Review
Biochemistry & Molecular Biology
Ryan Tsz-Hei Tse, Christine Yim-Ping Wong, Peter Ka-Fung Chiu, Chi-Fai Ng
Summary: This article summarizes the roles of spermine in cancer development and its application as a diagnostic, prognostic, and therapeutic tool in various types of cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Keiko Kashiwagi, Kazuei Igarashi
Summary: Acrolein, produced from spermine, is a major contributor to oxidative stress and has been found to be more toxic than reactive oxygen species. It can easily conjugate with proteins, causing changes in their nature. Glutathione is responsible for detoxifying acrolein in cells, and it is mainly produced from spermine. The molecular characteristics of acrolein toxicity and tissue damage have been investigated.
Article
Biochemistry & Molecular Biology
Mirja Harms, Pascal von Maltitz, Ruediger Gross, Benjamin Mayer, Miriam Deniz, Janis Mueller, Jan Muench
Summary: The high cytotoxic activity of semen hampers studies of human semen in cell or tissue culture. The damaging activity of semen is caused by amine oxidases, which convert abundant polyamines in seminal plasma into toxic intermediates. The presence of fetal calf serum increases the cytotoxicity of seminal plasma and polyamines to immortalized cells, primary blood mononuclear cells, and vaginal tissue. Caution should be taken when investigating the effects of polyamines and seminal plasma on cellular functions due to their confounding cytotoxic effects. The addition of the amine oxidase inhibitor aminoguanidine to fetal calf serum and/or the utilization of serum-free medium can greatly reduce this cytotoxicity and should be implemented in future studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hidenori Sanayama, Kiyonori Ito, Susumu Ookawara, Takeshi Uemura, Sojiro Imai, Satoshi Kiryu, Miho Iguchi, Yoshio Sakiyama, Hitoshi Sugawara, Yoshiyuki Morishita, Kaoru Tabei, Kazuei Igarashi, Kuniyasu Soda
Summary: Multiple mechanisms regulate polyamine concentration and blood polyamines can be excreted in urine. Accumulation of polyamines in renal dysfunction has been observed, with increased blood polyamine concentrations in patients with renal failure. Hemodialysis (HD) may compensate for polyamine excretion, but little is known about polyamine excretion. In this study, blood polyamine levels were measured in HD patients, and the relationship between polyamine concentrations and health-related indicators was examined. The results suggest that whole blood SPM/SPD in hemodialysis patients may serve as a new indicator of prognosis and health status.
Review
Biochemistry & Molecular Biology
Qiang Peng, Christine Yim-Ping Wong, Isabella Wai-yin Cheuk, Jeremy Yuen-Chun Teoh, Peter Ka-Fung Chiu, Chi-Fai Ng
Summary: Decreased levels of spermine in prostate cancer compared to benign tissue may serve as an indicator of malignant transformation, with potential applications in therapy and chemoprevention. Ongoing research suggests a complex relationship between spermine metabolism and prostate cancer pathophysiology, offering new opportunities for diagnostic and therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Jianhui Bai, Ke Jin, Wei Qin, Yuqing Wang, Qiang Yin
Summary: Alkali stress can result in yellow leaves due to the down-regulation of specific proteins in oat plants, while up-regulation of certain proteins can enhance alkali tolerance. Moreover, adding exogenous spermine can improve alkali tolerance in oat plants, leading to increased chlorophyll contents and plant dry weights.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Mijin Jung, Xiaobei Pan, Emma L. Cunningham, Anthony P. Passmore, Bernadette McGuinness, Daniel F. McAuley, David Beverland, Seamus O'Brien, Tim Mawhinney, Jonathan M. Schott, Henrik Zetterberg, Brian D. Green
Summary: The mechanisms underlying postoperative delirium development are unclear. Measurement of plasma metabolites may improve understanding of its causes. This study found widespread changes in plasma metabolite levels following surgery, with ornithine and spermine being the only metabolites significantly differing between control and delirium samples. However, these two metabolites were not significantly associated with an increased risk of delirium.
Article
Biochemistry & Molecular Biology
Rasoul Eslami-Farsani, Sadegh Farhadian, Behzad Shareghi
Summary: This study evaluates the impact of spermine on myoglobin and finds that the binding between spermine and myoglobin is spontaneous, leading to the quenching of myoglobin's fluorescence through a static process. Additionally, the presence of spermine increases the thermal stability of myoglobin and induces changes in its secondary structure.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Cell Biology
Hong-Xiang Shi, Chao Liang, Chao-Yan Yao, Zi-Xuan Gao, Jia Qin, Jin-Lan Cao, Ming-Zhu Zhang, Ying-Ying Li, Meng-Qing Wang, Hua Sun, Song-Qiang Xie, Dong Fang
Summary: This study reveals the immunosuppressive role of spermine in hepatocellular carcinoma by activating the CaSR pathway to promote the expression of PD-L1 and reducing the infiltration of CD8(+) T cells. This discovery highlights the crucial function of spermine in establishing immune privilege.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Multidisciplinary Sciences
Silviya Ruseva, Inna Popova, Valentin Lozanov, Vanio Mitev
Summary: The study examined levels of Met, Hcy, and polyamines in psoriasis patients, finding correlations between them. Significant increases in Met and polyamine concentrations were observed in psoriatic plaques. The results highlight the importance of a balanced protein diet and intake of vitamins B-12 and B-9 in psoriasis treatment.
Article
Biochemistry & Molecular Biology
Sachie Nakatani, Yasuhiro Horimoto, Natsumi Nakabayashi, Mayumi Karasawa, Masahiro Wada, Kenji Kobata
Summary: This study found that exogenously supplemented spermine can inhibit adipocyte differentiation, thereby preventing obesity. Through in vitro and in vivo experiments, it was discovered that spermine can significantly reduce lipid accumulation and delay cell differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Soumyadeep Sarkar, Sudip Gorai, Akhilesh Potnis, Padma Nilaya Jonnalgadda, Soumyaditya Mula, Goutam Chakraborty
Summary: This study presents a novel approach for fluorescence-based spermine sensing using a synthesized BODIPY dye and an inexpensive anionic surfactant SDS. It achieves low detection limits and offers advantages like low interference and photodamage in biological samples. It shows potential for real-world applications.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Mariana Barros, Alejandro Lopez-Carrasco, Pedro Amoros, Salvador Gil, Pablo Gavina, Margarita Parra, Jamal El Haskouri, Maria Carmen Terencio, Ana M. Costero
Summary: A new hybrid organic-inorganic material consisting of functionalized MCM-41 particles loaded with Rhodamine 6G has been developed for sensing spermine and spermidine. The double layer of organic matter within the porous material enables detection of the target compounds while remaining silent in the presence of other biologically important amines. The sensor shows detection limits of 27 μM and 45 μM for spermine and spermidine, respectively, and is capable of detecting these compounds in aqueous solutions and cells.
Article
Chemistry, Analytical
Zorica S. Stojanovic, Ana D. Durovic, Snezana Z. Kravic, Amir M. Ashrafi, Lukas Richtera
Summary: A simple electroanalytical procedure using the ZnONPs-MWCNTs-CPE sensor has been developed to determine polyamine spermine. The sensor showed a linear response from 2 mu mol L-1 to 100 mu mol L-1 in borate buffer pH 8.5, with a detection limit of 0.300 mu mol L-1 and quantification limit of 0.998 mu mol L-1. The sensor demonstrated high reproducibility, stability, robustness, and no interference effects of inorganic ions and organic molecules. The method also achieved satisfactory recovery results (98.41-101.34 %) for the determination of spermine in human urine samples, indicating promising opportunities for practical clinical analysis.
Article
Polymer Science
Na Yeon Kwon, Youngseo Kim, Meenal Kataria, Su Hong Park, Seunguk Cho, Amit Kumar Harit, Han Young Woo, Min Ju Cho, Sungnam Park, Dong Hoon Choi
Summary: In this study, three novel aromatic imide-based conjugated donor-sigma-acceptor (D-sigma-A) dyad-based polymers were synthesized and their photophysical and electrochemical characteristics were studied. Among them, BDTBT-PDI showed efficient extraction and portable detection abilities for Fe2+ ions, as well as ultrasensitive detection of spermine in urine samples and fermented food samples. The on-off fluorescence behavior of BDTBT-PDI enabled the development of molecular logic gates.
