Article
Oncology
Arturo Simoni-Nieves, Soraya Salas-Silva, Lisette Chavez-Rodriguez, Alejandro Escobedo-Calvario, Matthis Desoteux, Leticia Bucio, Veronica Souza, Roxana U. Miranda-Labra, Linda E. Munoz-Espinosa, Cedric Coulouarn, Maria Concepcion Gutierrez-Ruiz, Jens U. Marquardt, Luis E. Gomez-Quiroz
Summary: The study provides evidence that cholesterol is related to the development and aggressiveness of hepatocellular carcinoma, especially in western countries where high cholesterol diets are common. Cholesterol and high-fat diets are major causes of non-alcoholic fatty liver disease and NASH progression, which may also contribute to the development of HCC.
Review
Biochemistry & Molecular Biology
Roberta Forlano, Mathuri Sivakumar, Benjamin H. Mullish, Pinelopi Manousou
Summary: NAFLD is an increasingly common liver disease globally, with no approved pharmaceutical treatment available. Manipulating the intestinal microbiome may be a potential therapeutic option for patients with NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Julien Tap, Stine Storsrud, Boris Le Neve, Aurelie Cotillard, Nicolas Pons, Joel Dore, Lena Ohman, Hans Tornblom, Muriel Derrien, Magnus Simren
Summary: Individuals with severe IBS were found to have a higher intake of poorer-quality food items, and the covariations between gut microbiota at subspecies level and diet were associated with factors such as symptom severity. The study provides insight into diet-microbiota-symptom interactions and may guide future interventional studies on gut microbiome-based nutritional recommendations for managing gastrointestinal symptoms.
Article
Gastroenterology & Hepatology
Barbara Olendzki, Vanni Bucci, Caitlin Cawley, Rene Maserati, Margaret McManus, Effie Olednzki, Camilla Madziar, David Chiang, Doyle Ward, Randall Pellish, Christine Foley, Shakti Bhattarai, Beth A. McCormick, Ana Maldonado-Contreras
Summary: This study aims to investigate the impact of specific foods on the intestinal microbiome in patients with IBD and explore the interactions between diet and immunity to provide personalized nutrition guidance for IBD patients with dysbiosis-related conditions.
Article
Endocrinology & Metabolism
Dong D. Wang, Qibin Qi, Zheng Wang, Mykhaylo Usyk, Daniela Sotres-Alvarez, Josiemer Mattei, Martha Tamez, Marc D. Gellman, Martha Daviglus, Frank B. Hu, Meir J. Stampfer, Curtis Huttenhower, Rob Knight, Robert D. Burk, Robert C. Kaplan
Summary: This study reveals that adherence to the Mediterranean diet can affect gut microbiome composition and functions. The association between the Mediterranean diet and diabetes prevalence varies depending on individual gut microbial composition.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Brian K. Trevelline, Kevin D. Kohl
Summary: This study demonstrates that the gut microbiome can influence host diet selection behavior by mediating the availability of essential amino acids, revealing a mechanism by which gut microbiota can regulate host foraging behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, General & Internal
Claudia Cantoni, Qingqi Lin, Yair Dorsett, Laura Ghezzi, Zhongmao Liu, Yeming Pan, Kun Chen, Yanhui Han, Zhengze Li, Hang Xiao, Matthew Gormley, Yue Liu, Suresh Bokoliya, Hunter Panier, Cassandra Suther, Emily Evans, Li Deng, Alberto Locca, Robert Mikesell, Kathleen Obert, Pamela Newland, Yufeng Wu, Amber Salter, Anne H. Cross, Phillip Tarr, Amy Lovett-Racke, Laura Piccio, Yanjiao Zhou
Summary: This study conducted a six-month longitudinal multi-omics study on multiple sclerosis (MS) patients and healthy controls, revealing multi-system alterations in gut microbiota, immune system, and blood metabolome. The study demonstrated the interactions between gut microbiome and host immune system, metabolism, and diet, and identified microbiome and metabolome features related to the degree of disability in MS patients. Furthermore, a correlation network linking meat intake with gut microbiota and blood metabolites was discovered.
Article
Ecology
Siddiq Akbar, Xianxian Li, Zihao Ding, Qi Liu, Jing Huang, Qiming Zhou, Lei Gu, Zhou Yang
Summary: The study demonstrates that the microbiome of Daphnia is flexible and varies with genotype, diet, and medium-associated microbes. Not all bacteria are beneficial to Daphnia, and only symbionts can increase Daphnia performance.
Review
Gastroenterology & Hepatology
Gertrude Ecklu-Mensah, Jack Gilbert, Suzanne Devkota
Summary: Diet plays a crucial role in shaping the gut microbiota, with dietary selection pressures throughout life influencing the composition and diversity of microorganisms. Personalized dietary solutions should be tailored to an individual's personal history and nutritional needs.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sonja Lang, Anna Martin, Xinlian Zhang, Fedja Farowski, Hilmar Wisplinghoff, Maria J. G. T. Vehreschild, Marcin Krawczyk, Angela Nowag, Anne Kretzschmar, Claus Scholz, Philipp Kasper, Christoph Roderburg, Raphael Mohr, Frank Lammert, Frank Tacke, Bernd Schnabl, Tobias Goeser, Hans-Michael Steffen, Muenevver Demir
Summary: The study found that BMI was most strongly associated with histological fibrosis in NAFLD patients, while PNPLA3 gene variants, gut bacterial features, and dietary factors were all associated with different histology features.
LIVER INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Pajau Vangay, Tonya Ward, Sarah Lucas, Lalit K. Beura, Dominique Sabas, Max Abramson, Lisa Till, Susan L. Hoops, Purna Kashyap, Ryan C. Hunter, David Masopust, Dan Knights
Summary: In this study, the differential effects of human gut microbiota from the United States and rural Thailand on the murine gut mucosa and immune system were assessed. The results suggest that Western-associated human gut microbes contribute to a pro-inflammatory immune response.
Article
Nutrition & Dietetics
Kirra Borrello, Unhee Lim, Song-Yi Park, Kristine R. Monroe, Gertraud Maskarinec, Carol J. Boushey, Lynne R. Wilkens, Timothy W. Randolph, Loic Le Marchand, Meredith A. Hullar, Johanna W. Lampe
Summary: This study found that racial/ethnic differences in GM composition may be influenced by differences in diet. Overall diet quality and intake of certain foods were found to have significant effects on GM composition, which may contribute to racial/ethnic health disparities.
Article
Behavioral Sciences
Mary Seeman
Summary: The review examines the potential role of intestinal organisms in response/non-response to antipsychotics, highlighting that current research in this area is mostly theoretical but showing increasing evidence from animal experiments and clinical trials on the impact of gut bacteria on drug response.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Immunology
Sonakshi Rastogi, Sneha Mohanty, Sapna Sharma, Prabhanshu Tripathi
Summary: This review summarizes the recent progress in understanding the effects of dietary metabolites, particularly short-chain fatty acids (SCFAs), on the gut-lung axis and its impact on lung health. The role of the gut-lung axis in SARS-CoV-2 mediated inflammation is also highlighted. By analyzing global research progress and knowledge gaps, the study predicts future research directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Eleanor M. Townsend, Lucy Kelly, George Muscatt, Joshua D. Box, Nicole Hargraves, Daniel Lilley, Eleanor Jameson
Summary: The investigation of the human microbiome has revolutionized our understanding of the impact of microorganisms on human development and health. While most research has focused on bacteria and fungi, the exploration of gut viruses is still in its early stages. Bacteriophages, which influence bacterial populations in various ecosystems, remain relatively understudied in the context of the human gut microbiome.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Xiang Zhang, Lina Fan, Jianfeng Wu, Hongzhi Xu, Wing Yan Leung, Kaili Fu, Jingtong Wu, Ken Liu, Kwan Man, Xiaoyong Yang, Jiahuai Han, Jianlin Ren, Jun Yu
JOURNAL OF HEPATOLOGY
(2019)
Article
Cell Biology
Xiaoting Chen, Hung Chan, Lin Zhang, Xiaodong Liu, Idy H. T. Ho, Xiang Zhang, Jeffery Ho, Wei Hu, Yuanyuan Tian, Shanglong Kou, Chee Sam Chan, Jun Yu, Sunny H. Wong, Tony Gin, Matthew T. V. Chan, Xuegang Sun, William K. K. Wu
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Oncology
Tong Li, Beifang Li, Asgharpour Sara, Christine Ay, Wing Yan Leung, Yanquan Zhang, Yujuan Dong, Qiaoyi Liang, Xiang Zhang, Philip Weidner, Tobias Gutting, Hans-Michael Behrens, Christoph Roecken, Joseph J. Y. Sung, Matthias P. Ebert, Jun Yu, Elke Burgermeister
Article
Medicine, General & Internal
Jing Zhang, Jun-Zhe Huang, Yan-Quan Zhang, Xiang Zhang, Liu-Yang Zhao, Chuan-Gen Li, Yun-Fei Zhou, Hong Wei, Jun Yu
Article
Microbiology
Zhangran Chen, Yurou Xie, Fei Zhou, Bangzhou Zhang, Jingtong Wu, Luxi Yang, Shuangbin Xu, Robert Stedtfeld, Qiongyun Chen, Jingjing Liu, Xiang Zhang, Hongzhi Xu, Jianlin Ren
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Gastroenterology & Hepatology
Xiang Zhang, Olabisi Oluwabukola Coker, Eagle Sh Chu, Kaili Fu, Harry C. H. Lau, Yi-Xiang Wang, Anthony W. H. Chan, Hong Wei, Xiaoyong Yang, Joseph J. Y. Sung, Jun Yu
Summary: High dietary cholesterol leads to sequential progression of steatosis, steatohepatitis, fibrosis and eventually HCC in mice, concomitant with insulin resistance. Cholesterol-induced NAFLD-HCC formation is associated with gut microbiota dysbiosis, with specific bacterial composition changes between stages of liver disease. Alterations in gut bacterial metabolites were also observed with dietary cholesterol intake. Therapies targeting cholesterol and gut microbiota may be effective for preventing NAFLD-HCC.
Correction
Gastroenterology & Hepatology
Xiang Zhang, Lina Fan, Jianfeng Wu, Hongzhi Xu, Wing Yan Leung, Kaili Fu, Jingtong Wu, Ken Liu, Kwan Man, Xiaoyong Yang, Jiahuai Han, Jianlin Ren, Jun Yu
JOURNAL OF HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Weixin Liu, Xiang Zhang, Hongzhi Xu, Shengmian Li, Harry Cheuk-Hay Lau, Qiongyun Chen, Bin Zhang, Liuyang Zhao, Huarong Chen, Joseph Jao-Yiu Sung, Jun Yu
Summary: The study revealed that the microbial communities within colorectal neoplasia are heterogeneous, with variations in abundance of CRC-associated pathobionts playing a role in CRC development. Intra-neoplasia changes in microbial abundance were observed along the adenoma-carcinoma sequence. Furthermore, significant differences in intra-neoplasia microbiota were found between biopsies with and without genetic alterations, highlighting the association of intratumoral microbial heterogeneity with genetic changes.
Article
Gastroenterology & Hepatology
Jinkai Liu, Wei Geng, Hanyong Sun, Changan Liu, Fan Huang, Jie Cao, Lei Xia, Hongchuan Zhao, Jianning Zhai, Qing Li, Xiang Zhang, Ming Kuang, Shunli Shen, Qiang Xia, Vincent Wai-Sun Wong, Jun Yu
Summary: The study conducted integrative metabolomics analysis on the altered metabolites in HCC patients, revealing distinct clusters of metabolites in serum, liver tissue, and stool samples that differed significantly from healthy controls. Elevated and depleted metabolites identified in portal vein samples may play a role in HCC development. Linoleic acid and phenol were found to inhibit HCC proliferation, suggesting their potential as protective metabolites.
Review
Medicine, General & Internal
Juqiang Han, Xiang Zhang
Summary: NAFLD, including NASH, is a prevalent cause of chronic liver disease worldwide, with potential for severe outcomes like cirrhosis and hepatocellular carcinoma. The complement system, particularly the protein C3, has been identified as playing a crucial role in the pathogenesis of NAFLD, offering new insights for diagnosis and treatment.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Qian Song, Xiang Zhang
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease worldwide due to obesity and metabolic syndrome. Dysbiosis of the gut microbiome and metabolomic changes play a crucial role in the initiation and progression of NAFLD through the gut-liver axis.
Article
Gastroenterology & Hepatology
Chuangen Li, Yong Wang, Dabin Liu, Chi Chun Wong, Olabisi Oluwabukola Coker, Xiang Zhang, Changan Liu, Yunfei Zhou, Yali Liu, Wei Kang, Ka Fai To, Joseph J. Y. Sung, Jun Yu
Summary: This study reveals that SQLE plays an oncogenic role in colorectal cancer through both cell intrinsic effects and modulation of the gut microbiota-metabolite axis. SQLE can be a potential therapeutic target and prognostic marker for colorectal cancer.
Review
Biochemistry & Molecular Biology
Chuangen Li, Harry Cheuk-Hay Lau, Xiang Zhang, Jun Yu
Summary: This review explores the overall features and mechanisms of carcinogen-induced and transgenic mouse models for colon tumorigenesis, as well as their limitations and applications in evaluating and studying drugs and treatment regimens against CRC. These mouse models provide a better understanding of the mechanisms of colon tumorigenesis and facilitate the discovery of novel therapeutic strategies against CRC.
Meeting Abstract
Gastroenterology & Hepatology
Changsheng Yan, Xiang Zhang