The comparison of microbial communities in thyroid tissues from thyroid carcinoma patients

Thyroid carcinoma is a common endocrine organ cancer associated with abnormal hormone secretion, leading to the disorder of metabolism. The intestinal microbiota is vital to maintain digestive and immunologic homeostasis. The relevant information of the microbial community in the gut and thyroid, including composition, structure, and relationship, is unclear in thyroid carcinoma patients. A total of 93 samples from 25 patients were included in this study. The results showed that microbial communities existed in thyroid tissue; gut and thyroid had high abundance of facultative anaerobes from the Proteobacteria phyla. The microbial metabolism from the thyroid and gut may be affected by the thyroid carcinoma cells. The cooccurrence network showed that the margins of different thyroid tissues were unique areas with more competition; the stabilization of microcommunities from tissue and stool may be maintained by several clusters of species that may execute different vital metabolism processes dominantly that are attributed to the microenvironment of cancer.

Automated summary

Thyroid carcinoma is associated with abnormal hormone secretion, leading to metabolic disorders. The study found microbial communities in thyroid tissue, with high abundance of facultative anaerobes from Proteobacteria phyla in the gut and thyroid. The microbial metabolism in the thyroid and gut may be affected by thyroid carcinoma cells.