Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target

Therapeutic potential of coumestan Pks13 inhibitors for tuberculosis

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Identification of inhibitors targeting polyketide synthase 13 of Mycobacterium tuberculosis as antituberculosis drug leads

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A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm

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An overview of new antitubercular drugs, drug candidates, and their targets

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2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure–Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization

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Benzofuran derivatives and their anti-tubercular, anti-bacterial activities

(2018) Zhi Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis

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Antibacterial agents: New routes to tuberculosis treatment

(2017) Sarah Crunkhorn   NATURE REVIEWS DRUG DISCOVERY

Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis

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The Polyketide Synthase Pks13 Catalyzes a Novel Mechanism of Lipid Transfer in Mycobacteria

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Mycolic Acids: Structures, Biosynthesis, and Beyond

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New Approaches to Target the Mycolic Acid Biosynthesis Pathway for the Development of Tuberculosis Therapeutics

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Tuberculosis drug discovery in the post-post-genomic era

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Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents

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Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

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Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis

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Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

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The challenge of new drug discovery for tuberculosis

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Fast Standardized Therapeutic-Efficacy Assay for Drug Discovery against Tuberculosis

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Comparison of Human Ether-à-go-go Related Gene Screening Assays Based on IonWorks Quattro and Thallium Flux

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Overcoming Undesirable hERG Potency of Chemokine Receptor Antagonists Using Baseline Lipophilicity Relationships

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