Review
Endocrinology & Metabolism
Wen Jiang, Ganghua Lu, Dingwei Gao, Zhongwei Lv, Dan Li
Summary: Emerging studies have provided initial understanding of the thyroid-gut axis, but more research is needed to elucidate the specific relationships and mechanisms between gut microbiota and thyroid.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Camilla Virili, Ilaria Stramazzo, Marco Centanni
Summary: The intestinal microbiota has a pleiotropic effect on the intestinal barrier, nutrients metabolism, and immune system development and functions. Recent evidence suggests a possible role of altered gut microbiota composition in the pathogenesis and progression of several autoimmune disorders, including thyroid autoimmune diseases.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Boshen Gong, Chuyuan Wang, Fanrui Meng, Haoyu Wang, Bo Song, Yang Yang, Zhongyan Shan
Summary: Autoimmune thyroid disease (AITD) is characterized by thyroid dysfunction and deficits in the autoimmune system. Recent studies have shown altered gut microbiota composition in patients with AITD, with changes in alpha diversity and abundance of specific gut microbiota. The meta-analysis indicated an association between AITD and alteration of microbiota composition at the family, genus, and species levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nadia Sawicka-Gutaj, Dawid Gruszczynski, Natalia Zawalna, Kacper Nijakowski, Ilaria Muller, Tomasz Karpinski, Mario Salvi, Marek Ruchala
Summary: This systematic review revealed significant alterations in the diversity and composition of intestinal microbiota in both GD and HT patients, with HT patients showing higher diversity indices and GD patients showing lower values. Thyroid peroxidase antibodies showed significant correlations between bacterial levels and thyroid functional parameters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Dania Akeil Abed Alkader, Naweedullah Asadi, Uzma Solangi, Ransherjit Singh, Sayed Farhad Rasuli, Muhammad Jawad Farooq, F. N. U. Raheela, Radeyah Waseem, Syed Mujahid Gilani, Kiran Abbas, Moiz Ahmed, Desmond Boakye Tanoh, Hussain Haider Shah, Ayusha Dulal, Muhammad Sheheryar Hussain, Abdul Subhan Talpur
Summary: There is a significant difference in the diversity and composition of the gut microbiota in patients with autoimmune thyroid diseases (AITDs).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Hafiz Muhammad Ishaq, Imran Shair Mohammad, Riaz Hussain, Rashida Parveen, Jafir Hussain Shirazi, Yang Fan, Muhammad Shahzad, Khezar Hayat, Huan Li, Ayesha Ihsan, Kiran Sher Muhammad, Muhammad Usman, Siruo Zhang, Lu Yuan, Shakir Ullah, Ana Claudia Paiva-Santos, Jiru Xu
Summary: This study investigated the changes in gut bacterial composition in thyroid cancer patients and found significant dysbiosis in the gut microbiota of euthyroid thyroid cancer patients. The results suggest that this study may propose new approaches to understanding the disease pathways, mechanisms, and treatment of thyroid cancer patients.
Article
Microbiology
Hong Zhao, Lijie Yuan, Dongli Zhu, Banghao Sun, Juan Du, Jingyuan Wang
Summary: This study explored the role of gut microbiota in Graves' disease (GD) and Hashimoto's thyroiditis (HT). It found significant differences in the overall structure of gut microbiota between the GD and HT groups and the healthy control group. Certain bacterial species were associated with GD and HT. Functional analysis revealed that the ABC transporter metabolic pathway may be involved in the pathogenesis of GD and HT.
POLISH JOURNAL OF MICROBIOLOGY
(2022)
Article
Microbiology
Jilai Liu, Xuejun Qin, Boxi Lin, Jing Cui, Juan Liao, Fu Zhang, Qing Lin
Summary: This study found differences in gut microbiota composition between patients with Hashimoto's thyroiditis (HT) and healthy individuals, with gender being an important factor. Hormones, age, and TSH also play important roles in the development of HT.
Review
Oncology
Bolei Li, Tao Gong, Yu Hao, Xuedong Zhou, Lei Cheng
Summary: The gut microbiota plays a crucial role in cancer immunotherapy, affecting responses to the treatment. Modulating the gut microbiota has become a promising strategy for improving cancer immunotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Agata Czarnywojtek, Ewa Florek, Krzysztof Pietronczyk, Nadia Sawicka-Gutaj, Marek Ruchala, Ohad Ronen, Iain J. Nixon, Ashok R. Shaha, Juan Pablo Rodrigo, Ralph Patrick Tufano, Mark Zafereo, Gregory William Randolph, Alfio Ferlito
Summary: Vitamin D deficiency has received significant attention in medical research due to its role in regulating calcium-phosphorus metabolism and its potential impact on the immune system. Studies have shown that Vitamin D deficiency can affect autoimmune diseases, coeliac disease, infections, and cancer. Recent research has also highlighted its significant role in autoimmune thyroid diseases such as Hashimoto thyroiditis, Graves' disease, and postpartum thyroiditis. This review summarizes the current state of knowledge on the role of Vitamin D in autoimmune thyroid diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Mustafa Genco Erdem, Ozge Unlu, Fatma Ates, Denizhan Karis, Mehmet Demirci
Summary: The study found that the oral microbiota of male patients with treated and untreated hyperthyroidism differ, while the treatment method has no impact on the oral microbiota. By conducting extensive multicenter studies to identify the core oral microbiota and long-term monitoring of hyperthyroidism, important data for understanding the pathogenesis of the disease may be obtained.
Article
Immunology
Chenxu Zhao, Yang Yu, Jumei Liu, Guizhi Lu, Ting Li, Ying Gao, Junqing Zhang, Xiaohui Guo
Summary: The study found higher MAC deposition in thyroid tissues of HT and PTC patients, while no significant difference was observed in GD patients. At the serum level, Bb, C4d, C3a, and sC5b-9 levels were significantly increased in HT, GD, and PTC patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Cheuk Wun Li, Roman Osman, Francesca Menconi, Hanxi Hou, Clyde Schechter, Aizhan Kozhakhmetova, Yaron Tomer
Summary: This study designed two retro-inverso D-amino acid peptides, RT-15 and VT-15, to block the binding of thyroglobulin peptides to HLA-DR beta 1-Arg74, reducing T cell activation and providing new strategies for the treatment of AITD.
Review
Biochemistry & Molecular Biology
Leilei Ma, Li Zhang, Jing Li, Xiaotian Zhang, Yiran Xie, Xiaochen Li, Bo Yang, Hongtao Yang
Summary: Diabetic kidney disease (DKD) is closely related to imbalances of the gut microbiota, abnormal generation of microbial metabolites, and biological alterations of mitochondria. Recent studies have shown a strong correlation between the gut microbiome and mitochondrial function in the occurrence and development of DKD, with the gut microbiome's metabolites playing a vital role in this communication. However, the specific relationship between the gut microbiome, mitochondrial function, and DKD development remains unclear.
MOLECULAR MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Henrik M. Roager, Catherine Stanton, Lindsay J. Hall
Summary: The development of the infant gut microbiome is crucial for the microbiome ecology, function, and host health. Technological advancements now allow for better profiling of metabolites in the infant gut, providing insights into the roles of microbial-derived metabolites in shaping the microbiome community and influencing host-microbial interactions during early life. This review summarizes the current knowledge on the development of the infant gut microbiota and metabolism within the first year of life, emphasizing the importance of microbial metabolites in enhancing our understanding of early life interactions.
Article
Biotechnology & Applied Microbiology
Qi Liu, Yuji Li, Ming Dong, Fanmin Kong, Qi Dong
BIOMED RESEARCH INTERNATIONAL
(2017)
Review
Oncology
Qi Liu, Fanmin Kong, Jianping Zhou, Ming Dong, Qi Dong
CANCER MANAGEMENT AND RESEARCH
(2018)
Review
Oncology
Haixin Zhang, Qi Liu
TRANSLATIONAL ONCOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Hao Xu, Qi Liu
ONCOTARGETS AND THERAPY
(2020)
Review
Pharmacology & Pharmacy
Qi Liu, Wei Sun, Hao Zhang
Summary: This review summarizes the role and mechanisms of tumor-associated macrophages in thyroid cancer, as well as potential strategies for targeting tumor-associated macrophages in the treatment of thyroid cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Qi Liu, Bing Ma, Mingyuan Song, Wei Sun, Hao Zhang
Summary: The prognosis of papillary thyroid cancer (PTC) is better in women than in men, but this advantage diminishes with age and tumor growth. The interaction between sex and age plays a role in the prognosis of PTC, with women having better survival rates than men.
CLINICAL ENDOCRINOLOGY
(2023)