Role of toll‐like receptors in modulation of cytokine storm signaling in SARS‐CoV‐2‐induced COVID‐19

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation

(2021) Mohamed M. Aboudounya et al.   MEDIATORS OF INFLAMMATION

TLR9 and COVID-19: A Multidisciplinary Theory of a Multifaceted Therapeutic Target

(2021) Gillina F. G. Bezemer et al.   Frontiers in Pharmacology

Increased TLR/MyD88 signaling in patients with obesity: is there a link to COVID-19 disease severity?

(2021) Ada M. Cuevas et al.   INTERNATIONAL JOURNAL OF OBESITY

Biomarkers in COVID-19: An Up-To-Date Review

(2021) Madhusudan Samprathi et al.   Frontiers in Pediatrics

SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs

(2021) Md Zobaer Hasan et al.   Scientific Reports

Distinct Patterns of Blood Cytokines Beyond a Cytokine Storm Predict Mortality in COVID-19

(2021) Christian Herr et al.   Journal of Inflammation Research

Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis

(2020) Anwar Santoso et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Diabetes and COVID-19: evidence, current status and unanswered research questions

(2020) Ritesh Gupta et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms

(2020) Gregorio Tersalvi et al.   JOURNAL OF CARDIAC FAILURE

Clinical characteristics of severe acute respiratory syndrome coronavirus 2 reactivation

(2020) Guangming Ye et al.   JOURNAL OF INFECTION

In silico studies on the comparative characterization of the interactions of SARS‐CoV‐2 spike glycoprotein with ACE‐2 receptor homologs and human TLRs

(2020) Abhigyan Choudhury et al.   JOURNAL OF MEDICAL VIROLOGY

ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome

(2020) Christian A. Devaux et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

The case of Complement activation in COVID-19 multiorgan impact

(2020) Marina Noris et al.   KIDNEY INTERNATIONAL

The current understanding and potential therapeutic options to combat COVID-19

(2020) Venkatesh Pooladanda et al.   LIFE SCIENCES

Bioinformatic analysis and identification of single-stranded RNA sequences recognized by TLR7/8 in the SARS-CoV-2, SARS-CoV, and MERS-CoV genomes

(2020) Mario Adán Moreno-Eutimio et al.   MICROBES AND INFECTION

Why the immune system fails to mount an adaptive immune response to a COVID‐19 infection

(2020) Pedram Ahmadpoor et al.   TRANSPLANT INTERNATIONAL

On the Alert for Cytokine Storm: Immunopathology in COVID ‐19

(2020) Lauren A. Henderson et al.   Arthritis & Rheumatology

Single-cell RNA Expression Profiling of ACE2, The Receptor of SARS-CoV-2

(2020) Yu Zhao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting Cytokine Storm to Manage Patients with COVID-19: A Mini-Review

(2020) Neda Roshanravan et al.   ARCHIVES OF MEDICAL RESEARCH

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease

(2020) Dennis McGonagle et al.   AUTOIMMUNITY REVIEWS

The cytokine storm and COVID‐19

(2020) Biying Hu et al.   JOURNAL OF MEDICAL VIROLOGY

Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment

(2020) Virna Margarita Martín Giménez et al.   LIFE SCIENCES

The role of biomarkers in diagnosis of COVID-19 – A systematic review

(2020) Muhammed Kermali et al.   LIFE SCIENCES

Laboratory biomarkers associated with COVID-19 severity and management

(2020) S. Keddie et al.   CLINICAL IMMUNOLOGY

The immune system and COVID-19: Friend or foe?

(2020) Fereshteh Yazdanpanah et al.   LIFE SCIENCES

Cytokine Storm in COVID-19 Patients, Its Impact on Organs and Potential Treatment by QTY Code-Designed Detergent-Free Chemokine Receptors

(2020) Mujahed I. Mustafa et al.   MEDIATORS OF INFLAMMATION

Is the presence of lung injury in COVID-19 an independent risk factor for secondary lung cancer?

(2020) Shao-Lin Tao et al.   MEDICAL HYPOTHESES

Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach

(2020) Chandra Bhushan Mishra et al.   BRIEFINGS IN BIOINFORMATICS

Discovery of M5049: A Novel Selective TLR7/8 Inhibitor for Treatment of Autoimmunity

(2020) Jaromir Vlach et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Autophagy during viral infection — a double-edged sword

(2018) Younho Choi et al.   NATURE REVIEWS MICROBIOLOGY

Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update

(2017) Hua Su et al.   Frontiers in Immunology

Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection

(2015) Allison L. Totura et al.   mBio

Caspases as the Key Effectors of Inflammatory Responses Against Bacterial Infection

(2014) Ryosuke Uchiyama et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Pattern recognition receptors and the inflammasome in kidney disease

(2014) Jaklien C. Leemans et al.   Nature Reviews Nephrology

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY