Identification of disease- and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis

Migraine and neuroinflammation: the inflammasome perspective

(2021) Oguzhan Kursun et al.   JOURNAL OF HEADACHE AND PAIN

A genetic interaction of NRXN2 with GABRE, SYT1 and CASK in migraine patients: a case-control study

(2021) Miguel Alves-Ferreira et al.   JOURNAL OF HEADACHE AND PAIN

Exogenous spermine attenuates myocardial fibrosis in diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress and the canonical Wnt signaling pathway

(2020) Jing Hu et al.   CELL BIOLOGY INTERNATIONAL

Participation of CXCL1 in the glial cells during neuropathic pain

(2020) Thamyris Reis Moraes et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads

(2019) Yang Liao et al.   NUCLEIC ACIDS RESEARCH

Spermine and gene methylation: a mechanism of lifespan extension induced by polyamine-rich diet

(2019) Kuniyasu Soda   AMINO ACIDS

Comparing migraine with and without aura to healthy controls using RNA sequencing

(2019) Lisette JA Kogelman et al.   CEPHALALGIA

Calcitonin Gene‐Related Peptide Modulators – The History and Renaissance of a New Migraine Drug Class

(2019) Richard Hargreaves et al.   HEADACHE

Advances in genetics of migraine

(2019) Heidi G. Sutherland et al.   JOURNAL OF HEADACHE AND PAIN

Spinal blockage of CXCL1 and its receptor CXCR2 inhibits paclitaxel-induced peripheral neuropathy in mice

(2019) Marianne N. Manjavachi et al.   NEUROPHARMACOLOGY

Spermine oxidase: A Promising Therapeutic Target for Neurodegeneration in Diabetic Retinopathy

(2019) S. Priya Narayanan et al.   PHARMACOLOGICAL RESEARCH

Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury

(2019) Anna Piotrowska et al.   Frontiers in Immunology

Synovial Cytokines Significantly Correlate with Osteoarthritis-Related Knee Pain and Disability: Inflammatory Mediators of Potential Clinical Relevance

(2019) Timo A. Nees et al.   Journal of Clinical Medicine

Serum Levels of Mitochondrial and Microbial Metabolites Reflect Mitochondrial Dysfunction in Different Stages of Sepsis

(2019) Beloborodova et al.   Metabolites

Succinate in ischemia: Where does it come from?

(2019) Christos Chinopoulos   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Targeting calcitonin gene-related peptide: a new era in migraine therapy

(2019) Andrew Charles et al.   LANCET

The metabolic face of migraine — from pathophysiology to treatment

(2019) Elena C. Gross et al.   Nature Reviews Neurology

Mild Traumatic Brain Injury Causes Nociceptive Sensitization through Spinal Chemokine Upregulation

(2019) Peyman Sahbaie et al.   Scientific Reports

Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition

(2018)   CEPHALALGIA

Energy Metabolism Impairment in Migraine

(2018) Sabina Cevoli et al.   CURRENT MEDICINAL CHEMISTRY

Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota

(2018) Carolina Serena et al.   ISME Journal

Transcriptional Alterations in the Trigeminal Ganglia, Nucleus and Peripheral Blood Mononuclear Cells in a Rat Orofacial Pain Model

(2018) Timea Aczél et al.   Frontiers in Molecular Neuroscience

History and Review of anti-Calcitonin Gene-Related Peptide (CGRP) Therapies: From Translational Research to Treatment

(2018) Stewart J. Tepper   HEADACHE

Genetic regulation of longevity and age-associated diseases through the methionine sulfoxide reductase system

(2018) Derek B. Oien et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Progression in migraine: Role of mast cells and pro-inflammatory and anti-inflammatory cytokines

(2018) Pio Conti et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Migraine Attack as a Homeostatic, Neuroprotective Response to Brain Oxidative Stress: Preliminary Evidence for a Theory

(2017) Jonathan M. Borkum   HEADACHE

Epiregulin and EGFR interactions are involved in pain processing

(2017) Loren J. Martin et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma succinate is a predictor of mortality in critically injured patients

(2017) Angelo DʼAlessandro et al.   Journal of Trauma and Acute Care Surgery

The chemokine receptor CXCR2 supports nociceptive sensitization after traumatic brain injury

