Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling

Selonsertib for Patients with Bridging Fibrosis or Compensated Cirrhosis Due to NASH: Results from Randomized Ph III STELLAR Trials

(2020) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Targeting FGF21 for the Treatment of Nonalcoholic Steatohepatitis

(2020) Mohammad Zarei et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Combination therapy for non-alcoholic steatohepatitis: rationale, opportunities and challenges

(2020) Jean-François Dufour et al.   GUT

Nonalcoholic Steatohepatitis

(2020) Adam C. Sheka et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

High fat diet significantly changed the global gene expression profile involved in hepatic drug metabolism and pharmacokinetic system in mice

(2020) Yuqi He et al.   Nutrition & Metabolism

Hepatocyte TRAF6 Aggravates Hepatic Inflammation and Fibrosis by Promoting Lys6- Linked Polyubiquitination of ASK1

(2019) Yutao Wang et al.   HEPATOLOGY

The redox‐active site of thioredoxin is directly involved in apoptosis signal‐regulating kinase 1 binding that is modulated by oxidative stress

(2019) Katarina Psenakova et al.   FEBS Journal

The Natural History of Nonalcoholic Fatty Liver Disease—An Evolving View

(2018) Christina C. Lindenmeyer et al.   Clinics in Liver Disease

Systematic review with meta-analysis: risk of hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis compared to other liver diseases

(2018) Jonathan G. Stine et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals

(2018) Marcos C. Carreira et al.   Oxidative Medicine and Cellular Longevity

The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial

(2017) Rohit Loomba et al.   HEPATOLOGY

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis

(2017) Peng Zhang et al.   NATURE MEDICINE

Mitogen-Activated Protein Kinase Regulation in Hepatic Metabolism

(2017) Ahmed Lawan et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Impact of high-fat diet on liver genes expression profiles in mice model of nonalcoholic fatty liver disease

(2016) Chunhua Wang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Tumor necrosis factor receptor-associated factor 5 (Traf5) acts as an essential negative regulator of hepatic steatosis

(2016) Ling Gao et al.   JOURNAL OF HEPATOLOGY

Targeting hepatic TRAF1-ASK1 signaling to improve inflammation, insulin resistance, and hepatic steatosis

(2016) Mei Xiang et al.   JOURNAL OF HEPATOLOGY

Deep sequencing of transcriptome profiling of GSTM2 knock-down in swine testis cells

(2016) Yuqi Lv et al.   Scientific Reports

Next generation sequencing of sex-specific genes in the livers of obese ZSF1 rats

(2015) Andrea Babelova et al.   GENOMICS

Metabolic make-up of NASH: from fat and sugar to amino acids

(2014) Silvia Sookoian et al.   Nature Reviews Gastroenterology & Hepatology

Glutathione S-transferase Mu 2-transduced mesenchymal stem cells ameliorated anti-glomerular basement membrane antibody-induced glomerulonephritis by inhibiting oxidation and inflammation

(2014) Yajuan Li et al.   Stem Cell Research & Therapy

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

(2012) Christopher K. Glass et al.   Cell Metabolism

Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients

(2012) Pierre Bedossa et al.   HEPATOLOGY

Glutathione S-transferase class mu regulation of apoptosis signal-regulating kinase 1 protein during VCD-induced ovotoxicity in neonatal rat ovaries

(2012) Poulomi Bhattacharya et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Regulatory functions of glutathioneS-transferase P1-1 unrelated to detoxification

(2011) Kenneth D. Tew et al.   DRUG METABOLISM REVIEWS

Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines

(2011) Andrea Sau et al.   Molecular BioSystems

Wnt/β-Catenin Signaling Activates and Determines Hepatic Zonal Expression of Glutathione S-Transferases in Mouse Liver

(2010) Stefanie Giera et al.   TOXICOLOGICAL SCIENCES