标题
Therapeutic anti-CD3 monoclonal antibodies: from bench to bedside
作者
关键词
-
出版物
Immunotherapy
Volume 8, Issue 8, Pages 889-906
出版商
Future Medicine Ltd
发表日期
2016-05-10
DOI
10.2217/imt-2016-0049
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Manipulating regulatory T cells: a promising strategy to treat autoimmunity
- (2015) Dunfang Zhang et al. Immunotherapy
- Oral Administration of OKT3 MAb to Patients with NASH, Promotes Regulatory T-cell Induction, and Alleviates Insulin Resistance: Results of a Phase IIa Blinded Placebo-Controlled Trial
- (2015) Gadi Lalazar et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Heterogeneous CD3 Expression Levels in Differing T Cell Subsets Correlate with the In Vivo Anti-CD3–Mediated T Cell Modulation
- (2015) Andrea Valle et al. JOURNAL OF IMMUNOLOGY
- Regression of atherosclerosis with anti-CD3 antibody via augmenting a regulatory T-cell response in mice
- (2014) Tomoyuki Kita et al. CARDIOVASCULAR RESEARCH
- Low-Dose Otelixizumab Anti-CD3 Monoclonal Antibody DEFEND-1 Study: Results of the Randomized Phase III Study in Recent-Onset Human Type 1 Diabetes
- (2014) Ronnie Aronson et al. DIABETES CARE
- A CD3-Specific Antibody Reduces Cytokine Production and Alters Phosphoprotein Profiles in Intestinal Tissues From Patients With Inflammatory Bowel Disease
- (2014) Anna Vossenkämper et al. GASTROENTEROLOGY
- The importance of regulatory T-cell heterogeneity in maintaining self-tolerance
- (2014) Xiaomei Yuan et al. IMMUNOLOGICAL REVIEWS
- Latency-Associated Peptide Identifies a Novel CD4+CD25+ Regulatory T Cell Subset with TGF -Mediated Function and Enhanced Suppression of Experimental Autoimmune Encephalomyelitis
- (2014) M.-L. Chen et al. JOURNAL OF IMMUNOLOGY
- Nasal Anti-CD3 Antibody Ameliorates Lupus by Inducing an IL-10-Secreting CD4+CD25-LAP+ Regulatory T Cell and Is Associated with Down-Regulation of IL-17+CD4+ICOS+CXCR5+ Follicular Helper T Cells
- (2014) H. Y. Wu et al. JOURNAL OF IMMUNOLOGY
- Suppression of Mature Dendritic Cell Function by Regulatory T Cells In Vivo Is Abrogated by CD40 Licensing
- (2014) J. Hanig et al. JOURNAL OF IMMUNOLOGY
- Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II
- (2014) Bitao Liang et al. JOURNAL OF IMMUNOLOGY
- Oral anti-CD3 immunotherapy for HCV-nonresponders is safe, promotes regulatory T cells and decreases viral load and liver enzyme levels: results of a phase-2a placebo-controlled trial
- (2014) W. Halota et al. JOURNAL OF VIRAL HEPATITIS
- Delayed Anti-CD3 Therapy Results in Depletion of Alloreactive T Cells and the Dominance of Foxp3+CD4+Graft Infiltrating Cells
- (2013) R. Goto et al. AMERICAN JOURNAL OF TRANSPLANTATION
- TGF-β Activation and Function in Immunity
- (2013) Mark A. Travis et al. Annual Review of Immunology
- Anti-cytokine therapies in T1D: Concepts and strategies
- (2013) Gerald T. Nepom et al. CLINICAL IMMUNOLOGY
- Teplizumab (Anti-CD3 mAb) Treatment Preserves C-Peptide Responses in Patients With New-Onset Type 1 Diabetes in a Randomized Controlled Trial: Metabolic and Immunologic Features at Baseline Identify a Subgroup of Responders
- (2013) K. C. Herold et al. DIABETES
- Teplizumab Preserves C-Peptide in Recent-Onset Type 1 Diabetes: Two-Year Results From the Randomized, Placebo-Controlled Protege Trial
- (2013) W. Hagopian et al. DIABETES