(2017) De-Yong Liang et al.   Molecular Pain

CXCL1/CXCR2 signaling in pathological pain: Role in peripheral and central sensitization

(2017) Rangel L. Silva et al.   NEUROBIOLOGY OF DISEASE

Pathophysiology of Migraine: A Disorder of Sensory Processing

(2017) Peter J. Goadsby et al.   PHYSIOLOGICAL REVIEWS

Plasma succinate is a predictor of mortality in critically injured patients

(2017) Angelo DʼAlessandro et al.   Journal of Trauma and Acute Care Surgery

Serum levels of adiponectin, CCL3/MIP-1α, and CCL5/RANTES discriminate migraine from tension-type headache patients

(2016) Renan B. Domingues et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Blood gene expression studies in migraine: Potential and caveats

(2016) Zachary Gerring et al.   CEPHALALGIA

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

(2016) Padhraig Gormley et al.   NATURE GENETICS

Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermineN1-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells

(2015) Swati Mandal et al.   BIOCHEMICAL JOURNAL

Involvement of astrocyte and oligodendrocyte gene sets in migraine

(2015) Else Eising et al.   CEPHALALGIA

A meta-analysis of biomarkers related to oxidative stress and nitric oxide pathway in migraine

(2015) Monica Neri et al.   CEPHALALGIA

Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis

(2015) Jonathan M. Borkum   HEADACHE

Protein modification and maintenance systems as biomarkers of ageing

(2015) Valerie Vanhooren et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Intracellular spermine prevents acid-induced uncoupling of Cx43 gap junction channels

(2015) Serguei N. Skatchkov et al.   NEUROREPORT

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

From migraine genes to mechanisms

(2015) Else A. Tolner et al.   PAIN

The function of spermine

(2014) Anthony E. Pegg   IUBMB LIFE

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Increased interictal serum levels of CXCL8/IL-8 and CCL3/MIP-1α in migraine

(2014) Halina Duarte et al.   NEUROLOGICAL SCIENCES

Epiregulin: Roles in normal physiology and cancer

(2014) David J. Riese et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

Pathview: an R/Bioconductor package for pathway-based data integration and visualization

(2013) Weijun Luo et al.   BIOINFORMATICS

Alterations in PACAP-38-like immunoreactivity in the plasma during ictal and interictal periods of migraine patients

(2013) Bernadett Tuka et al.   CEPHALALGIA

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Evaluation of serum transforming growth factor β1 and C-reactive protein levels in migraine patients

(2013) Işil Güzel et al.   Neurologia i Neurochirurgia Polska

Succinate: a metabolic signal in inflammation

(2013) Evanna Mills et al.   TRENDS IN CELL BIOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Genomic Expression Patterns in Menstrual-Related Migraine in Adolescents

(2012) Andrew Hershey et al.   HEADACHE

Genome-wide association analysis identifies susceptibility loci for migraine without aura

(2012) Tobias Freilinger et al.   NATURE GENETICS

Intracellular polyamines enhance astrocytic coupling

(2012) Jan Benedikt et al.   NEUROREPORT

Local action of the proinflammatory cytokines IL-1β and IL-6 on intracranial meningeal nociceptors

(2011) Xichun Zhang et al.   CEPHALALGIA

Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers

(2011) Faisal Mohammad Amin et al.   CEPHALALGIA

Significant differences in gene expression of GABA receptors in peripheral blood leukocytes of migraineurs

(2011) Prue N. Plummer et al.   GENE

Tumor necrosis factor-α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions

(2010) Xi-Chun Zhang et al.   PAIN

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Interictal Metabolic Changes in Episodic Migraine: A Voxel-Based FDG-PET Study

(2009) JH Kim et al.   CEPHALALGIA

Origin of pain in migraine: evidence for peripheral sensitisation

(2009) Jes Olesen et al.   LANCET NEUROLOGY

PACAP38 induces migraine-like attacks in patients with migraine without aura

(2008) Henrik Winther Schytz et al.   BRAIN

Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients

(2008) Shoji Yamane et al.   Journal of Inflammation-London

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE