Article
Chemistry, Applied
Zhilang Xu, Die Yang, Tao Long, Lun Yuan, Shi Qiu, Defu Li, Changdao Mu, Liming Ge
Summary: pH-responsive nanoparticles based on modified hydroxyethyl starch have been developed as an effective drug delivery system for cancer chemotherapy. These nanoparticles can accumulate in tumors and selectively release drugs in the acidic microenvironment, providing a sustained release of the drug.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Physical
Thejus Baby, Yun Liu, Guangze Yang, Dong Chen, Chun-Xia Zhao
Summary: A new microfluidic nanoprecipitation approach has been developed for making polymer NPs with tunable drug loading up to 50%. The synthesized NPs remain very stable under acidic conditions but release the drug in a sustained manner at neutral pH.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Nurul Huda Kamsani, Muhammad Salahuddin Haris, Manisha Pandey, Muhammad Taher, Kamal Rullah
Summary: Electrospinning technique is a versatile method for producing continuous nanofibers, which has become cost-effective and drawn keen interests in the biomedical field. Smart electrospun pH-responsive nanofibers have various applications in emerging biomedical developments such as cancer drug targeting, wound healing, and vaginal drug delivery.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Zhaosheng Hou, Jinwei Teng, Jinjian Wei, Tiantian Hao, Zhengqi Liu
Summary: A highly pH-sensitive biodegradable polyurethane, PEEU-Py, was successfully designed and synthesized for intelligent drug delivery applications. The polymer exhibited pH-sensitive drug release behavior and showed satisfactory cytocompatibility with cells.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Saman Emami Gerami, Mehrab Pourmadadi, Hooman Fatoorehchi, Fatemeh Yazdian, Hamid Rashedi, Mona Navaei Nigjeh
Summary: In this study, nanocomposites of hematite/chitosan/polyvinylpyrrolidone were synthesized as a drug carrier for doxorubicin, exhibiting pH-sensitive and controlled release properties. The chemical and physical interactions within the nanocomposites were confirmed through analyses, and they demonstrated good cytotoxicity and anticancer effects in cell experiments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Munir Ahmad Khan, Abul Kalam Azad, Muhammad Safdar, Asif Nawaz, Muhammad Akhlaq, Pijush Paul, Md. Kamal Hossain, Md. Habibur Rahman, Roua S. Baty, Attalla F. El-kott, Mohamed Kamel, Simona G. Bungau, Mohamed M. Abdel-Daim
Summary: This study aimed to synthesize and characterize pH-sensitive hydrogels loaded with 5-fluorouracil and investigate their controlled release properties. The formulations exhibited different swelling and release behaviors at different pH conditions, suggesting their potential as oral controlled colon drug delivery carriers.
Article
Biochemistry & Molecular Biology
Haibin Zhang, Zhiyang Gu, Wenya Li, Lili Guo, Litong Wang, Lan Guo, Saibo Ma, Baoqin Han, Jing Chang
Summary: Oral drug delivery is the most preferred mode of treatment due to its convenience and non-invasiveness. However, delivering protein drugs orally has been a challenge. This study developed a novel OCMC/SA nanohydrogel that solves this problem, with high drug loading capacity and passive drug targeting function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Marie Piantino, Masahiko Nakamoto, Michiya Matsusaki
Summary: Efficient and selective drug delivery systems (DDS) in cancer therapy remain a major challenge. A recent study introduced a molecular block (MB) therapy targeting the cancer cell microenvironment, which induced cancer cell death through self-aggregation and cell membrane disruption. The optimized MB showed increased sensitivity to the cancer microenvironment and avoided off-target accumulation in the bloodstream, making it a promising approach for improved cancer cell targeting.
Article
Engineering, Environmental
Shahla Karimzadeh, Siamak Javanbakht, Behzad Baradaran, Mohammad-Ali Shahbazi, Mahmoud Hashemzaei, Ahad Mokhtarzadeh, Helder A. Santos
Summary: Nanotechnology, particularly involving nanoscaled metal-organic frameworks, shows great potential in revolutionizing traditional nanocarriers in biomedicine due to their tunable structural features, high surface area, and biocompatibility. Specifically, stimuli-responsive NMOFs are efficient candidates for biomedical applications, offering the flexibility to respond to a variety of triggers, both internal and external. Recent advances in this field have focused on designing multifunctional smart NMOFs that can adapt to different stimuli, providing innovative solutions for future biomedical applications.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Physical
Feng-Qin Luo, Guojun Chen, Wei Xu, Daojia Zhou, Jia-Xian Li, Yong-Cong Huang, Run Lin, Zhen Gu, Jin-Zhi Du
Summary: The study presents a novel glucose-responsive insulin delivery system using pH-sensitive insulin-loaded nanoparticles and glucose oxidase-catalase-loaded pH-insensitive nanoparticles. This system effectively regulates blood glucose levels within normal ranges for a prolonged period and reduces inflammation risks towards normal skin.
