Mitochondrial phosphatase PGAM5 regulates Keap1-mediated Bcl-xL degradation and controls cardiomyocyte apoptosis driven by myocardial ischemia/reperfusion injury

Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis

(2016) Wei Lu et al.   PLoS One

Systematic Review of Therapies for Stable Coronary Artery Disease in Diabetic Patients

(2015) Suvitesh Luthra et al.   ANNALS OF THORACIC SURGERY

Redox signalling and cardioprotection: translatability and mechanism

(2015) P Pagliaro et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages

(2015) Kenta Moriwaki et al.   JOURNAL OF IMMUNOLOGY

Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling

(2015) Young Jun Kang et al.   Nature Communications

The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy

(2014) Hao Wu et al.   Autophagy

Reperfusion Strategies in Acute Coronary Syndromes

(2014) Akshay Bagai et al.   CIRCULATION RESEARCH

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy

(2014) Guo Chen et al.   MOLECULAR CELL

Apple pectin, a dietary fiber, ameliorates myocardial injury by inhibiting apoptosis in a rat model of ischemia/reperfusion

(2014) Sun Ha Lim et al.   Nutrition Research and Practice

Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson’s-like movement disorder

(2014) Wei Lu et al.   Nature Communications

Historical Perspective on the Pathology of Myocardial Ischemia/Reperfusion Injury

(2013) Robert B. Jennings   CIRCULATION RESEARCH

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Interaction with Cyclin H/Cyclin-dependent Kinase 7 (CCNH/CDK7) Stabilizes C-terminal Binding Protein 2 (CtBP2) and Promotes Cancer Cell Migration

(2013) Yuchan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of the miR-144/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1

(2012) Xiaohong Wang et al.   CARDIOVASCULAR RESEARCH

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation

(2012) H-Y Lin et al.   CELL DEATH AND DIFFERENTIATION

Overexpression of forkhead box J2 can decrease the migration of breast cancer cells

(2012) Yingying Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Substrates of IAP Ubiquitin Ligases Identified with a Designed Orthogonal E3 Ligase, the NEDDylator

(2012) Min Zhuang et al.   MOLECULAR CELL

Prevention of Apoptosis by Mitochondrial Phosphatase PGAM5 in the Mushroom Body Is Crucial for Heat Shock Resistance in Drosophila melanogaster

(2012) Yosuke Ishida et al.   PLoS One

Inhibitor of Nrf2 (INrf2 or Keap1) Protein Degrades Bcl-xL via Phosphoglycerate Mutase 5 and Controls Cellular Apoptosis

(2011) Suryakant K. Niture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidized DJ-1 Interacts with the Mitochondrial Protein BCL-XL

(2011) Haigang Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis

(2010) S K Niture et al.   CELL DEATH AND DIFFERENTIATION

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

Nrf2 signaling and cell survival

(2009) Suryakant K. Niture et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

(2008) Shih-Ching Lo et al.   EXPERIMENTAL CELL RESEARCH

Heart Disease and Stroke Statistics—2008 Update

(2007) et al.   CIRCULATION

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY