Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties

Stepwise Insertion of Cobra Cardiotoxin CT2 into a Lipid Bilayer Occurs as an Interplay of Protein and Membrane “Dynamic Molecular Portraits”

(2021) Anastasia G. Konshina et al.   Journal of Chemical Information and Modeling

Dynamic “Molecular Portraits” of Biomembranes Drawn by Their Lateral Nanoscale Inhomogeneities

(2021) Roman G. Efremov   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Head-to-tail macrocyclization of albumin-binding domain fused interferon alpha improves the stability, activity, tumor penetration, and pharmacology

(2020) Jianwen Guo et al.   BIOMATERIALS

Antimicrobial peptides as therapeutic agents: opportunities and challenges

(2020) Margit Mahlapuu et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides

(2020) Ines Greco et al.   Scientific Reports

Molecular Dynamics Simulation of the Interaction of Two Linear Battacin Analogs with Model Gram-Positive and Gram-Negative Bacterial Cell Membranes

(2020) Aparajita Chakraborty et al.   ACS Omega

A gold mine for drug discovery: Strategies to develop cyclic peptides into therapies

(2019) Xiaoshu Jing et al.   MEDICINAL RESEARCH REVIEWS

Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions

(2019) Nigare Raheem et al.   Frontiers in Microbiology

The Mechanism by Which Luteolin Disrupts the Cytoplasmic Membrane of Methicillin-Resistant Staphylococcus aureus

(2018) Tao Zhang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Design, Synthesis, and Evaluation of Amphiphilic Cyclic and Linear Peptides Composed of Hydrophobic and Positively-Charged Amino Acids as Antibacterial Agents

(2018) Neda Riahifard et al.   MOLECULES

The Multifaceted Antibacterial Mechanisms of the Pioneering Peptide Antibiotics Tyrocidine and Gramicidin S

(2018) Michaela Wenzel et al.   mBio

An overview of antimicrobial peptides and the latest advances in their development

(2017) Josep M Sierra et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Cardiotoxins: Functional Role of Local Conformational Changes

(2017) Anastasia G. Konshina et al.   Journal of Chemical Information and Modeling

Potential of mean force for insertion of antimicrobial peptide melittin into a pore in mixed DOPC/DOPG lipid bilayer by molecular dynamics simulation

(2017) Yuan Lyu et al.   JOURNAL OF CHEMICAL PHYSICS

Antimicrobial Peptides Under Clinical Trials

(2016) Katarzyna E. Greber et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Antimicrobial Peptide Simulations and the Influence of Force Field on the Free Energy for Pore Formation in Lipid Bilayers

(2016) W. F. Drew Bennett et al.   Journal of Chemical Theory and Computation

Convergence of Staphylococcus aureus Persister and Biofilm Research: Can Biofilms Be Defined as Communities of Adherent Persister Cells?

(2016) Elaine M. Waters et al.   PLoS Pathogens

Antimicrobial Peptides: An Emerging Category of Therapeutic Agents

(2016) Margit Mahlapuu et al.   Frontiers in Cellular and Infection Microbiology

Helical cationic antimicrobial peptide length and its impact on membrane disruption

(2015) Melanie L. Juba et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Homeostasis, Inflammation, and Disease Susceptibility

(2015) Maya E. Kotas et al.   CELL

Antimicrobial Peptide Structure and Mechanism of Action: A Focus on the Role of Membrane Structure

(2015) Tzong-Hsien Lee et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide

(2015) Alberto Oddo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Amphipathic Membrane-Active Peptides Recognize and Stabilize Ruptured Membrane Pores: Exploring Cause and Effect with Coarse-Grained Simulations

(2015) Delin Sun et al.   LANGMUIR

Synthesis and antibacterial activity of trivalent ultrashort Arg-Trp-based antimicrobial peptides (AMPs)

(2015) Barbara C. Hoffknecht et al.   MedChemComm

Interaction of Daptomycin with Lipid Bilayers: A Lipid Extracting Effect

(2014) Yen-Fei Chen et al.   BIOCHEMISTRY

Antimicrobial potency and selectivity of simplified symmetric-end peptides

(2014) Na Dong et al.   BIOMATERIALS

Antibacterial evaluation of structurally amphipathic, membrane active small cationic peptidomimetics: Synthesized by incorporating 3-amino benzoic acid as peptidomimetic element

(2014) Sandeep Lohan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antibacterial Activities of Amphiphilic Cyclic Cell-Penetrating Peptides against Multidrug-Resistant Pathogens

(2014) Donghoon Oh et al.   MOLECULAR PHARMACEUTICS

Cyclization of the Antimicrobial Peptide Gomesin with Native Chemical Ligation: Influences on Stability and Bioactivity

(2013) Lai Yue Chan et al.   CHEMBIOCHEM

Community-associated MRSA: What makes them special?

(2013) Michael Otto   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

MRSA virulence and spread

(2012) Michael Otto   CELLULAR MICROBIOLOGY

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

Tuning the Activity of a Short Arg-Trp Antimicrobial Peptide by Lipidation of a C- or N-Terminal Lysine Side-Chain

(2012) H. Bauke Albada et al.   ACS Medicinal Chemistry Letters

Clinical effectiveness of rapid tests for methicillin resistant Staphylococcus aureus(MRSA) in hospitalized patients: a systematic review

(2011) Julie Polisena et al.   BMC INFECTIOUS DISEASES

Short native antimicrobial peptides and engineered ultrashort lipopeptides: similarities and differences in cell specificities and modes of action

(2011) Maria Luisa Mangoni et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Bacterial membrane lipids in the action of antimicrobial agents

(2010) Richard M. Epand et al.   JOURNAL OF PEPTIDE SCIENCE

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

PLATINUM: a web tool for analysis of hydrophobic/hydrophilic organization of biomolecular complexes

(2009) Timothy V. Pyrkov et al.   BIOINFORMATICS