- Efficacy and safety of low-dose otelixizumab anti-CD3 monoclonal antibody in preserving C-peptide secretion in adolescent type 1 diabetes: DEFEND-2, a randomized, placebo-controlled, double-blind, multi-centre study
- (2013) P. Ambery et al. DIABETIC MEDICINE
- Regulatory T cells in nonlymphoid tissues
- (2013) Dalia Burzyn et al. NATURE IMMUNOLOGY
- Therapeutic Use of a Selective S1P1 Receptor Modulator Ponesimod in Autoimmune Diabetes
- (2013) Sylvaine You et al. PLoS One
- Generation and Function of Induced Regulatory T Cells
- (2013) Erica G. Schmitt et al. Frontiers in Immunology
- Potent Induction Immunotherapy Promotes Long-Term Insulin Independence After Islet Transplantation in Type 1 Diabetes
- (2012) M. D. Bellin et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Induction of Allograft Tolerance by Monoclonal CD3 Antibodies: A Matter of Timing
- (2012) S. You et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance
- (2012) Angelina M. Bilate et al. Annual Review of Immunology
- Long-term amelioration of established collagen-induced arthritis achieved with short-term therapy combining anti-CD3 and anti-tumor necrosis factor treatments
- (2012) Fabien Dépis et al. ARTHRITIS AND RHEUMATISM
- Preexisting Autoantibodies Predict Efficacy of Oral Insulin to Cure Autoimmune Diabetes in Combination With Anti-CD3
- (2012) A. A. Mamchak et al. DIABETES
- An Oral CD3-Specific Antibody Suppresses T-Cell–Induced Colitis and Alters Cytokine Responses to T-Cell Activation in Mice
- (2012) Katharina Forster et al. GASTROENTEROLOGY
- Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice
- (2012) Tatiana Takiishi et al. JOURNAL OF CLINICAL INVESTIGATION
- Teplizumab Induces Human Gut-Tropic Regulatory Cells in Humanized Mice and Patients
- (2012) F. Waldron-Lynch et al. Science Translational Medicine
- Regulatory T-Cells: Diverse Phenotypes Integral to Immune Homeostasis and Suppression
- (2012) Richard A. Peterson TOXICOLOGIC PATHOLOGY
- Report of a Joint ESOT and AST Meeting: Highlights in Biologic Agents and Transplantation
- (2011) C. C. Baan et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Induction of Immunological Tolerance by Oral Anti-CD3
- (2011) Andre Pires da Cunha et al. Clinical & Developmental Immunology
- Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade: Evidence of Improved Immune Regulation
- (2011) V. Ablamunits et al. DIABETES
- Sub-optimal CD4+ T-cell activation triggers autonomous TGF-β-dependent conversion to Foxp3+ regulatory T cells
- (2011) Vanessa G. Oliveira et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Oral tolerance
- (2011) Howard L. Weiner et al. IMMUNOLOGICAL REVIEWS
- Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment
- (2011) Damien Bresson et al. JOURNAL OF AUTOIMMUNITY
- Anti-CD3 Therapy Promotes Tolerance by Selectively Depleting Pathogenic Cells while Preserving Regulatory T Cells
- (2011) C. Penaranda et al. JOURNAL OF IMMUNOLOGY
- Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial
- (2011) Nicole Sherry et al. LANCET
- Control of TH17 cells occurs in the small intestine
- (2011) Enric Esplugues et al. NATURE
- In Vivo Induction of Tr1 Cells via Mucosal Dendritic Cells and AHR Signaling
- (2011) Henry Yim Wu et al. PLoS One
- Human CD3 Transgenic Mice: Preclinical Testing of Antibodies Promoting Immune Tolerance
- (2011) C. Kuhn et al. Science Translational Medicine
- Type 1 regulatory T cells (Tr1) in autoimmunity
- (2011) Caroline Pot et al. SEMINARS IN IMMUNOLOGY
- TGF-β: the sword, the wand, and the shield of FOXP3+ regulatory T cells
- (2011) Dat Q. Tran Journal of Molecular Cell Biology
- Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass
- (2010) B. Keymeulen et al. DIABETOLOGIA
- Acquisition of regulatory function by human CD8+ T cells treated with anti-CD3 antibody requires TNF
- (2010) Vitaly Ablamunits et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis
- (2010) W. J. Sandborn et al. GUT
- Phase I, double-blind, randomized, placebo-controlled, dose-escalation study of NI-0401 (a fully human anti-CD3 monoclonal antibody) in patients with moderate to severe active Crohnʼs disease†
- (2010) Janneke C. van der Woude et al. INFLAMMATORY BOWEL DISEASES
- Mucosal Anti-CD3 Monoclonal Antibody Attenuates Collagen-Induced Arthritis That Is Associated with Induction of LAP+ Regulatory T Cells and Is Enhanced by Administration of an Emulsome-Based Th2-Skewing Adjuvant
- (2010) H. Y. Wu et al. JOURNAL OF IMMUNOLOGY
- Metrics for antibody therapeutics development
- (2010) Janice M. Reichert mAbs
- Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice
- (2010) Y. Ilan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- It takes guts for tolerance: The phenomenon of oral tolerance and the regulation of autoimmune response
- (2009) Jean Pierre Schatzmann Peron et al. AUTOIMMUNITY REVIEWS
- Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients
- (2009) B. Keymeulen et al. BLOOD
- Oral Anti-CD3 Antibody Treatment Induces Regulatory T Cells and Inhibits the Development of Atherosclerosis in Mice
- (2009) Naoto Sasaki et al. CIRCULATION
- Rapamycin Prevents and Breaks the Anti-CD3-Induced Tolerance in NOD Mice
- (2009) A. Valle et al. DIABETES
- Remission of Type 1 Diabetes after Anti-CD3 Antibody Treatment and Transplantation of Embryonic Pancreatic Precursors
- (2009) Salma Begum et al. ENDOCRINOLOGY
- Oral Administration of OKT3 Monoclonal Antibody to Human Subjects Induces a Dose-Dependent Immunologic Effect in T Cells and Dendritic Cells
- (2009) Yaron Ilan et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Dissociation of efficacy and cytokine release mediated by an Fc-modified anti-CD3 mAb in a chronic experimental autoimmune encephalomyelitis model
- (2009) Nicole A. Belmar et al. JOURNAL OF NEUROIMMUNOLOGY
- Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells
- (2009) HY Wu et al. LUPUS
- Visilizumab induces apoptosis of mucosal T lymphocytes in ulcerative colitis through activation of caspase 3 and 8 dependent pathways
- (2008) Qi T. Yu et al. CLINICAL IMMUNOLOGY
- Molecular engineering and design of therapeutic antibodies
- (2008) Leonard G Presta CURRENT OPINION IN IMMUNOLOGY
- Human regulatory T cells: role in autoimmune disease and therapeutic opportunities
- (2008) Todd M. Brusko et al. IMMUNOLOGICAL REVIEWS
- CD4+FoxP3+regulatory T cells confer infectious tolerance in a TGF-β–dependent manner
- (2008) John Andersson et al. JOURNAL OF EXPERIMENTAL MEDICINE
- New immunosuppressive approaches: Oral administration of CD3-specific antibody to treat autoimmunity
- (2008) Hirofumi Ochi et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- CD3-specific antibody–induced immune tolerance involves transforming growth factor-β from phagocytes digesting apoptotic T cells
- (2008) Sylvain Perruche et al. NATURE MEDICINE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started