Review
Biochemistry & Molecular Biology
Andras Makkosa, Bence Agg, Balazs Petrovicha, Zoltan V. Varga, Aniko Gorbea, Peter Ferdinandy
Summary: Myocardial ischemia-reperfusion injury and oxidative stress play crucial roles in cardiac pathology by altering RNA transcription and protein function. miRNA expression, affected by oxidative stress, may regulate cytoprotective mechanisms against I/R, and analysis of miRNA-mRNA targets could reveal important mechanisms for cardioprotection.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Filippo Scialo, Alberto Sanz
Summary: Mitochondria are essential for producing energy in cells, but they also generate Reactive Oxygen Species (ROS) which play a critical role in determining cell fate and maintaining cellular homeostasis. Accumulation of defective mitochondria during aging leads to high levels of ROS production, causing oxidative stress and disrupting redox signaling.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Monika Kuczynska, Patrycja Jakubek, Agnieszka Bartoszek
Summary: The concept of oxidative stress and the search for antioxidant-based remedies has gained immense interest. However, commercial success of antioxidants has surpassed research on the exact redox mechanisms that control health and disease states. This review explores the redox network formed by ROS and cellular molecules, and its regulation of genomic and proteomic processes. It also highlights the concept of reductive stress, which is less well-established compared to oxidative stress.
Review
Biochemistry & Molecular Biology
Filip Kolodziej, Brian McDonagh, Nicole Burns, Katarzyna Goljanek-Whysall
Summary: Oxidative stress and inflammation are associated with muscle function decline, but paradoxically, they are also important for adaptive responses to exercise. MicroRNAs play a key role in regulating skeletal muscle metabolism and phenotype. Regular aerobic exercise, accompanied by a healthy diet, can promote metabolic health and muscle hypertrophy through miRNA-mediated regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Plant Sciences
John T. Hancock, David Veal
Summary: NO and other RNS are key signaling molecules in plants, interacting with ROS and H2S. This translation briefly discusses the interactions between these reactive molecules and the influence of intracellular redox on ROSN.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Biochemistry & Molecular Biology
Beatriz Castejon-Vega, Mario D. D. Cordero, Alberto Sanz
Summary: In the past, mtROS were seen as byproducts of cellular metabolism and drivers of ageing and age-related diseases. Now, we know that mtROS serve as important cellular messengers, playing a role in maintaining cellular homeostasis and influencing cellular differentiation, proliferation, and survival. However, dysregulated mtROS signaling can contribute to degenerative diseases. This review focuses on the signaling pathways involving mtROS and their role in ageing.
Article
Biochemistry & Molecular Biology
Gerd Heusch, Ioanna Andreadou, Robert Bell, Edoardo Bertero, Hans-Erik Botker, Sean M. Davidson, James Downey, Philip Eaton, Peter Ferdinandy, Bernard J. Gersh, Mauro Giacca, Derek J. Hausenloy, Borja Ibanez, Thomas Krieg, Christoph Maack, Rainer Schulz, Frank Sellke, Ajay M. Shah, Holger Thiele, Derek M. Yellon, Fabio Di Lisa
Summary: This review summarizes the roles of reactive oxygen species (ROS) in myocardial ischemia/reperfusion injury and cardioprotection. It emphasizes the need for cardioprotection beyond rapid reperfusion in acute myocardial infarction and discusses the pathomechanisms of myocardial ischemia/reperfusion, different modes of cell death in myocardial infarction, and interventions to protect the ischemic/reperfused myocardium. The second part focuses on ROS, providing an overview of molecular and cellular mechanisms involved in ischemia/reperfusion injury.
Article
Plant Sciences
Wei Quan, Hui-xian Liu, Wei Zhang, Wei-juan Lou, Yang-ze Gong, Chong Yuan, Qing Shao, Na Wang, Chao Guo, Fei Liu
Summary: The study demonstrates that Rosmarinic acid (RosA) can significantly reduce myocardial infarct size, cardiac dysfunction, release of myocardial injury enzymes, cell death, and oxidative stress caused by myocardial ischemia/reperfusion injury.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Plant Sciences
Mohd Saleem, Qazi Fariduddin, Christian Danve M. Castroverde
Summary: Reactive oxygen species (ROS) play important roles in regulating various processes in plants, but over-accumulation can lead to oxidative stress, emphasizing the importance of maintaining redox homeostasis. Salicylic acid (SA) serves as a chief regulator in controlling ROS and antioxidant defense system signaling, yet the underlying mechanisms require further exploration.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Martina Perse
Summary: The paper summarizes the use of cisplatin in mouse models and existing issues, as well as recommendations for improvements in future research, emphasizing the similarities in response to cisplatin treatment between humans and mice.
Review
Plant Sciences
Mark T. Waters, David C. Nelson
Summary: Karrikins (KARs) are compounds found in smoke that stimulate seed germination and regulate various developmental processes in plants. They are evolutionarily related to strigolactones (SLs) and share similarities in signaling systems. The understanding of KAR/KL signaling has advanced significantly, but there are still unanswered questions and controversies in this field.
Article
Mathematics
Wieslaw A. Dudek, Robert A. R. Monzo
Summary: The text discusses properties of pentagonal quasigroups, including multiplication operation, regular automorphism, and specific identity features. Through a series of proofs and classifications, some conclusions and characteristics about pentagonal quasigroups are drawn.
Review
Biochemistry & Molecular Biology
Andrea Huwiler, Karl-Friedrich Beck, Josef Pfeilschifter
Summary: Redox-active mediators are powerful molecules regulating cellular dynamics and gene expression. Reactive oxygen species (ROS), and gasotransmitters such as NO, CO, and H2S, are key mediators, along with sphingolipid molecules. Cross-regulation between redox mediators and sphingolipids influences cell fate and organ function. This review highlights the effects of redox-active mediators on sphingolipid signaling, metabolism, and their impact on pathophysiological processes.
Article
Biochemistry & Molecular Biology
Veronica Lisi, Giorgia Senesi, Nadia Bertola, Matteo Pecoraro, Sara Bolis, Alice Gualerzi, Silvia Picciolini, Andrea Raimondi, Cristina Fantini, Elisa Moretti, Attilio Parisi, Paolo Sgro, Luigi Di Luigi, Roger Geiger, Silvia Ravera, Giuseppe Vassalli, Daniela Caporossi, Carolina Balbi
Summary: Cardiovascular diseases (CVD) can lead to increased reactive oxygen species (ROS) levels and vasoconstriction, resulting in arterial hypertension. Physical exercise (PE) can protect against CVD by reducing ROS levels and increasing antioxidant enzyme expression. This study investigated the role of circulating extracellular vesicles (EVs) after exercise and found that they have antioxidant activity and a cardioprotective effect.
Article
Biochemistry & Molecular Biology
Claudia Lennicke, Helena M. Cocheme
Summary: The study found that oxidants, especially H2O2, can mimic the effects of insulin. Increasing intracellular H2O2 levels affects signaling and amplifies insulin-mediated cellular responses. Specific molecular targets of insulin-stimulated H2O2 include phosphatases and kinases, whose activity is altered through redox modifications.
