标题
Strategies for late phase preclinical and early clinical trials of senolytics
作者
关键词
Senolytics, Fisetin, Dasatinib, Quercetin, Unitary Theory of Fundamental Aging Processes, Translational Geroscience Network
出版物
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 200, Issue -, Pages 111591
出版商
Elsevier BV
发表日期
2021-10-25
DOI
10.1016/j.mad.2021.111591
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Senolytics: Potential for Alleviating Diabetes and Its Complications
- (2021) Allyson K Palmer et al. ENDOCRINOLOGY
- Senolytics reduce coronavirus-related mortality in old mice
- (2021) Christina D. Camell et al. SCIENCE
- Discovery, Development, and Future Application of Senolytics: Theories and Predictions
- (2020) Erin O. Wissler Gerdes et al. FEBS Journal
- Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
- (2020) Yonghan He et al. Nature Communications
- Senolytic drugs: from discovery to translation
- (2020) J. L. Kirkland et al. JOURNAL OF INTERNAL MEDICINE
- Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
- (2020) Jasper Iske et al. Nature Communications
- Senescence and the SASP: many therapeutic avenues
- (2020) Jodie Birch et al. GENES & DEVELOPMENT
- Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
- (2019) Jamie N. Justice et al. EBioMedicine
- Targeting senescent cells alleviates obesity‐induced metabolic dysfunction
- (2019) Allyson K. Palmer et al. AGING CELL
- Aged-senescent cells contribute to impaired heart regeneration
- (2019) Fiona C. Lewis-McDougall et al. AGING CELL
- Cellular Senescence: Aging, Cancer, and Injury
- (2019) Arianna Calcinotto et al. PHYSIOLOGICAL REVIEWS
- Senescent cell clearance by the immune system: Emerging therapeutic opportunities
- (2019) Larissa G.P. Langhi Prata et al. SEMINARS IN IMMUNOLOGY
- Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
- (2019) LaTonya J. Hickson et al. EBioMedicine
- A versatile drug delivery system targeting senescent cells
- (2018) Daniel Muñoz‐Espín et al. EMBO Molecular Medicine
- Senolytics improve physical function and increase lifespan in old age
- (2018) Ming Xu et al. NATURE MEDICINE
- Fisetin is a senotherapeutic that extends health and lifespan
- (2018) Matthew J. Yousefzadeh et al. EBioMedicine
- Senescence and aging: Causes, consequences, and therapeutic avenues
- (2017) Domhnall McHugh et al. JOURNAL OF CELL BIOLOGY
- Targeting cellular senescence prevents age-related bone loss in mice
- (2017) Joshua N Farr et al. NATURE MEDICINE
- Senescent cells: an emerging target for diseases of ageing
- (2017) Bennett G. Childs et al. NATURE REVIEWS DRUG DISCOVERY
- Cellular senescence mediates fibrotic pulmonary disease
- (2017) Marissa J. Schafer et al. Nature Communications
- Cellular Senescence: A Translational Perspective
- (2017) James L. Kirkland et al. EBioMedicine
- Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
- (2016) Carolyn M. Roos et al. AGING CELL
- Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
- (2016) Yi Zhu et al. AGING CELL
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- (2015) Jianhui Chang et al. NATURE MEDICINE
- Cellular senescence in aging and age-related disease: from mechanisms to therapy
- (2015) Bennett G Childs et al. NATURE MEDICINE
- Targeting senescent cells enhances adipogenesis and metabolic function in old age
- (2015) Ming Xu et al. eLife
- Geroscience: Linking Aging to Chronic Disease
- (2014) Brian K. Kennedy et al. CELL
- Autophagy and the immune function in aging
- (2014) Ana Maria Cuervo et al. CURRENT OPINION IN IMMUNOLOGY
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches
- (2012) Irina M. Conboy et al. CELL CYCLE
- Ageing as a Risk Factor for Disease
- (2012) Teresa Niccoli et al. CURRENT BIOLOGY
- AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
- (2011) Antero Salminen et al. AGEING RESEARCH REVIEWS
- Oncogene-induced senescence: the bright and dark side of the response
- (2010) Vassilis G Gorgoulis et al. CURRENT OPINION IN CELL BIOLOGY
- Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence
- (2009) O. Moiseeva et al. MOLECULAR AND CELLULAR BIOLOGY
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