Synthesis, Characterization and Biological Activity of Novel Cu(II) Complexes of 6-Methyl-2-Oxo-1,2-Dihydroquinoline-3-Carbaldehyde-4n-Substituted Thiosemicarbazones

Computational Studies of 4-Formylpyridinethiosemicarbazone and Structural and Biological Studies of Its Ni(II) and Cu(II) Complexes

(2019) Mydhili P. Sripathi et al.   HETEROATOM CHEMISTRY

Mitochondria-localizing N-heterocyclic thiosemicarbazone copper complexes with good cytotoxicity and high antimetastatic activity

(2019) ShanShan Gu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Characterization, and in Vitro Anticancer Activity of Copper and Zinc Bis(Thiosemicarbazone) Complexes

(2019) Rukhsana Anjum et al.   INORGANIC CHEMISTRY

Biological evaluation of copper(II) complexes on N(4)−substituted thiosemicarbazide derivatives and diimine co-ligands using DNA interaction, antibacterial and in vitro cytotoxicity

(2019) Neelaveni Rajendran et al.   JOURNAL OF COORDINATION CHEMISTRY

Design, Synthesis, DNA/HSA Binding, and Cytotoxic Activity of Half-Sandwich Ru(II)-Arene Complexes Containing Triarylamine–Thiosemicarbazone Hybrids

(2019) Mathiyan Muralisankar et al.   ACS Omega

Novel 4-quinoline-thiosemicarbazone derivatives: Synthesis, antiproliferative activity, in vitro and in silico biomacromolecule interaction studies and topoisomerase inhibition

(2019) Amélia Galdino Ribeiro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization and bioactivities of a new covalent copper(II) compound derived from {P2Mo5O23}6− and thiosemicarbazones

(2019) Haiyan Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and structure of complexes (NiII, AgI) of substituted benzaldehyde thiosemicarbazones and antitubercular activity of NiII complex

(2019) Dharmender Sharma et al.   INORGANICA CHIMICA ACTA

Synthesis, and biological evaluation of complexes based on thiosemicarbazone ligand

(2019) T.A. Yousef et al.   JOURNAL OF MOLECULAR STRUCTURE

Comparison of metabolic pathways of different α-N-heterocyclic thiosemicarbazones

(2018) Karla Pelivan et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Aryl thiosemicarbazones for the treatment of trypanosomatidic infections

(2018) Pasquale Linciano et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of DNA binding and DNA cleavage of nickel(II) complexes with tridentate α-N-heterocyclic thiosemicarbazones ligands

(2018) JunGang Deng et al.   INORGANICA CHIMICA ACTA

Self-organized three dimensional architectures based on non-covalent interactions in square planar Cu(II) thiosemicarbazone: Solvent mediated crystallization and EPR based correlation study

(2018) Lincy Tom et al.   INORGANICA CHIMICA ACTA

Synthesis, spectral characterization and biological evaluation of some copper(II) complexes containing 4-oxo-4H-chromene-3-carbaldehyde-4( N )-substituted thiosemicarbazones

(2018) G. Kalaiarasi et al.   INORGANICA CHIMICA ACTA

Synthesis, spectroscopic characterization, crystal structure, and anti-bacterial activity of diorganotin(IV) complexes with 5-bromo-2-hydroxybenzaldehyde-N(4)-ethylthiosemicarbazone

(2018) M. A. Salam et al.   JOURNAL OF COORDINATION CHEMISTRY

Disulfide-masked iron prochelators: Effects on cell death, proliferation, and hemoglobin production

(2018) E.A. Akam et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis, characterization and cytotoxic activity of novel copper(II) complexes with aroylhydrazone derivatives of 2-Oxo-1,2-dihydrobenzo[ h ]quinoline-3-carbaldehyde

(2018) Eswaran Ramachandran et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Effects of polar substituents on the biological activity of thiosemicarbazone metal complexes

(2018) Franco Bisceglie et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Combining molecular docking and QSAR studies for modeling the anti-tyrosinase activity of aromatic heterocycle thiosemicarbazone analogues

(2018) Huanhuan Dong et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis, structures and mechanistic pathways of anticancer activity of palladium(ii) complexes with indole-3-carbaldehyde thiosemicarbazones

(2018) Jebiti Haribabu et al.   NEW JOURNAL OF CHEMISTRY

Water-Soluble Mono- and Binuclear Ru(η6-p-cymene) Complexes Containing Indole Thiosemicarbazones: Synthesis, DFT Modeling, Biomolecular Interactions, and In Vitro Anticancer Activity through Apoptosis

(2018) Jebiti Haribabu et al.   ORGANOMETALLICS

Copper complexes as prospective anticancer agents: in vitro and in vivo evaluation, selective targeting of cancer cells by DNA damage and S phase arrest

(2018) Dharmasivam Mahendiran et al.   RSC Advances

An investigation on 3-acetyl-7-methoxy-coumarin Schiff bases and their Ru(ii) metallates with potent antiproliferative activity and enhanced LDH and NO release

(2018) G. Kalaiarasi et al.   RSC Advances

Example of two novel thiocyanato bridged copper (II) complexes derived from substituted thiosemicarbazone ligand: Structural elucidation, DNA/albumin binding, biological profile analysis and molecular docking study

(2018) Niladri Biswas et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Study on the design, synthesis and structure-activity relationships of new thiosemicarbazone compounds as tyrosinase inhibitors

(2017) Senchuan Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease

(2017) Duraippandi Palanimuthu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel 2-pyridinecarboxaldehyde thiosemicarbazones Ga(III) complexes with a high antiproliferative activity by promoting apoptosis and inhibiting cell cycle

(2017) Jinxu Qi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Isatin-β-thiocarbohydrazones: Microwave-assisted synthesis, antitumor activity and structure-activity relationship

(2017) Moustafa T. Gabr et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-proliferative effects of copper(II) complexes with hydroxyquinoline-thiosemicarbazone ligands

(2017) Dominga Rogolino et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ruthenium(II) complexes of thiosemicarbazones: Synthesis, X-ray crystal structures, spectroscopy, electrochemistry, DFT studies and fluoride sensing properties

(2017) Bipinbihari Ghosh et al.   INORGANICA CHIMICA ACTA

An investigation on the DNA/protein binding, DNA cleavage and in vitro anticancer properties of SNO pincer type palladium(II) complexes with N-substituted isatin thiosemicarbazone ligands

(2017) Mathiyan Muralisankar et al.   INORGANICA CHIMICA ACTA

Binuclear zinc(II) complexes of N(4)-substituted bis(thiosemicarbazone) ligands incorporating hydroxyl group and their non-hydroxyl analogues

(2017) Sara Hosseinpour et al.   INORGANICA CHIMICA ACTA

Synthesis of 5-nitro-salicylaldehyde-N-substituted thiosemicarbazonates of copper(II): Molecular structures, spectroscopy, ESI-mass studies and antimicrobial activity

(2017) Tarlok S. Lobana et al.   INORGANICA CHIMICA ACTA

Ruthenium(II) complexes encompassing 2-oxo-1,2-dihydroquinoline-3-carbaldehyde thiosemicarbazone hybrid ligand: A new versatile potential catalyst for dehydrogenative amide synthesis

(2017) Sellappan Selvamurugan et al.   INORGANICA CHIMICA ACTA

Rhenium(I) tricarbonyl compounds of bioactive thiosemicarbazones: Synthesis, characterization and activity against Trypanosoma cruzi

(2017) Esteban Rodríguez Arce et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis, structural, optical band gap and biological studies on iron (III), nickel (II), zinc (II) and mercury (II) complexes of benzyl α-monoxime pyridyl thiosemicarbazone

(2017) R.A. Bedier et al.   JOURNAL OF MOLECULAR STRUCTURE

Half-sandwich ruthenium-arene complexes with thiophen containing thiosemicarbazones: Synthesis and structural characterization

(2017) Pelin Köse Yaman et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Synthesis, characterization, crystal structure and antiproliferative activity studies of Cu(II), Ni(II) and Co(II) complexes with 4-benzoyl-5-pyrazolones derived compounds

(2017) Elena Pahonţu et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Anticancer, antimicrobial, spectral, voltammetric and DFT studies with Cu(II) complexes of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone and its N(4)- substituted derivatives

(2017) Ercan Türkkan et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Orchestration of dynamic copper navigation – new and missing pieces

(2017) Helena Öhrvik et al.   Metallomics

Copper, nickel and zinc complexes of 3-acetyl coumarin thiosemicarbazone: Synthesis, characterization and in vitro evaluation of cytotoxicity and DNA/protein binding properties

(2017) K.N. Anees Rahman et al.   POLYHEDRON

Ruthenium(II/III) complexes of redox non-innocent bis(thiosemicarbazone) ligands: Synthesis, X-ray crystal structures, electrochemical, DNA binding and DFT studies

(2017) Bipinbihari Ghosh et al.   POLYHEDRON

Structure-Based Discovery of Thiosemicarbazone Metalloproteinase Inhibitors for Hemorrhage Treatment in Snakebites

(2017) Francis B. Ferreira et al.   ACS Medicinal Chemistry Letters

Three novel transition metal complexes of 6-methyl-2-oxo-quinoline-3-carbaldehyde thiosemicarbazone: synthesis, crystal structure, cytotoxicity, and mechanism of action

(2017) Bi-Qun Zou et al.   RSC Advances

Thiosemicarbazone scaffold for the design of antifungal and antiaflatoxigenic agents: evaluation of ligands and related copper complexes

(2017) Dominga Rogolino et al.   Scientific Reports

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

(2016) Danuta S. Kalinowski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Design, synthesis and biological evaluation of novel 4-phenoxy-6,7-disubstituted quinolines possessing (thio)semicarbazones as c-Met kinase inhibitors

(2016) Xin Zhai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent progress in multifunctional metal chelators as potential drugs for Alzheimer's disease

(2016) M. Amélia Santos et al.   COORDINATION CHEMISTRY REVIEWS

Structure–antiproliferative activity studies on l-proline- and homoproline-4-N-pyrrolidine-3-thiosemicarbazone hybrids and their nickel(ii), palladium(ii) and copper(ii) complexes

(2016) Aliona Dobrova et al.   DALTON TRANSACTIONS

Arylthiosemicarbazones as antileishmanial agents

(2016) José Ignacio Manzano et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of in vivo antioxidant, in vitro antibacterial, MRSA and antifungal activity of novel substituted isatin N- (2,3,4,6-tetra- O -acetyl-β -d- glucopyranosyl)thiosemicarbazones

(2016) Nguyen Dinh Thanh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Gold(III) complexes with ONS-Tridentate thiosemicarbazones: Toward selective trypanocidal drugs

(2016) Andressa R. Rettondin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance

(2016) Veronika F.S. Pape et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Four copper(II) compounds synthesized by anion regulation: Structure, anticancer function and anticancer mechanism

(2016) Zhenlei Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

α− N −heterocyclic thiosemicarbazone Fe(III) complex: Characterization of its antitumor activity and identification of anticancer mechanism

(2016) Yi Gou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

DNA(CT), protein(BSA) binding studies, anti-oxidant and cytotoxicity studies of new binuclear Ni(II) complexes containing 4(N)-substituted thiosemicarbazones

(2016) G . Kalaiarasi et al.   INORGANICA CHIMICA ACTA

Synthesis of Ni(II) complexes bearing indole-based thiosemicarbazone ligands for interaction with biomolecules and some biological applications

(2016) Jebiti Haribabu et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Synthesis, crystal structure, DNA and protein binding studies of novel binuclear Pd(II) complex of 6-methoxy-2-oxo-1,2-dihydroquinoline-3-carbaldehyde-4(N,N)-dimethylthiosemicarbazone

(2016) Ramachandran Eswaran et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Cytotoxic gallium complexes containing thiosemicarbazones derived from 9-anthraldehyde: Molecular docking with biomolecules

(2016) Floyd A. Beckford et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis and characterization of a new bioactive mono(thiosemicarbazone) ligand based on 3,5-diacetyl-1,2,4-triazol diketone and its palladium and platinum complexes

(2016) A.I. Matesanz et al.   POLYHEDRON

The anti-tumor activity of novel oxovanadium complexes derived from thiosemicarbazones and fluoro-phenanthroline derivatives

(2016) Wen Rui et al.   POLYHEDRON

Noble metals in medicine: Latest advances

(2015) Serenella Medici et al.   COORDINATION CHEMISTRY REVIEWS

Comprehensive insights into the structure and coordination behavior of thiosemicarbazone ligands: a computational assessment of the E–Z interconversion mechanism during coordination

(2015) M. Hossein Khalilian et al.   NEW JOURNAL OF CHEMISTRY

Syntheses, structures and biological evaluation of some transition metal complexes with a tetradentate benzamidine/thiosemicarbazone ligand

(2015) Thi Bao Yen Nguyen et al.   POLYHEDRON

Dichloroacetate and cancer: New home for an orphan drug?

(2014) Shyam Kankotia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Synthesis, biological evaluation and 3D-QSAR study of hydrazide, semicarbazide and thiosemicarbazide derivatives of 4-(adamantan-1-yl)quinoline as anti-tuberculosis agents

(2014) Sanjay R. Patel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploring the Anti-Cancer Activity of Novel Thiosemicarbazones Generated through the Combination of Retro-Fragments: Dissection of Critical Structure-Activity Relationships

(2014) Maciej Serda et al.   PLoS One

Synthesis, characterization, crystal structure and antimicrobial activity of copper(II) complexes with a thiosemicarbazone derived from 3-formyl-6-methylchromone

(2014) Diana-Carolina Ilies et al.   POLYHEDRON

Synthesis, DNA/protein binding and in vitro cytotoxic studies of new palladium metallothiosemicarbazones

(2013) R. Prabhakaran et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Advances in Copper Complexes as Anticancer Agents

(2013) Carlo Santini et al.   CHEMICAL REVIEWS

Synthesis, characterization and in vitro pharmacological evaluation of new water soluble Ni(II) complexes of 4N-substituted thiosemicarbazones of 2-oxo-1,2-dihydroquinoline-3-carbaldehyde

(2013) Eswaran Ramachandran et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Role of Substitution at Terminal Nitrogen of 2-Oxo-1,2-dihydroquinoline-3-Carbaldehyde Thiosemicarbazones on the Coordination Behavior and Structure and Biological Properties of Their Palladium(II) Complexes

(2013) Eswaran Ramachandran et al.   INORGANIC CHEMISTRY

Synthesis, spectral, X-ray crystallography, electrochemistry, DNA/protein binding and radical scavenging activity of new palladium(II) complexes containing triphenylarsine

(2013) P. Kalaivani et al.   INORGANICA CHIMICA ACTA

Synthesis, characterization and crystal structures of nickel(II), palladium(II) and copper(II) complexes with 2-furaldehyde-4-phenylthiosemicarbazone

(2013) Diana-Carolina Ilies et al.   POLYHEDRON

Synthesis and antioxidant activities of 2-oxo-quinoline-3-carbaldehyde Schiff-base derivatives

(2012) Ye Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mixed ligand palladium(ii) complexes of 6-methoxy-2-oxo-1,2-dihydroquinoline-3-carbaldehyde 4N-substituted thiosemicarbazones with triphenylphosphine co-ligand: Synthesis, crystal structure and biological properties

(2012) Eswaran Ramachandran et al.   DALTON TRANSACTIONS

Evaluation of DNA binding, antioxidant and cytotoxic activity of mononuclear Co(III) complexes of 2-oxo-1,2-dihydrobenzo[h]quinoline-3-carbaldehyde thiosemicarbazones

(2012) Eswaran Ramachandran et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Evaluation on the role of terminal N-substitution in 6-methoxy-2-oxo-1,2-dihydroquinoline-3-carbaldehyde thiosemicarbazones on the biological properties of new water-soluble nickel(ii) complexes

(2012) Eswaran Ramachandran et al.   RSC Advances

Effect of terminal N-substitution in 2-oxo-1,2-dihydroquinoline-3-carbaldehyde thiosemicarbazones on the mode of coordination, structure, interaction with protein, radical scavenging and cytotoxic activity of copper(ii) complexes

(2011) Duraisamy Senthil Raja et al.   DALTON TRANSACTIONS

Biological evaluation of a novel water soluble sulphur bridged binuclear copper(II) thiosemicarbazone complex

(2011) Duraisamy Senthil Raja et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization, crystal structure and DNA binding studies of Pd(II) complexes containing thiosemicarbazone and triphenylphosphine/triphenylarsine

(2011) Eswaran Ramachandran et al.   INORGANICA CHIMICA ACTA

Reduced drug accumulation is more important in acquired resistance against oxaliplatin than against cisplatin in isogenic colon cancer cells

(2010) Lars Ekblad et al.   ANTI-CANCER DRUGS

A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit

(2010) Timothy D. Cushing et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo

(2010) Chad N. Hancock et al.   FREE RADICAL BIOLOGY AND MEDICINE

Biological assays and noncovalent interactions of pyridine-2-carbaldehyde thiosemicarbazonecopper(II) drugs with [poly(dA–dT)]2, [poly(dG–dC)]2, and calf thymus DNA

(2010) Rebeca Ruiz et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

A New Class of Antitumortrans-Amine-Amidine-Pt(II) Cationic Complexes: Influence of Chemical Structure and Solvent on in Vitro and in Vivo Tumor Cell Proliferation

(2010) Cristina Marzano et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Ru(II)–DMSO complexes of ON/SN chelates: Synthesis, behavior of Schiff bases towards hydrolytic cleavage of CN bond, electrochemistry and biological activities

(2010) Viswanathan Mahalingam et al.   POLYHEDRON

Phase II study of 3-AP Triapine in patients with recurrent or metastatic head and neck squamous cell carcinoma

(2009) C. M. Nutting et al.   ANNALS OF ONCOLOGY

Metal‐based antitumor, cytotoxic and antimicrobial activity: pharmacological evaluation of Knoevenagel condensate β‐diketone Schiff base thiosemicarbazone Cu(II) and Zn(II) complexes

(2009) N. Raman et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Synthesis, crystal structure, DNA interaction and antioxidant activities of two novel water-soluble Cu(2+) complexes derivated from 2-oxo-quinoline-3-carbaldehyde Schiff-bases

(2009) Zeng-Chen Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, structure, electrochemistry and spectral characterization of (d-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich Ascites Carcinoma in Swiss albino mice

(2009) M.P. Sathisha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization antibacterial and antiproliferative activity of novel Cu(II) and Pd(II) complexes with 2-hydroxy-8-R-tricyclo[7.3.1.0.2,7]tridecane-13-one thiosemicarbazone

(2009) Tudor Rosu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Impact of Metal Coordination on Cytotoxicity of 3-Aminopyridine-2-carboxaldehyde Thiosemicarbazone (Triapine) and Novel Insights into Terminal Dimethylation

(2009) Christian R. Kowol et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors

(2009) Yu Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Heterocyclic substituted thiosemicarbazones and their Cu(II) complexes: Synthesis, characterization and studies of substituent effects on coordination and DNA binding

(2008) Marisa Belicchi-Ferrari et al.   POLYHEDRON

Dimethyl sulfoxide ruthenium(II) complexes of thiosemicarbazones and semicarbazone: Synthesis, characterization and biological studies

(2008) Viswanathan Mahalingam et al.   POLYHEDRON

Synthesis and antitumor studies on novel Co(II), Ni(II) and Cu(II) metal complexes of bis(3-acetylcoumarin)thiocarbohydrazone

(2007) M.P. Sathisha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY