Article
Pediatrics
Kevin Le Duc, Thameur Rakza, Jean Benoit Baudelet, Mohamed Riadh Boukhris, Sebastien Mur, Ali Houeijeh, Laurent Storme
Summary: This study aimed to evaluate the application of Tissue Doppler Imaging in assessing right and left cardiac function in newborn infants with pulmonary hypertension. The results showed that newborn infants with pulmonary hypertension have marked right ventricular diastolic dysfunction, while left ventricular function is normal. Therefore, we propose that the severity of respiratory failure is related to the degree of right ventricular diastolic dysfunction.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Enhuan Wei, Xiu-hua Chen, Si-Jia Zhou
Summary: This study evaluated the effectiveness of treprostinil and oral sildenafil in managing persistent pulmonary hypertension of newborns (PPHN). The results demonstrated that treprostinil effectively lowered pulmonary artery pressure, improved oxygenation, and corrected shunt direction faster than sildenafil.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pharmacology & Pharmacy
Kevin Le Duc, Sixtine Gilliot, Jean Benoit Baudelet, Sebastien Mur, Mohamed Riadh Boukhris, Olivia Domanski, Pascal Odou, Laurent Storme
Summary: This case highlights the potential fetal and neonatal complications associated with maternal use of topical Diclofenac medication during pregnancy, resulting in antenatal closure of the ductus arteriosus.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Linli Sun, Chunxia Wang, Yulu Zhou, Wei Sun, Chunjiang Wang
Summary: Different doses of sildenafil can significantly improve persistent pulmonary hypertension of the newborn (PPHN), with 1.5 mg/kg showing better clinical efficacy in reducing pulmonary artery systolic pressure, increasing oxygen partial pressure, and reducing carbon dioxide partial pressure.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pediatrics
Ran Zhou, You-Ning Zheng, Xin-Ying Zhang, Ya-Ying Cheng
Summary: Through a meta-analysis of 22 references, a total of 12 risk factors associated with persistent pulmonary hypertension of the newborn were identified, including factors related to pregnant women and newborns. Some of the most important risk factors identified were smoking during pregnancy, gestational weeks < 37, and perinatal asphyxia.
FRONTIERS IN PEDIATRICS
(2021)
Article
Obstetrics & Gynecology
Amber Kamran, Nida Rafiq, Adeel Khalid, Fatima Amin, Veena Kumari, Abdul Sattar Shaikh, Sameer Saleem Tebha, Najma Patel
Summary: This study aimed to evaluate the effectiveness of oral Sildenafil in treating PPHN and found that 52 patients showed improvement after 48 hours, while 30 patients required an increase in Sildenafil dose. Three patients died within 48-72 hours. Overall, oral Sildenafil was effective in treating PPHN, and the combination with Bosentan showed better results in some patients.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Thomas Jack, Julia Carlens, Franziska Diekmann, Hosan Hasan, Philippe Chouvarine, Nicolaus Schwerk, Carsten Mueller, Ivonne Wieland, Igor Tudorache, Gregor Warnecke, Murat Avsar, Alexander Horke, Fabio Ius, Dmitry Bobylev, Georg Hansmann
Summary: A prospective observational study at Hannover Medical School showed that lung transplantation (LuTx) in children with end-stage pulmonary arterial hypertension (PAH) resulted in excellent midterm outcomes with 100% survival at 2 years post-LuTx. Postoperative VA-ECMO support facilitated early extubation and contributed to sustained biventricular reverse-remodeling and improved systolic function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pediatrics
Narongsak Nakwan, Punna Kunhapan, Tassamonwan Chaiyasung, Nusara Satproedprai, Kamonnut Singkhamanan, Surakameth Mahasirimongkol, Chariyawan Charalsawadi
Summary: This study conducted a genome-wide association study (GWAS) to search for genetic variants associated with persistent pulmonary hypertension of the newborn (PPHN) in the Thai population. The results suggested that rs149768622 T>C in the WWC2 gene may be associated with PPHN. However, replication and functional studies are needed to validate this association and explore the role of the WWC2 gene in PPHN.
TRANSLATIONAL PEDIATRICS
(2023)
Article
Obstetrics & Gynecology
Antoine Fakhry AbdelMassih, Fatma Al. Zahraa Hassan, Amira El-Gammal, Mustafa Tawfik, Dina Nabil
Summary: This study investigated ventricular functions in full-term neonates with PPHN and found that both left ventricular and right ventricular dysfunction were present in these patients. The research suggests that left ventricular function may be a better predictor of short-term outcomes in PPHN patients than right ventricular function.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Pediatrics
Steven M. Donn
Summary: This paper reviews the historical aspects of PPHN, providing insights into the progress we have made in treating this condition and the challenges that lie ahead.
SEMINARS IN FETAL & NEONATAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Lili Kang, Xianghong Liu, Zilong Li, XiaoMei Li, Yujie Han, Chen Liu, Cuifen Zhao, Xiaoying Li
Summary: Persistent pulmonary hypertension of the newborn (PPHN) is a condition characterized by pulmonary arterial remodeling due to apoptosis resistance and excessive proliferation of pulmonary artery smooth muscle cells (PASMCs). Sildenafil, a phosphodiesterase-5 inhibitor, has been shown to have protective effects against PPHN. This study demonstrates that sildenafil effectively inhibits PASMC proliferation and apoptosis inhibition induced by hypoxia, reduces cardiac hypertrophy, and inhibits pulmonary vascular remodeling in a PPHN model. Overexpression of Notch3 reverses the effects of sildenafil, while knockdown of Notch3 enhances its effects.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Chuyang Lin, Jiao Mi, Yinyue Zhang, Sichen Duan, Jinlin Wu, Yifei Li
Summary: This study developed a nomogram prediction system for assessing the mortality of newborns with PPHN, identifying plasma pH value, septicemia, and abnormal pregnancy history as independent risk factors for neonatal death in newborns with PPHN. The nomogram predictive model based on multivariate analysis showed sufficient predictive value and calibration.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pediatrics
Elsayed Abdelkreem, Shaimaa M. Mahmoud, Moustafa O. Aboelez, Mohamed Abd El Aal
Summary: The study investigated the effectiveness of nebulized magnesium sulfate in treating persistent pulmonary hypertension of newborns. Results showed that the NebMag group had better outcomes in terms of oxygenation index, mean arterial blood pressure, vasoactive inotropic score, and serum magnesium level compared to the IVMag group. Larger studies are needed to confirm the potential of nebulized magnesium sulfate as a therapeutic modality for neonates with severe PPHN on mechanical ventilation.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Jawad Salman, Beeke-Alina Bernhard, Fabio Ius, Reza Poyanmehr, Wiebke Sommer, Khalil Aburahma, Hani Alhadidi, Thierry Siemeni, Christian Kuehn, Murat Avsar, Axel Haverich, Gregor Warnecke, Igor Tudorache
Summary: This study aimed to identify risk factors for the need of intra-operative ECMO use in lung transplant patients with pulmonary fibrosis. Factors such as preoperative proof of pulmonary hypertension, mean pulmonary arterial pressure, and pulmonary vascular resistance were identified as risk factors, while increased recipient body surface area and higher cardiac output were protective factors. The post-operative course was found to be more complicated in the ECMO+ group, although long-term survival did not differ significantly among groups.
ANNALS OF THORACIC SURGERY
(2021)
Article
Pediatrics
Yuwei Zhao, Lei Liang, Guanghui Liu, Hong Zheng, Liying Dai, Yan Wang, Lei Wang, Weiting Sheng
Summary: From the study, it was found that asphyxia and neonatal respiratory distress syndrome (NRDS) were independent risk factors associated with non-response to iNO therapy in neonates diagnosed with persistent pulmonary hypertension (PPHN).
FRONTIERS IN PEDIATRICS
(2021)
Review
Pediatrics
Lucinda J. Weaver, Colm P. Travers, Namasivayam Ambalavanan, David Askenazi
Summary: This article discusses the impact of excessive fluid accumulation on neonates and its related pathophysiology, and provides clinical recommendations for monitoring, prevention, and treatment of fluid overload.
