T-cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases

Association ofTIM-1 5383-5397ins/delandTIM-3 -1541C>T polymorphismswith multiple sclerosis in Isfahan population

(2016) F. Mazrouei et al.   International Journal of Immunogenetics

Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood

(2016) Katrin Klocke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3

(2016) Atsushi Kadowaki et al.   Nature Communications

Blockade of Interferon Beta, but Not Interferon Alpha, Signaling Controls Persistent Viral Infection

(2015) Cherie T. Ng et al.   Cell Host & Microbe

CTLA-4 as a genetic determinant in autoimmune Addison’s disease

(2015) A S B Wolff et al.   GENES AND IMMUNITY

Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients

(2015) Mark R. Rigby et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+T cells

(2015) Pamela M. Odorizzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

(2015) Eoin F. McKinney et al.   NATURE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Overcoming T cell exhaustion in infection and cancer

(2015) Kristen E. Pauken et al.   TRENDS IN IMMUNOLOGY

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

(2015) Prakash K. Gupta et al.   PLoS Pathogens

TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity

(2014) Iona S. Schuster et al.   IMMUNITY

Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection

(2014) Alison Crawford et al.   IMMUNITY

2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+T cell responses

(2014) Danya Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

(2014) Pablo Penaloza-MacMaster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Contributions of Apoptosis and Anergy to Systemic T Cell Tolerance

(2014) L. Barron et al.   JOURNAL OF IMMUNOLOGY

Comment on “Tim-3 Directly Enhances CD8 T Cell Responses to AcuteListeria monocytogenesInfection”

(2014) Vijay K. Kuchroo et al.   JOURNAL OF IMMUNOLOGY

Tim-3 Directly Enhances CD8 T Cell Responses to Acute Listeria monocytogenes Infection

(2014) J. V. Gorman et al.   JOURNAL OF IMMUNOLOGY

Lymphocyte Activation Gene-3 (LAG-3) Negatively Regulates Environmentally-Induced Autoimmunity

(2014) Vibha Jha et al.   PLoS One

Type I Interferon in Human Autoimmunity

(2014) Timothy B. Niewold   Frontiers in Immunology

Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway

(2013) James C. Lee et al.   CELL

Gene Targeting in NOD Mouse Embryos Using Zinc-Finger Nucleases

(2013) Y.-G. Chen et al.   DIABETES

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

(2013) E. B. Wilson et al.   SCIENCE

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

(2013) J. R. Teijaro et al.   SCIENCE

Aberrant Type I Interferon Regulation in Autoimmunity: Opposite Directions in MS and SLE, Shaped by Evolution and Body Ecology

(2013) Anthony T. Reder et al.   Frontiers in Immunology

Clonal Exhaustion as a Mechanism to Protect Against Severe Immunopathology and Death from an Overwhelming CD8 T Cell Response

(2013) Markus Cornberg et al.   Frontiers in Immunology

Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells

(2012) Nir Yogev et al.   IMMUNITY

PD-1 Protects against Inflammation and Myocyte Damage in T Cell-Mediated Myocarditis

(2012) M. L. Tarrio et al.   JOURNAL OF IMMUNOLOGY

The negative costimulatory molecule PD-1 modulates the balance between immunity and tolerance via miR-21

(2011) Dimitrios Iliopoulos et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Blood Relatives of Follicular Helper T Cells

(2011) Carola G. Vinuesa et al.   IMMUNITY

Tight Regulation of Memory CD8+ T Cells Limits Their Effectiveness during Sustained High Viral Load

(2011) Erin E. West et al.   IMMUNITY

Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis

(2011) James C. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients

(2011) Lukas Baitsch et al.   JOURNAL OF CLINICAL INVESTIGATION

PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

(2011) Taku Okazaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: An NK Cell-Independent Role for Slamf4 in Controlling Humoral Autoimmunity

(2011) D. R. Brown et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Accelerated Autoimmune Diabetes in the Absence of LAG-3

(2011) M. Bettini et al.   JOURNAL OF IMMUNOLOGY

Type I interferon signature is high in lupus and neuromyelitis optica but low in multiple sclerosis

(2011) Xuan Feng et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Natural killer cells act as rheostats modulating antiviral T cells

(2011) Stephen N. Waggoner et al.   NATURE

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection

(2011) R. D. Aubert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity

(2011) P. A. Lang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen-Specific Immunotherapy for Type 1 Diabetes: Maximizing the Potential

(2010) M. Peakman et al.   DIABETES

Absence of mouse 2B4 promotes NK cell–mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis

(2010) Stephen N. Waggoner et al.   JOURNAL OF CLINICAL INVESTIGATION

A CD8+ T cell transcription signature predicts prognosis in autoimmune disease

(2010) Eoin F McKinney et al.   NATURE MEDICINE

Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

(2010) Michael Quigley et al.   NATURE MEDICINE

Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular signature of CD8+T cells undergoing deletional tolerance

(2009) Ian A. Parish et al.   BLOOD

Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis

(2009) Edward J Carr et al.   BMC Medical Genetics

Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus

(2009) Elizabeth C. Jury et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Remapping the type I diabetes association of the CTLA4 locus

(2009) H-Q Qu et al.   GENES AND IMMUNITY

Cell-Intrinsic Transforming Growth Factor-β Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence In Vivo

(2009) Roberto Tinoco et al.   IMMUNITY

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

(2009) Soumya Raychaudhuri et al.   NATURE GENETICS

The role of the CD58 locus in multiple sclerosis

(2009) P. L. De Jager et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High antigen levels are the cause of T cell exhaustion during chronic viral infection

(2009) S. N. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection

(2009) J. S. Yi et al.   SCIENCE

IL-21 Is Required to Control Chronic Viral Infection

(2009) H. Elsaesser et al.   SCIENCE

IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection

(2009) A. Frohlich et al.   SCIENCE

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway

(2008) F. Haspot et al.   BLOOD

Association of programmed cell death 1 polymorphisms and systemic lupus erythematosus: a meta-analysis

(2008) YH Lee et al.   LUPUS

Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population

(2008) Akari Suzuki et al.   NATURE GENETICS

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis

(2008) F. Flores-Borja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA