Review
Endocrinology & Metabolism
Mao-Qiang Man, Joan S. Wakefield, Theodora M. Mauro, Peter M. Elias
Summary: Epidermal function is influenced by various exogenous and endogenous factors, and changes in epidermal function in type 2 diabetes could exacerbate cutaneous inflammation. Therefore, improving epidermal function could be an alternative approach to mitigating type 2 diabetes and associated skin disorders.
JOURNAL OF DIABETES
(2022)
Article
Multidisciplinary Sciences
Chao-Chun Yang, Yun-Yo Yen, Chao-Kai Hsu, Nan-Yu Cheng, Shih-Yu Tzeng, Shih-Jay Chou, Jun-Ming Chang, Sheng-Hao Tseng
Summary: This study investigated near infrared spectroscopic features of psoriatic and normal skin, revealing significant differences that could be linked to the epidermal barrier function. It was found that using diffuse reflectance spectroscopy could achieve objective evaluation of the epidermal barrier function of psoriasis.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Alexander A. Merleev, Stephanie T. Le, Claire Alexanian, Atrin Toussi, Yixuan Xie, Alina Marusina, Steven M. Watkins, Forum Patel, Allison C. Billi, Julie Wiedemann, Yoshihiro Izumiya, Ashish Kumar, Ranjitha Uppala, J. Michelle Kahlenberg, Fu-Tong Liu, Iannis E. Adamopoulos, Elizabeth A. Wang, Chelsea Ma, Michelle Y. Cheng, Halani Xiong, Amanda Kirane, Guillaume Luxardi, Bogi Andersen, Lam C. Tsoi, Carlito B. Lebrilla, Johann E. Gudjonsson, Emanual Maverakis
Summary: This study characterized the biogeographic alterations of human epidermal lipids across different body sites and compared the gene expression of keratinocytes. The findings highlight the unique adaptation of the epidermis to environmental insults and the impact of inflammation-associated gene expression changes on the epidermal lipidome.
Article
Multidisciplinary Sciences
Daniela Kovacs, Emanuela Bastonini, Stefania Briganti, Monica Ottaviani, Andrea D'Arino, Mauro Truglio, Lorenzo Sciuto, Marco Zaccarini, Alessia Pacifico, Carlo Cota, Paolo Iacovelli, Mauro Picardo
Summary: Vitiligo is a skin depigmentation disease caused by multiple mechanisms, with abnormalities in cells and lipids, and inflammatory mediators secreted by keratinocytes may activate immune responses.
Article
Biology
Trinidad Montero-Vilchez, Carlos Cuenca-Barrales, Juan-Angel Rodriguez-Pozo, Pablo Diaz-Calvillo, Jesus Tercedor-Sanchez, Antonio Martinez-Lopez, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: This study investigated the changes in skin barrier function with age in patients with atopic dermatitis (AD). The results showed that as age increased, AD patients had higher transepidermal water loss (TEWL), lower stratum corneum hydration (SCH), and reduced elasticity compared to healthy individuals. There was a negative correlation between age and elasticity, which was stronger in AD patients than in controls. Linear regression analyses revealed that age and disease severity had a significant impact on elasticity in AD patients. These findings suggest that age plays a role in impairing skin barrier function in AD patients, particularly in terms of elasticity.
Article
Psychiatry
Mao-Qiang Man, Shuyun Yang, Theodora M. Mauro, Guoqiang Zhang, Tingting Zhu
Summary: Autism spectrum disorder (ASD) is a common neurological disorder. Recent studies suggest a link between skin and ASD, indicating the potential role of cutaneous inflammation in ASD pathogenesis.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Dermatology
Burcu Yeni, Alexander Dermietzel, Charalampos Varnava, Philipp Wiebringhaus, Matthias Aitzetmueller, Marie-Luise Klietz, Tobias Hirsch, Maximilian Kueckelhaus
Summary: Researchers have successfully regenerated skin through combined gene and stem cell therapy, and demonstrated its excellent long-term stability. Analysis of biomechanical properties showed significant differences between the transgenic epidermis, non-transgenic skin, and healthy controls. The study suggests potential applications for this technology in treating burns and other conditions.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Article
Dermatology
Burcu Yeni, Alexander Dermietzel, Charalampos Varnava, Philipp Wiebringhaus, Matthias Aitzetmueller, Marie-Luise Klietz, Tobias Hirsch, Maximilian Kueckelhaus
Summary: The study reported the successful regeneration of an entire epidermis through combined gene and stem cell therapy. It also showed the long-term stability of the transgenic epidermis and its potential application in other conditions. The biomechanical properties of the transgenic epidermis demonstrated comparable results to normal skin and healthy controls.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Article
Dermatology
L. Ye, Z. Wang, Y. Kim, P. M. Elias, T. Li, S. Wen, J. Song, C. Lv, B. Yang, M-Q Man
Summary: This study conducted a randomized, open-label pilot trial in two cities in northern China to assess whether improvements in epidermal function can mitigate the progression of cognitive impairment.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marty O. Visscher, Andrew N. Carr, Vivek Narendran
Summary: The development of fetal skin barrier and the immunity of neonatal skin play important roles in protecting against environmental effects and promoting rapid barrier development after birth. Neonatal skin exhibits differences in protein biomarkers, gene expression, and biological processes compared to adult skin, suggesting its unique ability to support the newborn's survival and growth.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Joke A. Bouwstra, Andreea Nadaban, Wim Bras, Clare McCabe, Annette Bunge, Gerrit S. Gooris
Summary: The barrier function of the skin is primarily located in the outermost layer called stratum corneum (SC), which contains lipid lamellae that play a crucial role in permeation of compounds. Analyzing the lipid composition is essential in understanding the skin barrier function and its impairment in inflammatory skin diseases.
