ERK inhibition in glioblastoma is associated with autophagy activation and tumorigenesis suppression

Autophagy Modulators in Cancer Therapy

(2021) Kamila Buzun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Friend or Foe: Paradoxical Roles of Autophagy in Gliomagenesis

(2021) Don Carlo Ramos Batara et al.   Cells

ERK/MAPK signalling pathway and tumorigenesis (Review)

(2020) Yan‑Jun Guo et al.   Experimental and Therapeutic Medicine

Author Correction: Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

(2020) Kirsten L. Bryant et al.   NATURE MEDICINE

Activation of dopamine receptor D1 inhibits glioblastoma tumorigenicity by regulating autophagic activity

(2020) Kang Yang et al.   CELLULAR ONCOLOGY

The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy

(2020) Jimin Yuan et al.   Journal of Hematology & Oncology

Modulating autophagy as a therapeutic strategy for the treatment of paediatric high‐grade glioma

(2019) Alison Howarth et al.   BRAIN PATHOLOGY

Correction to: Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells

(2019) Xihong Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PTPN1 promotes the progression of glioma by activating the MAPK/ERK and PI3K/AKT pathways and is associated with poor patient survival

(2019) Tao Jin et al.   ONCOLOGY REPORTS

Mouse embryonic palatal mesenchymal cells maintain stemness through the PTEN-Akt-mTOR autophagic pathway

(2019) Lungang Shi et al.   Stem Cell Research & Therapy

Glioblastoma: State of the Art and Future Perspectives

(2019) Tabatabai et al.   Cancers

Ampelopsin inhibits human glioma through inducing apoptosis and autophagy dependent on ROS generation and JNK pathway

(2019) Zhigang Guo et al.   BIOMEDICINE & PHARMACOTHERAPY

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012–2016

(2019) Quinn T Ostrom et al.   NEURO-ONCOLOGY

Autophagy in Human Health and Disease: Novel Therapeutic Opportunities

(2018) Francesca Giampieri et al.   ANTIOXIDANTS & REDOX SIGNALING

EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition

(2018) Barry Jutten et al.   Autophagy

Over-Expressed FEZF1 Predicts a Poor Prognosis in Glioma and Promotes Glioma Cell Malignant Biological Properties by Regulating Akt-ERK Pathway

(2018) Mingjun Yu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Marinobufagenin inhibits glioma growth through sodium pump α 1 subunit and ERK signaling-mediated mitochondrial apoptotic pathway

(2018) Yu-Long Lan et al.   Cancer Medicine

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

(2018) Álvaro F. Fernández et al.   NATURE

World Health Organization 2016 Classification of Central Nervous System Tumors

(2018) Phedias Diamandis et al.   NEUROLOGIC CLINICS

Downregulation of RNF138 inhibits cellular proliferation, migration, invasion and EMT in glioma cells via suppression of the Erk signaling pathway

(2018) Haibin Wu et al.   ONCOLOGY REPORTS

Autophagic and Apoptotic Pathways as Targets for Chemotherapy in Glioblastoma

(2018) Cristina Trejo-Solís et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Carnosic acid potentiates the anticancer effect of temozolomide by inducing apoptosis and autophagy in glioma

(2018) Naiyuan Shao et al.   JOURNAL OF NEURO-ONCOLOGY

Advances in epigenetic glioblastoma therapy

(2017) Dong Hoon Lee et al.   Oncotarget

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells

(2016) Sonam Dolma et al.   CANCER CELL

ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells

(2015) Jing-Hong Chen et al.   Autophagy

Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergoline

(2015) Shao Jian Lin et al.   Oncotarget

Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo

(2015) Zhiyun Yu et al.   Oncotarget

MAPK8IP1/JIP1 regulates the trafficking of autophagosomes in neurons

(2014) Meng-meng Fu et al.   Autophagy

Emerging treatment strategies for glioblastoma multiforme

(2014) S. K. Carlsson et al.   EMBO Molecular Medicine

Standards of care and novel approaches in the management of glioblastoma multiforme

(2014) Andreas F. Hottinger et al.   Chinese Journal of Cancer

SignaLink 2 – a signaling pathway resource with multi-layered regulatory networks

(2013) Dávid Fazekas et al.   BMC Systems Biology

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Discovery of a Novel ERK Inhibitor with Activity in Models of Acquired Resistance to BRAF and MEK Inhibitors

(2013) E. J. Morris et al.   Cancer Discovery

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Protein kinase B/Akt1 inhibits autophagy by down-regulating UVRAG expression

(2012) Wonseok Yang et al.   EXPERIMENTAL CELL RESEARCH

The acquisition of resistance to TNFα in breast cancer cells is associated with constitutive activation of autophagy as revealed by a transcriptome analysis using a custom microarray

(2011) Etienne Moussay et al.   Autophagy

Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice

(2011) J. F. de Groot et al.   NEURO-ONCOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Gene ontology analysis for RNA-seq: accounting for selection bias

(2010) Matthew D Young et al.   GENOME BIOLOGY

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy via Regulating Beclin 1

(2009) Jianrong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA

(2008) Shuh-hei Fujishiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extracellular Signal-Regulated Kinase 2 (ERK2) Phosphorylation Sites and Docking Domain on the Nuclear Pore Complex Protein Tpr Cooperatively Regulate ERK2-Tpr Interaction

(2008) T. Vomastek et al.   MOLECULAR AND CELLULAR BIOLOGY

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL