levels, and control stem cell fate, leading to an accelerated healing phenotype.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Cell Biology
Yoshitaka Kubota, Hidekazu Nagano, Kentaro Kosaka, Hideyuki Ogata, Akitoshi Nakayama, Masataka Yokoyama, Kazutaka Murata, Shinsuke Akita, Motone Kuriyama, Nobutaka Furuyama, Masayuki Kuroda, Tomoaki Tanaka, Nobuyuki Mitsukawa
Summary: Ceiling culture-derived preadipocytes (ccdPAs) and adipose-derived stem cells (ASCs) were isolated from human subcutaneous fat tissue and showed differences in adipogenic potential due to variations in methylation and histone modification levels of adipogenesis-related genes, such as PPARc, fatty acid-binding protein 4, and leptin. Genomewide epigenetic analysis revealed distinct patterns in CpG methylation and H3K4me3 modification between ccdPAs and ASCs, suggesting epigenetic mechanisms underlying adipogenic differentiation capabilities of these cell types.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Review
Cell Biology
Qian Xiang, Yongzhao Zhao, Jialiang Lin, Shuai Jiang, Weishi Li
Summary: This study systematically discusses the different epigenetic modifications and their potential functions in the process of spinal ligament aging.
AGEING RESEARCH REVIEWS
(2022)
Review
Oncology
Riya Su, Xinlin Wu, Liang Tao, Changshan Wang
Summary: Distant metastasis is the main cause of the high mortality rate in colorectal cancer (CRC). Research has found that some epigenetic enzymes are often dysregulated or mutated in multiple tumor types, prompting us to study their roles in CRC metastasis. Existing data suggests that targeting epigenetic enzymes is a promising strategy for treating CRC metastasis.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Review
Biochemistry & Molecular Biology
Dominik Franciszek Dluski, Ewa Wolinska, Maciej Skrzypczak
Summary: Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance that appears or is diagnosed for the first time during pregnancy. Studies have shown that GDM can impact both pregnancy and offspring development, leading to long-term adverse health outcomes. Epigenetic changes such as histone modification, DNA methylation, and altered ncRNA function, including miRNAs, play a role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Jing Zhang, Long-Min Chen, Yuan Zou, Shu Zhang, Fei Xiong, Cong-Yi Wang
Summary: Type 1 diabetes (T1D) is an autoimmune disease caused by severe destruction of insulin-producing beta cells, with both genetic predisposition and environmental factors playing critical roles in its pathogenesis. Epigenetics serves as a bridge linking T1D risk genes and environmental exposures, modulating gene expression relevant to T1D development beyond DNA sequence changes.
CHINESE MEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Zihang Huang, Shuai Song, Xiaokai Zhang, Linqi Zeng, Aijun Sun, Junbo Ge
Summary: This review summarizes the impact of cardiac metabolism disorder on histone modifications and gene expression, as well as the dual role of metabolic substrates in regulating cardiac hypertrophy. The article suggests the therapeutic supplementation of metabolic substrates as a potential approach to restore histone modifications.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2023)
Article
Chemistry, Multidisciplinary
Shaista Rahimi, Mahendra P. Singh, Jeena Gupta
Summary: Effluents from textile dyeing industry pose a threat to water pollution, and a study investigated the toxic effects of disperse textile dyes on important enzymes in Drosophila larvae, revealing alterations in antioxidant enzyme activities as a potential mechanism for toxicity.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Akhand Mani, Kriti Kushwaha, Navneet Khurana, Jeena Gupta
Summary: The study found that p-coumaric acid can reduce blood glucose levels in high-fat diet-induced type 2 diabetic rats, improve kidney function, decrease kidney weight, and possess antioxidant properties. It has the potential to prevent diabetic nephropathy by reducing oxidative stress and can serve as a potential drug target for pharmaceutical companies.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2022)
Article
Dermatology
Araiz Ali, Jeena Gupta
Summary: This article summarizes the different types of stem cells present in the skin and the role of adipose-derived stem cells (ADSCs) in providing various anti-aging properties. ADSCs have been found to be useful in skin regeneration, soft tissue augmentation, anti-aging therapy, treating wrinkles, skin whitening, and even in cosmetic surgeries.
