Loss of hepatocyte identity following aberrant YAP activation: A key mechanism in alcoholic hepatitis

Epithelial splicing regulatory protein 2–mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis

(2020) Jeongeun Hyun et al.   JOURNAL OF CLINICAL INVESTIGATION

Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver

(2020) Vanessa Dubois et al.   Molecular Systems Biology

Dysregulated activation of fetal liver programme in acute liver failure

(2019) Jeongeun Hyun et al.   GUT

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

(2019) Lara Planas-Paz et al.   Cell Stem Cell

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

(2019) Josepmaria Argemi et al.   Nature Communications

Meta-Analysis of Human and Mouse Biliary Epithelial Cell Gene Profiles

(2019) Verhulst et al.   Cells

Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo—a Meta-analysis of Individual Data

(2018) Alexandre Louvet et al.   GASTROENTEROLOGY

Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

(2018) Iván M. Moya et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis

(2017) Sachin H. Patel et al.   GASTROENTEROLOGY

A single-cell transcriptomic analysis reveals precise pathways and regulatory mechanisms underlying hepatoblast differentiation

(2017) Li Yang et al.   HEPATOLOGY

Alcoholic hepatitis: Translational approaches to develop targeted therapies

(2016) Pranoti Mandrekar et al.   HEPATOLOGY

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

(2016) Fuqin Fan et al.   Science Translational Medicine

Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis

(2015) Laurent Dubuquoy et al.   GUT

Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer

(2015) Dean Yimlamai et al.   JOURNAL OF HEPATOLOGY

Alcoholic liver disease: mechanisms of injury and targeted treatment

(2015) Alexandre Louvet et al.   Nature Reviews Gastroenterology & Hepatology

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression

(2015) Julien Fitamant et al.   Cell Reports

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

YAP activation is an early event and a potential therapeutic target in liver cancer development

(2014) Andrea Perra et al.   JOURNAL OF HEPATOLOGY

Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis

(2012) Pau Sancho-Bru et al.   HEPATOLOGY

Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice

(2011) Alexandre Louvet et al.   HEPATOLOGY

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

Alcoholic Hepatitis

(2009) Michael R. Lucey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preliminary evaluation of a self-complementary AAV2/8 vector for hepatic gene transfer of human apoE3 to inhibit atherosclerotic lesion development in apoE-deficient mice

(2008) Eyman Osman et al.   ATHEROSCLEROSIS

The Emerging Role of the Hippo Pathway in Cell Contact Inhibition, Organ Size Control, and Cancer Development in Mammals

(2008) Qi Zeng et al.   CANCER CELL