Article
Engineering, Biomedical
Wenchao Huang, Longshuai Zhang, Jiawei Sun, Yuanzi Sun, Like Gong, Sisi Ge, Xunbin Wei, Weiping Gao
Summary: This study presents intelligent nanoworms with dual-acid-sensitive properties, which can penetrate and release drugs in tumor cells, effectively suppressing tumor growth with better efficacy compared to nanospheres and doxorubicin, and without observed side effects in a mouse model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Carolina Henriques Cavalcante, Renata Salgado Fernandes, Juliana de Oliveira Silva, Caroline Mari Ramos Oda, Elaine Amaral Leite, Geovanni Dantas Cassali, Ives Charlie-Silva, Bianca Helena Ventura Fernandes, Lucas Antonio Miranda Ferreira, Andre Luis Branco de Barros
Summary: The developed pH-sensitive micelles encapsulating DOX showed promising results with small diameter, high stability, low toxicity, and significantly better inhibition of tumor growth compared to other forms of DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Fulya Gulmez, Aysima Yercan, Banu Kocaaga, F. Seniha Guner
Summary: This study focused on synthesizing bio-based polyurethane films from renewable sources, investigating drug release behavior, swelling, and degradation. It was found that reducing the molecular weight of PEG enhanced drug release, with CO:PEG ratio and medium pH being critical factors. The drug release mechanisms were evaluated using various kinetic models.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Physical
Chaolei Hu, Yimeng Sun, Gil van Wissen, Yitong Peng, Andrij Pich
Summary: In this study, visible light- and temperature-responsive poly(N-vinylcaprolactam) microgels decorated by donor-acceptor Stenhouse adducts (DASAs) were synthesized for the first time using a robust and straightforward post-modification synthesis route. The microgels exhibited homogeneous distributions and temperature responsiveness in aqueous solutions. The photoswitching behaviors of the microgels in different solvents were systematically investigated, and their size in aqueous solutions could be modulated by visible light irradiation. Moreover, the microgels showed potential application in the photostimulated delivery of hydrophobic drugs.
CHEMISTRY OF MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Man Zhou, Lijuan Wen, Cui Wang, Qiao Lei, Yongxiu Li, Xiaoqing Yi
Summary: Paclitaxel is a chemotherapy drug used in tumor treatment, but its poor solubility limits its clinical applications. Smart drug delivery systems can improve the solubility, permeability, and stability of drugs, enhancing therapeutic efficacy and reducing side effects. Polymeric prodrugs have shown great advantages in drug delivery due to their high drug loading and stability. This study summarizes the development of stimulus-sensitive polymeric prodrug micelles based on paclitaxel, considering different types of stimuli such as pH, reduction, enzyme, and reactive oxygen species (ROS). The design, synthesis, and biomedical applications of stimulus-responsive polymeric prodrugs of paclitaxel are reviewed, and future directions in this field are discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mehrnaz Mehrabani, Mojdeh Esmaeili-Tarzi, Hamid Forootanfar, Mohammad Hadi Nematollahi, Ibrahim M. Banat, Mandana Ohadi, Gholamreza Dehghannoudeh
Summary: Lipopeptide biosurfactants (LPBs) were studied for their effect on human umbilical vein endothelial cells (HUVECs), showing no significant proliferative effect but an increase in migration and tube formation rates at a concentration of 300 μg/mL, along with enhanced expression of angiogenic factors.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Mohammad Amin Raeisi Estabragh, Marzieh Sajadi Bami, Mandana Ohadi, Ibrahim M. Banat, Gholamreza Dehghannoudeh
Summary: Peptides and proteins are essential in biological systems and the human body, but oral administration is often unsuitable for proteins. Therefore, alternative oral drug delivery systems that are suitable for peptides and proteins need to be explored.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2021)
Article
Chemistry, Inorganic & Nuclear
Soodeh Salarpour, Majid Rajaee, Ehsan Mohajeri, Maryam Hobab, Mandana Ohadi, Ibrahim M. Banat, Gholamreza Dehghannoudeh
Summary: The research found that the mixture of Tween 20 and glycerol has the lowest hemolytic activity, while the Tween 80-ethanol mixture has the highest hemolytic activity. Short-chain alcohols affect the self-aggregation of surfactant monomers, and increasing alcohol concentrations will increase the CMCs of nonionic surfactants.
JOURNAL OF CLUSTER SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Maryam Shamseddini Lori, Mandana Ohadi, Mohammad Amin Raeisi Estabragh, Sepehr Afsharipour, Ibrahim M. Banat, Gholamreza Dehghannoudeh
Summary: There are various proteins and enzymes in the human body, and their dysfunction can result in diseases. The oral administration of proteins faces challenges due to degradation in the gastrointestinal tract and limited permeability. Studies have shown that the use of pH-sensitive polymer-based carriers can enhance the bioavailability of orally administered proteins.
PROTEIN AND PEPTIDE LETTERS
(2021)
Article
Environmental Sciences
Marzieh Sajadi Bami, Mohammad Amin Raeisi Estabragh, Mandana Ohadi, Ibrahim M. Banat, Gholamreza Dehghannoudeh
Summary: Biosurfactants, as amphiphilic compounds, have shown good tolerance to environmental factors and play an important role in bioremediation. They can remove organic molecules through mechanisms such as surface tension reduction, emulsification, and micelle formation, as well as remove heavy metals by increasing contact with the surface of heavy metal deposits.
SOIL & SEDIMENT CONTAMINATION
(2022)
Article
Pharmacology & Pharmacy
H. Fathalipour-Rayeni, H. Forootanfar, P. Khazaeli, M. Mehrabani, H-R Rahimi, M. Shakibaie, E. Jafari, M. Doostmohammadi, M. S. Bami, M. Adeli-Sardou, P. M. Shaghooei, M. Ohadi
Summary: This study evaluated the antioxidant effect and wound healing activity of a topical formulation containing Heliotropium bacciferum Forssk extract. The results showed that the formulation exhibited good wound healing impact and notable antioxidant capacity.
ANNALES PHARMACEUTIQUES FRANCAISES
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Amin Raeisi Estabragh, Marzieh Sajadi Bami, Gholamreza Dehghannoudeh, Yasmin Dehghan Noudeh, Eskandar Moghimipour
Summary: Incorporating an emulsion onto a gel base creates emulgel, a drug delivery system that enhances stability and penetration, allowing it to envelop both hydrophilic and lipophilic molecules. Emulgel provides controlled drug release with improved patient compliance and therapeutic efficacy. The preparation involves three main stages: creating a water-in-oil or oil-in-water emulsion, providing the gel base, and incorporating the emulsion onto the gel base with continuous stirring. Various materials are used, including different oils, emulsifiers, and gelling agents. The physical properties, particle size distribution, spreadability, permeation, and drug release rate are evaluated during development and characterization. Emulgel has potential clinical uses for treating skin disorders and diseases such as chronic anal fissures, and has been studied for delivering anti-acne, analgesic, and anti-inflammatory drugs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Banafshe Abadi, Payam Khazaeli, Hamid Forootanfar, Mehdi Ranjbar, Meysam Ahmadi-Zeidabadi, Ali Nokhodchi, Atefeh Ameri, Mahboubeh Adeli-Sardou, Maryam Amirinejad
Summary: This study aimed to assess the antitumor effects of selenium nanoparticles functionalized with chitosan and sialic acid on human glioblastoma cell lines. Sialic acid successfully improved the stability and biological activity of the nanoparticles.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Toktam Salehi, Mohammad Amin Raeisi Estabragh, Soodeh Salarpour, Mandana Ohadi, Gholamreza Dehghannoudeh
Summary: Peptides and proteins play crucial roles in living organisms and their malfunction can lead to various diseases. The use of proteins in treating diseases like cancers and hepatitis is increasing. However, the large and hydrophilic structure of proteins and the presence of biological and lipophilic membranes pose limitations to protein administration. Increasing protein absorption through these membranes can be achieved by using absorption enhancers, such as surfactants, phospholipids, and cyclodextrins. This review focuses on other absorption enhancers and their mechanisms in protein administration routes.
JOURNAL OF DRUG TARGETING
(2023)
Article
Microbiology
Hakimeh Rakhshandeh, Mehrdad Shamsaddini Bafti, Behnaz Familsatarian, Maryam Nooshadokht, Payam Khazaeli, Omid Raiesi, Bagher Amirheidari
Summary: This study successfully immobilized Clostridium perfringens cells inside uniform alginate microspheres using cell immobilization technique, paving the way for further optimization and establishment of an efficient bacterial encapsulation method.
IRANIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Payam Khazaeli, Abbas Pardakhty, Amin Mehrabian, Marziyeh Sajadi Bami, Moslem Lari Najafi
Summary: This study evaluated the physicochemistry and formulation of propranolol niosomal gel for the treatment of infantile hemangioma. The results showed that the niosomal gel had good physical and chemical properties, and promising effects in controlling infantile hemangioma.
IRANIAN RED CRESCENT MEDICAL JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Mohammad Amin Raeisi Estabragh, Abbas Pardakhty, Saeid Ahmadzadeh, Shahriar Dabiri, Reza Malekpour Afshar, Mohammad Farajli Abbasi
Summary: This study demonstrates that niosomes can be used as effective drug delivery systems for alpha-lipoic acid (ALA) in the treatment of cerebral ischemia. Niosomes increase the bioavailability and penetration of ALA into the central nervous system, reducing complications associated with cerebral ischemia.
ADVANCED PHARMACEUTICAL BULLETIN
(2022)
Article
Pharmacology & Pharmacy
Xueliang Xiu, Shichao Ma, Zhiyong Li, Zhipeng Li, Xuemei Li, Yangtao Ruan, Dezhao Li, Jianwei Wang, Fengsen Ma
Summary: Liposomes are promising delivery vehicles for drugs and vaccines. The use of microfluidic chips for liposome preparation is an effective method. However, traditional liposome preparation technologies hinder their industrial production and clinical application. This study presents a novel three-dimensional integrated microfluidic device for continuous liposome preparation and purification, which shows potential for industrial production of nano-pharmaceutical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2024)