CURRENT DERMATOLOGY REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Hayder Mutter Al-kuraishy, Ali Ismail Al-Gareeb, Gomaa Mostafa-Hedeab, Rupal Dubey, Pranav Kumar Prabhakar, Gaber El-Saber Batiha
Summary: COVID-19 is caused by the SARS-CoV-2 virus, which has infected over 245.37 million people and caused over 4.9 million deaths globally. Diabetes mellitus (DM) and its complications are major health concerns with a high growth rate, affecting one in 11 adults and projected to reach 642 million cases by 2040. DM and its complications are associated with the severity and mortality of COVID-19, and the infection may worsen existing cardiovascular conditions in older individuals.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Aayushi Velingkar, Sugunakar Vuree, Pranav Kumar Prabhakar, Rajender Rao Kalashikam, Aparna Banerjee, Suresh Kondeti
Summary: FGF21 is an endocrine hormone that controls metabolic processes and induces glucose transporters synthesis in fat cells. It is expressed in multiple organs and tissues and acts as a regulator of glucose homeostasis by downregulating PPAR. This study highlights the pleiotropic role of FGF21 and its potential as a biomarker and treatment for metabolic and cardiovascular disorders.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Sourbh Suren Garg, Jeena Gupta
Summary: Poorly soluble drugs often degrade in the gastrointestinal tract, limiting their effectiveness. Oral administration faces barriers like acidic pH and presence of microflora and enzymes. Choosing a polymer that can stabilize and release the drug to its target site has been a challenge. Guar gum-based nanoformulations have been extensively used to improve drug delivery and minimize degradation risk, making them highly important.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
Pranav Kumar Prabhakar, Navneet Khurana, Manish Vyas, Vikas Sharma, Gaber El-Saber Batiha, Harpreet Kaur, Jashanpreet Singh, Deepak Kumar, Neha Sharma, Ajeet Kaushik, Raj Kumar
Summary: Coronavirus, belonging to the coronaviridae family, has caused various diseases such as SARS-CoV-2, MERS-CoV-2, and COVID-19. In response to the COVID-19 pandemic, nanotechnology-based vaccines have been developed to aid in the detection, diagnosis, and treatment of the disease.
Article
Endocrinology & Metabolism
Sourbh Suren Garg, Kriti Kushwaha, Rupal Dubey, Jeena Gupta
Summary: Obesity, a metabolic disorder, increases the risk for various diseases including metabolic inflammation, insulin resistance, and cardiovascular diseases. However, the mechanisms linking obesity with other metabolic diseases are not completely understood.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Review
Medicine, Legal
Sweta Kumari, Biplab Pal, Sanjeev Kumar Sahu, Pranav Kumar Prabhakar, Devesh Tewari
Summary: Clenbuterol, a potent beta-2 agonist, is widely misused by athletes, despite the lack of evidence for its performance-enhancing effects. This systematic review evaluated the adverse events associated with clenbuterol among athletes. 23 studies were included, and the most commonly occurring adverse events were cardiac-related complications.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2023)
Article
Chemistry, Physical
Deepshikha Patle, Navneet Khurana, Jeena Gupta, Paranjeet Kaur, Gopal L. Khatik
Summary: Natural products can be structurally modified to achieve desired biological effects, and they are considered safer, cheaper, and more easily accessible compared to synthetic drugs. This research synthesized coixol-based derivatives that may serve as effective antidiabetic agents. In vitro and in vivo experiments demonstrated that compound 14a and 34 have potential for treating Type-II diabetes.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Endocrinology & Metabolism
C. P. Bineesh, M. V. Vimal, Vipin Viswanath, Pranav Kumar Prabhakar
Summary: This study evaluated the levels of adiponectin, leptin, and resistin in prediabetes subjects and found a relationship between these adipokines and insulin resistance. The study results showed that obese prediabetes patients had decreased adiponectin levels, increased leptin and resistin levels, and a decreased adiponectin-leptin ratio. The findings suggest that the adipokine profile can be a useful diagnostic tool for predicting prediabetes and metabolic syndrome in individuals with insulin resistance.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2023)
Editorial Material
Endocrinology & Metabolism
Ponnurengam Malliappan Sivakumar, Ram Prasad, Pranav Kumar Prabhakar
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Chemistry, Applied
Anush Nazar, Jasmin Anush, Riju Mathew, Pranav Kumar Prabhakar
Summary: This article discusses the clinical utility of small dense low-density lipoproteins (sdLDL) as an early marker to predict atherosclerosis and cardiovascular diseases (CVDs), and why it is considered superior to other atherosclerotic markers.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)
Article
Chemistry, Applied
Rupal Dubey, Pranav Kumar Prabhakar, Jeena Gupta
Summary: Diabetes Mellitus is a rapidly increasing metabolic disorder with delayed wound healing as a major complication. Quercetin, a flavonoid, has been found to enhance diabetic wound healing by increasing the expression of SIRT1. In this study, similarity searching and molecular docking were performed to identify compounds similar to Quercetin. Gossypetin and herbacetin were found to have similar binding modes and energy as Quercetin, validating the hypothesis. Further in vitro and in vivo studies are needed to validate the potential of Gossypetin and Herbacetin in improving diabetic wound healing.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)