PEDIATRIC NEPHROLOGY
(2023)
Article
Pediatrics
Jeremy M. Loberger, Ryan M. Jones, Adeline S. Phillips, Jeremy A. Ruhlmann, A. K. M. Fazlur Rahman, Namasivayam Ambalavanan, Priya Prabhakaran
Summary: This study aimed to evaluate the relationship between endotracheal secretions and pediatric extubation failure, and found that the evaluation of secretion character by bedside nurses was independently associated with extubation failure. A model combining other key factors showed good discrimination for predicting extubation outcomes.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Jean Lowe, Janell F. Fuller, Allison G. Dempsey, Barbara Do, Carla M. Bann, Abhik Das, Kathryn E. Gustafson, Betty R. Vohr, Susan R. Hintz, Kristi L. Watterberg
Summary: This study found that a blunted cortisol awakening response is associated with memory and attention problems in preterm children. This has implications for stress reactivity and learning problems in preterm children.
PEDIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Amelia E. Freeman, Kent A. Willis, Luhua Qiao, Ahmed S. Abdelgawad, Brian Halloran, Gabriel Rezonzew, Zoha Nizami, Nancy Wenger, Amit Gaggar, Namasivayam Ambalavanan, Trent E. Tipple, Charitharth Lal
Summary: Bronchopulmonary dysplasia (BPD) is a common lung disease in premature infants caused by hyperoxia exposure and microbial dysbiosis. This study reveals that airway dysbiosis impairs Nrf2-dependent antioxidant function, leading to a more severe phenotype of BPD. Furthermore, supporting colonization with Lactobacillus species to enhance Nrf2-mediated antioxidant activity can improve dysbiotic-augmented lung injury.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Critical Care Medicine
Samuel J. Gentle, Colm P. Travers, Arie Nakhmani, Premananda Indic, Waldemar A. Carlo, Namasivayam Ambalavanan
Summary: Early identification of infants with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) is crucial due to the higher risk of death. We investigated the intermittent hypoxemia (IH) patterns in infants with BPD-PH and compared them with infants with BPD alone. Our findings showed that infants with BPD-PH had longer duration of hypoxemic events, which was associated with both the diagnosis of BPD-PH and death in these infants.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Engineering, Biomedical
Pravinkumar G. Kandhare, Namasivayam Ambalavanan, Colm P. Travers, Waldemar A. Carlo, Nikolay M. Sirakov, Arie Nakhmani
Summary: Prediction of biomedical signal changes is useful for clinical applications, but evaluation and applicability of prediction tools depend on specific clinical contexts. This study proposes a novel method to evaluate and compare vital sign predictors and validates it for rare events scenarios. Experimental results show that simple statistical predictors can outperform state-of-the-art deep learning architectures for low-dimensional signals.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Pediatrics
Vivek V. Shukla, A. K. M. Fazlur Rahman, Xuejun Shen, Allison Black, Nitin Arora, C. Vivek Lal, Edward F. Bell, Arie Nakhmani, Chengcui Zhang, Namasivayam Ambalavanan, Waldemar A. Carlo
Summary: The study evaluated the association between the COVID-19 pandemic and stillbirth and neonatal mortality rates. The findings showed that the neonatal mortality rate decreased during the pandemic periods compared to the baseline period, while the stillbirth rate did not significantly change.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Pravitha Ramanand, Premananda Indic, Colm P. Travers, Namasivayam Ambalavanan
Summary: This study aimed to investigate oxygenation patterns during two types of oxygen supplementation in preterm infants and assess their performance in hypoxemia risk screening during NICU monitoring. The findings showed that oxygen saturation had higher volatility and complexity during digitally-set servo-controlled oxygen environment supplementation. Additionally, variability measures of oxygen saturation exhibited early prognostic value in discriminating infants at higher risk of hypoxemic events. Multivariate models with two features showed good performance in risk stratification.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, Research & Experimental
Bianca M. . Vamesu, Teodora Nicola, Rui Li, Snehashis Hazra, Sadis Matalon, Naftali Kaminski, Namasivayam Ambalavanan, Jegen Kandasamy
Summary: Mitochondrial dysfunction at birth is associated with the development of bronchopulmonary dysplasia (BPD) in extremely low-birth weight (ELBW) infants. Nebulized thyroid hormone (TH) has shown potential to improve mitochondrial function and reduce pulmonary fibrosis in adult animals. This study investigated the effects of intranasal T3 on neonatal lung injury and mitochondrial dysfunction in newborn mice, as well as its impact on lung fibroblasts and mesenchymal stem cells from ELBW infants. The results demonstrated that inhaled T3 attenuated hyperoxia-induced lung injury and improved mitochondrial function in mice, suggesting that TH supplementation might be a valuable therapeutic strategy for BPD.
Article
Medicine, General & Internal
Samuel J. Gentle, Matthew A. Rysavy, Lei Li, Matthew M. Laughon, Ravim. Patel, Erik A. Jensen, Susan Hintz, Namasivayam Ambalavanan, Waldemar A. Carlo, Kristi Watterberg
Summary: In extremely preterm infants, the use of hydrocortisone does not reduce the risk of bronchopulmonary dysplasia or death, nor does it increase the risk of neurodevelopmental impairment or death.
Article
Obstetrics & Gynecology
Angela R. Seasely, Victoria C. Jauk, Jeff M. Szychowski, Namasivayam Ambalavanan, Alan T. Tita, Brian M. Casey
Summary: This study aimed to investigate survival rates and neonatal outcomes following periviable birth, as well as long-term outcomes during hospital admission based on gestational age. The results showed that survival rates increased with advancing gestational age and infants exposed to antenatal corticosteroids had more interventions, less pulmonary hypertension, and improved survival to 1 year of life.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Viral G. Jain, Namasivayam Ambalavanan
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Pediatrics
Debra E. Weese-Mayer, Juliann M. Di Fiore, Douglas E. Lake, Anna Maria Hibbs, Nelson Claure, Jiaxing Qiu, Namasivayam Ambalavanan, Eduardo Bancalari, James S. Kemp, Amanda M. Zimmet, John L. Carroll, Richard J. Martin, Katy N. Krahn, Aaron Hamvas, Sarah J. Ratcliffe, Narayanan Krishnamurthi, Premananda Indic, Alaleh Dormishian, Phyllis A. Dennery, J. Randall Moorman
Summary: The study found that cardioventilatory events peak during the first month of life in extremely preterm infants, but the trajectory afterwards depends on the type of event, race, sex, and use of mechanical ventilation. Apnea, periodic breathing, and intermittent hypoxemia events rose from day 3 of life then fell to near-resolution by 8-12 weeks of age. Apnea and intermittent hypoxemia were inversely correlated with gestational age, while periodic breathing was positively correlated with gestational age.
PEDIATRIC RESEARCH
(2023)
Article
Microbiology
Ahmed Abdelgawad, Teodora Nicola, Isaac Martin, Brian A. Halloran, Kosuke Tanaka, Comfort Y. Adegboye, Pankaj Jain, Changchun Ren, Charitharth V. Lal, Namasivayam Ambalavanan, Amy E. O'Connell, Tamas Jilling, Kent A. Willis
Summary: This study identifies a gut-lung axis driven by intestinal AMP expression and mediated by the intestinal microbiota that is linked to lung injury in newborns. These findings support that intestinal AMPs modulate lung injury and repair.
Article
Psychiatry
Carla M. Bann, Katherine C. Okoniewski, Leslie Clarke, Deanne Wilson-Costello, Stephanie Merhar, Sara DeMauro, Scott Lorch, Namasivayam Ambalavanan, Myriam Peralta-Carcelen, Catherine Limperopoulos, Brenda Poindexter, Jonathan M. Davis, Michele Walsh, Jamie Newman
Summary: This study found that perceived stigma in healthcare settings during pregnancy is associated with psychological distress in the postpartum period. Individuals who reported stigma had higher levels of depression, anxiety, and anger, and lower levels of well-being. They were also more likely to experience food insecurity, adverse childhood experiences, and abuse during pregnancy, and had less emotional support.
ARCHIVES OF WOMENS MENTAL HEALTH
(2023)
