Brain single-nucleus transcriptomics highlights that polystyrene nanoplastics potentially induce Parkinson’s Disease-like neurodegeneration by causing energy metabolism disorders in mice
出版年份 2022 全文链接
标题
Brain single-nucleus transcriptomics highlights that polystyrene nanoplastics potentially induce Parkinson’s Disease-like neurodegeneration by causing energy metabolism disorders in mice
作者
关键词
Nanoplastics, Single-nucleus transcriptomics, Parkinson’s disease, Neurodegeneration, Energy metabolism disorder
出版物
JOURNAL OF HAZARDOUS MATERIALS
Volume -, Issue -, Pages 128459
出版商
Elsevier BV
发表日期
2022-02-11
DOI
10.1016/j.jhazmat.2022.128459
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Effects of Nanoplastics and Butyl Methoxydibenzoylmethane on Early Zebrafish Embryos Identified by Single-Cell RNA Sequencing
- (2021) Yuxuan Liu et al. ENVIRONMENTAL SCIENCE & TECHNOLOGY
- Long-term nanoplastics exposure results in multi and trans-generational reproduction decline associated with germline toxicity and epigenetic regulation in Caenorhabditis elegans
- (2021) Chan-Wei Yu et al. JOURNAL OF HAZARDOUS MATERIALS
- Advanced imaging and labelling methods to decipher brain cell organization and function
- (2021) Daniel Choquet et al. NATURE REVIEWS NEUROSCIENCE
- Nanoplastics are neither microplastics nor engineered nanoparticles
- (2021) Julien Gigault et al. Nature Nanotechnology
- Placing nanoplastics in the context of global plastic pollution
- (2021) Denise M. Mitrano et al. Nature Nanotechnology
- You are what you eat: Microplastics in the feces of young men living in Beijing
- (2021) Na Zhang et al. SCIENCE OF THE TOTAL ENVIRONMENT
- A Critical Review on the Impacts of Nanoplastics and Microplastics on Aquatic and Terrestrial Photosynthetic Organisms
- (2021) Camille Larue et al. Small
- Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction
- (2021) Gabriele G. Schiattarella et al. Nature Communications
- Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
- (2021) Mor R. Alkaslasi et al. Nature Communications
- Polystyrene microplastics induce apoptosis via ROS-mediated p53 signaling pathway in zebrafish
- (2021) Sathisaran Umamaheswari et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Response of tyramine and glutamate related signals to nanoplastic exposure in Caenorhabditis elegans
- (2021) Shuting Wang et al. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
- Size-dependent adverse effects of microplastics on intestinal microbiota and metabolic homeostasis in the marine medaka (Oryzias melastigma)
- (2021) Xu Zhang et al. ENVIRONMENT INTERNATIONAL
- Presence of airborne microplastics in human lung tissue
- (2021) Luís Fernando Amato-Lourenço et al. JOURNAL OF HAZARDOUS MATERIALS
- Underestimated health risks: polystyrene micro- and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis
- (2021) Boxuan Liang et al. Particle and Fibre Toxicology
- The global threat from plastic pollution
- (2021) Matthew MacLeod et al. SCIENCE
- Cellular internalization and release of polystyrene microplastics and nanoplastics
- (2021) Ling Liu et al. SCIENCE OF THE TOTAL ENVIRONMENT
- Chronic exposure to UV-aged microplastics induces neurotoxicity by affecting dopamine, glutamate, and serotonin neurotransmission in Caenorhabditis elegans
- (2021) Haibo Chen et al. JOURNAL OF HAZARDOUS MATERIALS
- Dietary polystyrene nanoplastics exposure alters liver lipid metabolism and muscle nutritional quality in carnivorous marine fish large yellow croaker (Larimichthys crocea)
- (2021) Wencong Lai et al. JOURNAL OF HAZARDOUS MATERIALS
- Single-Cell RNA Sequencing Reveals Size-Dependent Effects of Polystyrene Microplastics on Immune and Secretory Cell Populations from Zebrafish Intestines
- (2020) Weiqing Gu et al. ENVIRONMENTAL SCIENCE & TECHNOLOGY
- Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease
- (2020) Yingyue Zhou et al. NATURE MEDICINE
- Astrocytes and Microglia: In Sickness and in Health
- (2020) Ilia D. Vainchtein et al. TRENDS IN NEUROSCIENCES
- A critical review of extraction and identification methods of microplastics in wastewater and drinking water
- (2020) Dounia Elkhatib et al. ENVIRONMENTAL SCIENCE & TECHNOLOGY
- Key role of MIF-related neuroinflammation in neurodegeneration and cognitive impairment in Alzheimer’s disease
- (2020) Elham Nasiri et al. MOLECULAR MEDICINE
- A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors
- (2020) Michal Slyper et al. NATURE MEDICINE
- Gene therapy for overexpressing Neuregulin 1 type I in skeletal muscles promotes functional improvement in the SOD1G93A ALS mice
- (2020) Guillem Mòdol-Caballero et al. NEUROBIOLOGY OF DISEASE
- Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention
- (2020) Plamena R. Angelova et al. MEDICINAL RESEARCH REVIEWS
- The plastic brain: neurotoxicity of micro- and nanoplastics
- (2020) Minne Prüst et al. Particle and Fibre Toxicology
- Cytotoxic effects of polystyrene nanoplastics with different surface functionalization on human HepG2 cells
- (2020) Yixin He et al. SCIENCE OF THE TOTAL ENVIRONMENT
- Uptake, accumulation and associated cellular alterations of environmental samples of microplastics in the seaworm Hediste diversicolor
- (2020) Omayma Missawi et al. JOURNAL OF HAZARDOUS MATERIALS
- Estimation of the mass of microplastics ingested – A pivotal first step towards human health risk assessment
- (2020) Kala Senathirajah et al. JOURNAL OF HAZARDOUS MATERIALS
- In vivo effects on the immune function of fathead minnow (Pimephales promelas) following ingestion and intraperitoneal injection of polystyrene nanoplastics
- (2020) Armando Elizalde-Velázquez et al. SCIENCE OF THE TOTAL ENVIRONMENT
- Gas6 Inhibits Toll-Like Receptor-Mediated Inflammatory Pathways in Mouse Microglia via Axl and Mer
- (2020) Shannon E. Gilchrist et al. Frontiers in Cellular Neuroscience
- Plasticenta: First evidence of microplastics in human placenta
- (2020) Antonio Ragusa et al. ENVIRONMENT INTERNATIONAL
- Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy
- (2020) Ana Belen Malpartida et al. TRENDS IN BIOCHEMICAL SCIENCES
- Mitochondria, OxPhos, and neurodegeneration: cells are not just running out of gas
- (2019) Estela Area-Gomez et al. JOURNAL OF CLINICAL INVESTIGATION
- Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
- (2019) Dvir Aran et al. NATURE IMMUNOLOGY
- Exposure to Microplastics (
- (2019) P. Zuccarello et al. WATER RESEARCH
- Size-dependent effects of polystyrene microplastics on cytotoxicity and efflux pump inhibition in human Caco-2 cells
- (2019) Bing Wu et al. CHEMOSPHERE
- Review of micro- and nanoplastic contamination in the food chain
- (2019) Brigitte Toussaint et al. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment
- Comprehensive Integration of Single-Cell Data
- (2019) Tim Stuart et al. CELL
- Time-dependent effects of polystyrene nanoparticles in brine shrimp Artemia franciscana at physiological, biochemical and molecular levels
- (2019) Inmaculada Varó et al. SCIENCE OF THE TOTAL ENVIRONMENT
- Detection of Various Microplastics in Human Stool
- (2019) Philipp Schwabl et al. ANNALS OF INTERNAL MEDICINE
- TAM Receptor Pathways at the Crossroads of Neuroinflammation and Neurodegeneration
- (2019) Giacomo Tondo et al. DISEASE MARKERS
- Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases
- (2019) Rong Cai et al. JOURNAL OF CLINICAL INVESTIGATION
- The art of using t-SNE for single-cell transcriptomics
- (2019) Dmitry Kobak et al. Nature Communications
- Behavior and biochemical responses of the polychaeta Hediste diversicolor to polystyrene nanoplastics
- (2019) M.S.S. Silva et al. SCIENCE OF THE TOTAL ENVIRONMENT
- Organoid and Assembloid Technologies for Investigating Cellular Crosstalk in Human Brain Development and Disease
- (2019) Rebecca M. Marton et al. TRENDS IN CELL BIOLOGY
- PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5
- (2018) Dae-Hee Lee et al. Autophagy
- Polystyrene microplastics induce microbiota dysbiosis and inflammation in the gut of adult zebrafish
- (2018) Yuanxiang Jin et al. ENVIRONMENTAL POLLUTION
- Accumulation, tissue distribution, and biochemical effects of polystyrene microplastics in the freshwater fish red tilapia ( Oreochromis niloticus )
- (2018) Jiannan Ding et al. ENVIRONMENTAL POLLUTION
- Neuregulin-1 elicits a regulatory immune response following traumatic spinal cord injury
- (2018) Arsalan Alizadeh et al. Journal of Neuroinflammation
- Plastic contamination of the food chain: A threat to human health?
- (2018) R.H. Waring et al. MATURITAS
- Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease
- (2018) Seung Pil Yun et al. NATURE MEDICINE
- Molecular Architecture of the Mouse Nervous System
- (2018) Amit Zeisel et al. CELL
- Parkinson's disease: convergence on synaptic homeostasis
- (2018) Sandra‐Fausia Soukup et al. EMBO JOURNAL
- Glia as architects of central nervous system formation and function
- (2018) Nicola J. Allen et al. SCIENCE
- Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice
- (2018) Yuanxiang Jin et al. SCIENCE OF THE TOTAL ENVIRONMENT
- Autophagy in the presynaptic compartment in health and disease
- (2017) Vinoy Vijayan et al. JOURNAL OF CELL BIOLOGY
- Oligodendroglia: metabolic supporters of neurons
- (2017) Thomas Philips et al. JOURNAL OF CLINICAL INVESTIGATION
- The Potential Liver, Brain, and Embryo Toxicity of Titanium Dioxide Nanoparticles on Mice
- (2017) Xiaochuan Jia et al. Nanoscale Research Letters
- Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
- (2017) Dung T. Le et al. SCIENCE
- Quantitative investigation of the mechanisms of microplastics and nanoplastics toward zebrafish larvae locomotor activity
- (2017) Qiqing Chen et al. SCIENCE OF THE TOTAL ENVIRONMENT
- Wear and Tear of Tyres: A Stealthy Source of Microplastics in the Environment
- (2017) Pieter Jan Kole et al. International Journal of Environmental Research and Public Health
- The Potential Liver, Brain, and Embryo Toxicity of Titanium Dioxide Nanoparticles on Mice
- (2017) Xiaochuan Jia et al. Nanoscale Research Letters
- Parkinson disease
- (2017) Werner Poewe et al. Nature Reviews Disease Primers
- Production, use, and fate of all plastics ever made
- (2017) Roland Geyer et al. Science Advances
- Uptake and Accumulation of Polystyrene Microplastics in Zebrafish (Danio rerio) and Toxic Effects in Liver
- (2016) Yifeng Lu et al. ENVIRONMENTAL SCIENCE & TECHNOLOGY
- Are iron oxide nanoparticles safe? Current knowledge and future perspectives
- (2016) Vanessa Valdiglesias et al. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
- Lithium suppression of tau induces brain iron accumulation and neurodegeneration
- (2016) P Lei et al. MOLECULAR PSYCHIATRY
- Pericytes of the neurovascular unit: key functions and signaling pathways
- (2016) Melanie D Sweeney et al. NATURE NEUROSCIENCE
- Microplastic exposure studies should be environmentally realistic
- (2016) Robin Lenz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Potential Health Impact of Environmentally Released Micro- and Nanoplastics in the Human Food Production Chain: Experiences from Nanotoxicology
- (2015) Hans Bouwmeester et al. ENVIRONMENTAL SCIENCE & TECHNOLOGY
- Uptake and bio-reactivity of polystyrene nanoparticles is affected by surface modifications, ageing and LPS adsorption: in vitro studies on neural tissue cells
- (2015) Kumarasamy Murali et al. Nanoscale
- Spatial reconstruction of single-cell gene expression data
- (2015) Rahul Satija et al. NATURE BIOTECHNOLOGY
- Differential bioreactivity of neutral, cationic and anionic polystyrene nanoparticles with cells from the human alveolar compartment: robust response of alveolar type 1 epithelial cells
- (2015) Pakatip Ruenraroengsak et al. Particle and Fibre Toxicology
- Translocation of differently sized and charged polystyrene nanoparticles in in vitro intestinal cell models of increasing complexity
- (2014) Agata P. Walczak et al. Nanotoxicology
- GSVA: gene set variation analysis for microarray and RNA-Seq data
- (2013) Sonja Hänzelmann et al. BMC BIOINFORMATICS
- VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration
- (2013) Peter Carmeliet et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Policy: Classify plastic waste as hazardous
- (2013) Chelsea M. Rochman et al. NATURE
- Protein degradation pathways in Parkinson’s disease: curse or blessing
- (2012) Darius Ebrahimi-Fakhari et al. ACTA NEUROPATHOLOGICA
- A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles
- (2012) Lisa Hoelting et al. ARCHIVES OF TOXICOLOGY
- Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation
- (2012) Davis J. McCarthy et al. NUCLEIC ACIDS RESEARCH
- clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
- (2012) Guangchuang Yu et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers
- (2011) E. Sierra-Filardi et al. BLOOD
- Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
- (2011) Berislav V. Zlokovic NATURE REVIEWS NEUROSCIENCE
- A scaling normalization method for differential expression analysis of RNA-seq data
- (2010) Mark D Robinson et al. GENOME BIOLOGY
- Oxidation of potassium channels by ROS: a general mechanism of aging and neurodegeneration?
- (2009) Federico Sesti et al. TRENDS IN CELL BIOLOGY
- Molecular dissection of reactive astrogliosis and glial scar formation
- (2009) Michael V. Sofroniew TRENDS IN NEUROSCIENCES
- Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2D3receptor activation
- (2008) Arianna Bellucci et al. JOURNAL OF NEUROCHEMISTRY
- Fast unfolding of communities in large networks
- (2008) Vincent D Blondel et al. JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT
- Mitochondria in Neuroplasticity and Neurological Disorders
- (2008) Mark P. Mattson et al. NEURON
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started