Efficacy and Safety of IV Sildenafil in the Treatment of Newborn Infants with, or at Risk of, Persistent Pulmonary Hypertension of the Newborn (PPHN): A Multicenter, Randomized, Placebo-Controlled Trial

PDE5 inhibitors - pharmacology and clinical applications 20 years after sildenafil discovery

(2018) K-E Andersson   BRITISH JOURNAL OF PHARMACOLOGY

Efficacy of 1, 5, and 20 mg oral sildenafil in the treatment of adults with pulmonary arterial hypertension: a randomized, double-blind study with open-label extension

(2017) Carmine Dario Vizza et al.   BMC Pulmonary Medicine

Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo-Controlled Exploratory Trial

(2016) Robin H. Steinhorn et al.   JOURNAL OF PEDIATRICS

Clinical research in neonates and infants: Challenges and perspectives

(2016) Raffaele Coppini et al.   PHARMACOLOGICAL RESEARCH

Clinical trials of medicines in neonates: the influence of ethical and practical issues on design and conduct

(2015) Mark A. Turner   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Arterial hypotension and prerenal failure in an extremely preterm infant associated with oral sildenafil

(2015) H Balasubramanian et al.   Journal of Perinatology

Global Collaboration to Develop New and Existing Drugs for Neonates

(2015) Jonathan M. Davis et al.   JAMA Pediatrics

Oral sildenafil and inhaled iloprost in the treatment of pulmonary hypertension of the newborn

(2014) Hasan Kahveci et al.   PEDIATRIC PULMONOLOGY

Hydrocortisone Normalizes Phosphodiesterase-5 Activity in Pulmonary Artery Smooth Muscle Cells from Lambs with Persistent Pulmonary Hypertension of the Newborn

(2014) Marta Perez et al.   Pulmonary Circulation

Beyond Pulmonary Hypertension: Sildenafil for Chronic Lung Disease of Prematurity

(2013) Robin H. Steinhorn et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Impact of early surfactant and inhaled nitric oxide therapies on outcomes in term/late preterm neonates with moderate hypoxic respiratory failure

(2013) G G Konduri et al.   Journal of Perinatology

The use of Sildenafil in the Treatment of Persistent Pulmonary Hypertension of the Newborn: A Review of the Literature

(2012) Nicoletta Iacovidou et al.   CURRENT PHARMACEUTICAL DESIGN

The Use of Sildenafil in Persistent Pulmonary Hypertension of the Newborn

(2009) Arturo Vargas-Origel et al.   AMERICAN JOURNAL OF PERINATOLOGY

Intravenous Sildenafil in the Treatment of Neonates with Persistent Pulmonary Hypertension

(2009) Robin H. Steinhorn et al.   JOURNAL OF PEDIATRICS

Population Pharmacokinetics of Sildenafil in Term Neonates: Evidence of Rapid Maturation of Metabolic Clearance in the Early Postnatal Period

(2008) A Mukherjee et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Hyperoxia Increases Phosphodiesterase 5 Expression and Activity in Ovine Fetal Pulmonary Artery Smooth Muscle Cells

(2007) Kathryn N. Farrow et al.   CIRCULATION RESEARCH