Integrating in vitro metabolomics with a 96-well high-throughput screening platform

An automated and high-throughput-screening compatible pluripotent stem cell-based test platform for developmental and reproductive toxicity assessment of small molecule compounds

(2020) Gesa Witt et al.   CELL BIOLOGY AND TOXICOLOGY

struct: an R/Bioconductor-based framework for standardized metabolomics data analysis and beyond

(2020) Gavin Rhys Lloyd et al.   BIOINFORMATICS

Substantial Extracellular Metabolic Differences Found Between Phylogenetically Closely Related Probiotic and Pathogenic Strains of Escherichia coli

(2019) Justin J. J. van der Hooft et al.   Frontiers in Microbiology

A high throughput imaging database of toxicological effects of nanomaterials tested on HepaRG cells

(2019) Elisabeth Joossens et al.   Scientific Data

Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

(2019) Mark R. Viant et al.   Nature Communications

Metabolomics as read-across tool: An example with 3-aminopropanol and 2-aminoethanol

(2019) S. Sperber et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Toxicity testing in the 21st century: progress in the past decade and future perspectives

(2019) D. Krewski et al.   ARCHIVES OF TOXICOLOGY

High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds

(2018) Mattia Zampieri et al.   Science Translational Medicine

A review of nanoscale LC-ESI for metabolomics and its potential to enhance the metabolome coverage

(2018) Andrew J. Chetwynd et al.   TALANTA

Metabolomics profiling of steatosis progression in HepaRG ® cells using sodium valproate

(2018) Matthias Cuykx et al.   TOXICOLOGY LETTERS

Untargeted metabolomics reveals a new mode of action of pretomanid (PA-824)

(2018) Rafael Baptista et al.   Scientific Reports

In vitro assessment of hepatotoxicity by metabolomics: a review

(2018) Matthias Cuykx et al.   ARCHIVES OF TOXICOLOGY

High-throughput screening and environmental risk assessment: State of the science and emerging applications

(2018) Daniel L. Villeneuve et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

A complete workflow for high-resolution spectral-stitching nanoelectrospray direct-infusion mass-spectrometry-based metabolomics and lipidomics

(2017) Andrew D Southam et al.   Nature Protocols

Towards quantitative mass spectrometry-based metabolomics in microbial and mammalian systems

(2016) Rahul Vijay Kapoore et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Metabolomics as read-across tool: A case study with phenoxy herbicides

(2016) B. van Ravenzwaay et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

In vitro kinetics of amiodarone and its major metabolite in two human liver cell models after acute and repeated treatments

(2015) Giuliana Pomponio et al.   TOXICOLOGY IN VITRO

Metabolomics analysis of the toxicity pathways of triphenyl phosphate in HepaRG cells and comparison to oxidative stress mechanisms caused by acetaminophen

(2015) Nele Van den Eede et al.   TOXICOLOGY IN VITRO

Review: Toxicometabolomics

(2013) Mounir Bouhifd et al.   JOURNAL OF APPLIED TOXICOLOGY

High content hepatotoxicity screening based on mode-of-action approach

(2012) Milena Mennecozzi et al.   TOXICOLOGY LETTERS

High-Throughput, Accurate Mass Metabolome Profiling of Cellular Extracts by Flow Injection–Time-of-Flight Mass Spectrometry

(2011) Tobias Fuhrer et al.   ANALYTICAL CHEMISTRY

Spectral relative standard deviation: a practical benchmark in metabolomics

(2008) Helen M. Parsons et al.   ANALYST

A new approach to toxicity testing in Daphnia magna: application of high throughput FT-ICR mass spectrometry metabolomics

(2008) Nadine S. Taylor et al.   Metabolomics

High-throughput tissue extraction protocol for NMR- and MS-based metabolomics

(2007) Huifeng Wu et al.   ANALYTICAL BIOCHEMISTRY