Article
Immunology
Yifan Qu, Xinyi Li, Fengying Xu, Shimin Zhao, Xuemei Wu, Yuzhen Wang, Jiming Xie
Summary: The study demonstrates that kaempferol has significant anti-inflammatory and antioxidant effects in DSS-induced colitis mice, alleviating UC symptoms by modulating the gut microbiota and TLR4-related signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Zhe Xu, Shan-shan Man, Bo-yang Gong, Zhao-dong Li, Hui-fang Zhou, Yan-fei Peng, Shu-wu Zhao, Yun-long Hou, Li Wang, Yu-hong Bian
Summary: This study found that Bazi Bushen has protective effects on SAMP6 mice, improving intestinal inflammation and aging, as well as effectively rebuilding the gut microbiota ecosystem.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Chemistry, Medicinal
Shiquan Chang, Xin Li, Yachun Zheng, Huimei Shi, Di Zhang, Bei Jing, Zhenni Chen, Guoqiang Qian, Guoping Zhao
Summary: This research demonstrates that kaempferol has anti-inflammatory and analgesic effects, potentially through modulating microglial polarization and inhibiting the TLR4/NF-kappa B signaling pathway.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ping Zhou, Jia Lai, Yueyue Li, Junzhu Deng, Chunling Zhao, Qianqian Huang, Fei Yang, Shuo Yang, Yuesong Wu, Xiaoqin Tang, Feihong Huang, Long Wang, Xinwu Huang, Wenjun Zou, Jianming Wu
Summary: This study investigated the effects of methyl gallate (MG) on ulcerative colitis (UC) and found that MG can regulate macrophage polarization, alleviate inflammation, and inhibit the TLR4/NF-kappa B signaling pathway in UC treatment. Additionally, MG can alter the diversity and composition of the gut microbiota, contributing to the therapeutic effects on UC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Yin-Yi Ding, Jinchi Lan, Yumeng Fang, Yuxiang Pan, Zhenyu Gu, Jing Xue, Ying Yang, Mengqi Jiang, Yujun Ge, Qing Shen
Summary: This study found that dityrosine exacerbates insulin resistance by reshaping gut microbiota composition and promoting the activation of the inflammatory pathway. This suggests that dityrosine poses a potential threat to human health.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Enhui Tang, Tong Hu, Zhaokang Jiang, Xiaojun Shen, Huan Lin, Haiyan Xian, Xinlan Wu
Summary: Isoquercitrin alleviates lipopolysaccharide-induced intestinal mucosal barrier damage in mice by inhibiting the TLR4/MyD88/NF-kappa B signaling pathway and modulating the intestinal flora.
Article
Chemistry, Medicinal
Zhi-Tong Zhang, Si-Min Deng, Chong Chen, Qing-Hui He, Xian-Wu Peng, Qing-Feng Liang, Guo-Dong Zhuang, Shu-Mei Wang, Dan Tang
Summary: This study found that pterostilbene can improve cognitive dysfunction in diabetic mice by inhibiting the TLR4/NF-kappa B signaling pathway through the microbiota-gut-brain axis. This may be one of the potential mechanisms for its neuroprotective effects.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shengzi Jin, Tongxu Guan, Shuang Wang, Mengxin Hu, Xingyao Liu, Siqi Huang, Yun Liu
Summary: Dioscin effectively attenuates cisplatin-induced mucositis by modulating the gut microflora profile, maintaining ileum integrity, and inhibiting the inflammatory response through the TLR4-MyD88-NF-kappa B pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Yongli Zhang, Yanni Xu, Ling Zhang, Yijun Chen, Tao Wu, Rui Liu, Wenjie Sui, Qiaomei Zhu, Min Zhang
Summary: Licorice extract improves blood glucose levels and metabolic functions in type 2 diabetic mice by regulating the gut microbiota and colon signaling pathway.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Microbiology
JingWen Cao, MiaoYu Chen, Ran Xu, MengYao Guo
Summary: This study investigated the mechanism of berberine in the treatment of inflammatory bowel disease (IBD) in cats. The results showed that berberine can alleviate inflammation by modulating the Toll-like receptors 4 (TLR4)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) signaling pathway and activating autophagy. Additionally, berberine significantly reduces the expression of inflammatory cytokines in cats' serum and enhances the antioxidant effect, thereby repairing intestinal barrier function.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhuang-peng Chang, Gui-feng Deng, Yun-yun Shao, Ding Xu, Yi-nan Zhao, Yi-fan Sun, Shi-quan Zhang, Rui-gang Hou, Jun-jin Liu
Summary: The study demonstrated that Shaoyao-Gancao Decoction treatment could effectively improve various aspects of PCOS in rats, such as reducing body weight, regulating hormone levels, and ameliorating ovarian pathology. Additionally, it was found that the treatment decreased the release of pro-inflammatory cytokines, enhanced tight junction protein expression, prevented LPS translocation, and reshaped the gut microbiota in PCOS rats. Moreover, the decoction also suppressed key genes and proteins related to the TLR4/NF-kappa B signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Hui Xia, Xiangling Shi, Beijia Zhou, Jing Sui, Chao Yang, Hechun Liu, Ligang Yang, Shaokang Wang, Guiju Sun
Summary: This study demonstrated the potential of milled flaxseed in inhibiting type 1 diabetes by reducing inflammation through down-regulation of TLR4/NF-kappa B pathways and altering gut microbiota.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Review
Biochemistry & Molecular Biology
Caiyun Yu, Dong Wang, Zaibin Yang, Tian Wang
Summary: TLR4/NF-kappa B is a key inflammatory signaling pathway involved in intestinal inflammation. Polyphenol phytochemicals exert pharmacological effects by targeting the TLR4/NF-kappa B signaling pathway, showing alleviative effects on intestinal inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Huajie Zhao, Min Li, Liang Liu, Duan Li, Linjing Zhao, Zhen Wu, Mingxu Zhou, Le Jia, Fan Yang
Summary: In this study, it was found that AEPSa, a purified fraction from Cordyceps militaris polysaccharides, could improve the gut microbiota of T2DM mice induced by high-fat diet and streptozotocin. AEPSa reduced the activation of the colonic Toll-like receptor 4/nuclear factor kappa-B pathway, upregulated intestinal tight junction protein expression, and improved glucose and serum lipid metabolism, hormone secretion, and complications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Food Science & Technology
Dan Li, Feijun Luo, Tianyi Guo, Shuai Han, Hanqing Wang, Qinlu Lin
Summary: Inflammation is a major factor affecting human health, and NF-kappa B plays a crucial role in its development. Lignans, important constituents of natural plants, are proven to have anti-inflammatory activities. This review systematically summarizes the types, structures, and sources of lignans, as well as their influence on mitigating inflammation. Lignans target NF-kappa B with various mechanisms to inhibit inflammatory cytokine expressions in the inflammatory response.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)