期刊
MEAT SCIENCE
卷 181, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.meatsci.2021.108611
关键词
OMICs; Proteome; pH; DFD; meat color; Cattle; Muscle structure; TCA cycle; Metabolism; Mitochondria
资金
- Meat Technology Ireland [TC 2016 002]
- [713654]
The comprehensive characterization of the post-mortem muscle proteome sets a fundamental goal in meat proteomics. Proteomics tools have been utilized in foodomics to decipher meat quality variations, with a focus on dark-cutting beef. Various proteomics studies on cattle have investigated the changes in the post-mortem muscle proteome related to dark-cutting beef development. The results of this study provide insights into the major biological pathways underlying dark-cutting beef at the proteome level.
Comprehensive characterization of the post-mortem muscle proteome defines a fundamental goal in meat proteomics. During the last decade, proteomics tools have been applied in the field of foodomics to help decipher factors underpinning meat quality variations and to enlighten us, through data-driven methods, on the underlying mechanisms leading to meat quality defects such as dark-cutting meat known also as dark, firm and dry (DFD) meat. In cattle, several proteomics studies have focused on the extent to which changes in the post-mortem muscle proteome relate to dark-cutting beef development. The present data-mining study firstly reviews proteomics studies which investigated dark-cutting beef, and secondly, gathers the protein biomarkers that differ between dark-cutting versus beef with normal-pH in a unique repertoire. A list of 130 proteins from eight eligible studies was curated and mined through bioinformatics for Gene Ontology annotations, molecular pathways enrichments, secretome analysis and biological pathways comparisons to normal beef color from a previous meta-analysis. The major biological pathways underpinning dark-cutting beef at the proteome level have been described and deeply discussed in this integromics study.
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