PROGRESS IN LIPID RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Alain Lefevre-Utile, Camille Braun, Marek Haftek, Francois Aubin
Summary: The epidermis is a living, multilayered barrier with five functional levels, including physical, chemical, microbial, neuronal, and immune levels, which work together to protect the host from external aggression and maintain its integrity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Dermatology
A. Samadi, T. Yazdanparast, M. Shamsipour, H. Hassanzadeh, M. Hashemi Orimi, R. Firooz, A. Firooz
Summary: This study conducted a systematic review and meta-analysis on the baseline values of stratum corneum hydration in healthy adults, finding that facial skin has higher hydration levels compared to other areas. There were no statistically significant differences in hydration levels between different age groups and genders.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Jan Kottner, Ulrike Blume-Peytavi
Summary: This study examined the reliability and agreement of various skin measurements at the heel and sacral skin areas. It found differences in reliability among the measurements, with transepidermal water loss showing the lowest reliability. Single measurements of skin temperature, stratum corneum, and epidermal hydration can be used in clinical research and practice, while at least two measurements are recommended for estimating transepidermal water loss and erythema. Further evidence is needed to inform researchers about measurement errors in skin and wound research.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Biochemical Research Methods
ChunSik Choe, Johannes Schleusener, JinSong Ri, SeHyok Choe, PokSil Kim, Juergen Lademann, Maxim E. Darvin
Summary: In this study, confocal Raman micro-spectroscopy and tMCR-ALS method were used to quantitatively determine the concentrations of water, lipids, proteins, and topically applied oils in the stratum corneum (SC) by analyzing Raman spectra in the 2000-4000 cm(-1) region.
JOURNAL OF BIOPHOTONICS
(2023)
Review
Chemistry, Medicinal
Anna Ratz-Lyko, Jacek Arct, Slawomir Majewski, Katarzyna Pytkowska
PHYTOTHERAPY RESEARCH
(2015)
Article
Polymer Science
Pawel Tumilowicz, Ludwik Synoradzki, Agnieszka Sobiecka, Jacek Arct, Katarzyna Pytkowska, Slawomir Safarzynski
Article
Chemistry, Multidisciplinary
Jacek Arct, Katarzyna Pytkowska, Marta Pietka
PRZEMYSL CHEMICZNY
(2016)
Article
Polymer Science
Pawel Tumilowicz, Ludwik Synoradzki, Agnieszka Sobiecka, Jacek Arct, Katarzyna Pytkowska, Slawomir Safarzynski
Article
Dermatology
Pawel Tumilowicz, Agata Goliszewska, Jacek Arct, Katarzyna Pytkowska, Marcin Szczepanik
VETERINARY DERMATOLOGY
(2018)
Article
Food Science & Technology
Anna Ratz-Ayko, Anna Herman, Jacek Arct, Katarzyna Pytkowska
FOOD SCIENCE AND BIOTECHNOLOGY
(2014)
Article
Food Science & Technology
Anna Ratz-Lyko, Jacek Arct, Anna Herman, Katarzyna Pytkowska, Slawomir Majewski
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2014)
Article
Dermatology
Anna Ratz-Lyko, Jacek Arct, Katarzyna Pytkowska, Awomir Majewski
JOURNAL OF COSMETIC AND LASER THERAPY
(2015)
Article
Dermatology
Anna Ratz-Lyko, Jacek Arct, Katarzyna Pytkowska
SKIN RESEARCH AND TECHNOLOGY
(2012)
Article
Dermatology
Iwona Bialas, Jacek Arct, Miroslaw Mojski, Stanislaw Krus
SKIN RESEARCH AND TECHNOLOGY
(2012)
Article
Chemistry, Multidisciplinary
Tomasz Wasilewski, Jacek Arct, Katarzyna Pytkowska, Monika Swit-Poplawska, Anita Bocho-Janiszewska, Tomasz Bujak
PRZEMYSL CHEMICZNY
(2015)
Article
Chemistry, Multidisciplinary
Tomasz Wasilewski, Jacek Arct, Katarzyna Pytkowska, Anita Bocho-Janiszewska, Maciej Krajewski, Tomasz Bujak
PRZEMYSL CHEMICZNY
(2015)
Article
Chemistry, Multidisciplinary
Beata W. Domagalska, Katarzyna Pytkowska
PRZEMYSL CHEMICZNY
(2014)
Article
Biotechnology & Applied Microbiology
Anna Ratz-Lyko, Jacek Arct, Katarzyna Pytkowska, Slawomir Majewski, Mateusz Bregisz
FOOD TECHNOLOGY AND BIOTECHNOLOGY
(2013)