Editorial Material
Biochemistry & Molecular Biology
Pasquale Pagliaro, Claudia Penna
CURRENT MEDICINAL CHEMISTRY
(2018)
Review
Biochemistry & Molecular Biology
Raffaella Mastrocola, Manuela Aragno, Giuseppe Alloatti, Massimo Collino, Claudia Penna, Pasquale Pagliaro
CURRENT MEDICINAL CHEMISTRY
(2018)
Article
Biotechnology & Applied Microbiology
Jasmin Popara, Lisa Accomasso, Emanuela Vitale, Clara Gallina, Dorotea Roggio, Ambra Lannuzzi, Stefania Raimondo, Raffaella Rastaldo, Gabriele Alberto, Federico Catalano, Gianmario Martra, Valentina Turinetto, Pasquale Pagliaro, Claudia Giachino
Review
Physiology
Gilda Varricchi, Pietro Ameri, Christian Cadeddu, Alessandra Ghigo, Rosalinda Madonna, Giancarlo Marone, Valentina Mercurio, Ines Monte, Giuseppina Novo, Paolo Parrella, Flora Pirozzi, Antonio Pecoraro, Paolo Spallarossa, Concetta Zito, Giuseppe Mercuro, Pasquale Pagliaro, Carlo G. Tocchetti
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Physiology
Carmine Rocca, Saveria Femmino, Giorgio Aquila, Maria C. Granieri, Ernestina M. De Francesco, Teresa Pasqua, Damiano C. Rigiracciolo, Francesca Fortini, Maria C. Cerra, Marcello Maggiolini, Pasquale Pagliaro, Paola Rizzo, Tommaso Angelone, Claudia Penna
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Physiology
Isabella Russo, Saveria Femmino, Cristina Barale, Francesca Tullio, Stefano Geuna, Franco Cavalot, Pasquale Pagliaro, Claudia Penna
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Hans Erik Botker, Derek Hausenloy, Ioanna Andreadou, Salvatore Antonucci, Kerstin Boengler, Sean M. Davidson, Soni Deshwal, Yvan Devaux, Fabio Di Lisa, Moises Di Sante, Panagiotis Efentakis, Saveria Femmino, David Garcia-Dorado, Zoltan Giricz, Borja Ibanez, Efstathios Iliodromitis, Nina Kaludercic, Petra Kleinbongard, Markus Neuhaeuser, Michel Ovize, Pasquale Pagliaro, Michael Rahbek-Schmidt, Marisol Ruiz-Meana, Klaus-Dieter Schlueter, Rainer Schulz, Andreas Skyschally, Catherine Wilder, Derek M. Yellon, Peter Ferdinandy, Gerd Heusch
BASIC RESEARCH IN CARDIOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Teresa Pasqua, Pasquale Pagliaro, Carmine Rocca, Tommaso Angelonel, Claudia Penna
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2018)
Review
Cardiac & Cardiovascular Systems
Coert J. Zuurbier, Antonio Abbate, Hector A. Cabrera-Fuentes, Michael V. Cohen, Massimo Collino, Dominique P. V. De Kleijn, James M. Downey, Pasquale Pagliaro, Klaus T. Preissner, Masafumi Takahashi, Sean M. Davidson
CARDIOVASCULAR RESEARCH
(2019)
Review
Cardiac & Cardiovascular Systems
Sean M. Davidson, Ioanna Andreadou, Lucio Barile, Yochai Birnbaum, Hector A. Cabrera-Fuentes, Michael V. Cohen, James M. Downey, Henrique Girao, Pasquale Pagliaro, Claudia Penna, John Pernow, Klaus T. Preissner, Peter Ferdinandy
CARDIOVASCULAR RESEARCH
(2019)
Article
Physiology
Silvana Roberto, Raffaele Milia, Azzurra Doneddu, Virginia Pinna, Girolamo Palazzolo, Stefano Serra, Andrea Orru, Seyed Alireza Hosseini Kakhak, Giovanna Ghiani, Gabriele Mulliri, Pasquale Pagliaro, Antonio Crisafulli
JOURNAL OF APPLIED PHYSIOLOGY
(2019)
Editorial Material
Physiology
Mariarosaria Santillo, Pasquale Pagliaro
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Cell & Tissue Engineering
Caterina Cristallini, Giuseppe Vaccari, Niccoletta Barbani, Elisa Cibrario Rocchietti, Rossella Barberis, Mimmo Falzone, Karine Cabiale, Giovanni Perona, Elena Bellotti, Raffaella Rastaldo, Silvia Pascale, Pasquale Pagliaro, Claudia Giachino
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2019)
Review
Biochemistry & Molecular Biology
Carlo Gabriele Tocchetti, Christian Cadeddu, Daniela Di Lisi, Saveria Femmino, Rosalinda Madonna, Donato Mele, Ines Monte, Giuseppina Novo, Claudia Penna, Alessia Pepe, Paolo Spallarossa, Gilda Varricchi, Concetta Zito, Pasquale Pagliaro, Giuseppe Mercuro
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Article
Physiology
A. Folino, L. Accomasso, C. Giachino, P. G. Montarolo, G. Losano, P. Pagliaro, R. Rastaldo