Article
Cardiac & Cardiovascular Systems
Yijun Yang, Justin Kurian, Giana Schena, Jaslyn Johnson, Hajime Kubo, Joshua G. Travers, Chunya Kang, Anna Maria Lucchese, Deborah M. Eaton, Maoting Lv, Na Li, Lorianna G. Leynes, Daohai Yu, Fengzhen Yang, Timothy A. McKinsey, Raj Kishore, Mohsin Khan, Sadia Mohsin, Steven R. Houser
Summary: The study suggests that metabolic syndrome in obese pregnant women may lead to pathological cardiac remodeling, increasing the risk of chronic heart disorders.
Review
Biochemistry & Molecular Biology
John A. D'Elia, George P. Bayliss, Larry A. Weinrauch
Summary: Cardiorenal syndrome, the end-stage of heart failure and kidney disease combination, is a serious condition that is influenced by factors such as diabetes, hyperlipidemia, obesity, hypertension, and renal impairment. Current therapy focuses on improving hemodynamic factors destructive to both the heart and kidney, but there have been limited advances in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Deling Zou, Yanyu Li, Guangping Sun
Summary: Elevated circulating TMAO levels are associated with exacerbation of cardiac and renal dysfunction in rats with CRS2. Attenuation of TMAO can ameliorate cardiac and renal injury and prevent the progression of CRS2.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Roberto Aquilani, Roberto Maestri, Maurizia Dossena, Maria Teresa La Rovere, Daniela Buonocore, Federica Boschi, Manuela Verri
Summary: This retrospective study found that patients with cardiorenal syndrome type 2 had significantly reduced plasma amino acid concentrations, independent of the degree of glomerular filtration rate (GFR) damage, but correlated with hemodynamic variables.
Article
Cardiac & Cardiovascular Systems
Linda Hagmayer, Christina Mayer, Nadja Ebert, Kerstin Amann, Christoph Daniel
Summary: Chronic kidney disease (CKD) often leads to congestive heart failure (CHF) and left ventricular hypertrophy (LVH), contributing to increased mortality in CKD patients. This study investigated whether cardiovascular changes in CKD could be reversed by kidney transplantation. The results showed that while renal function normalized after transplantation, heart load and hypertrophy did not decrease. However, left ventricular wall thickness, fractional shortening, and ejection fraction were restored to normal levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cell Biology
Beatriz Delgado-Valero, Victoria Cachofeiro, Ernesto Martinez-Martinez
Summary: Cardiorenal syndrome describes the complex interaction between heart and kidney disease, with renal dysfunction posing a significant threat to cardiac patients. Fibrosis is a key factor in the progression of organ injury and is believed to play a crucial role in the pathophysiology of cardiorenal syndromes.
Article
Cell Biology
Migdalia Iglesias, Hao Wang, Meredith Krause-Hauch, Di Ren, Linda Ines Zoungrana, Zehui Li, Jie Zhang, Jin Wei, Nikita Yadav, Kshama Patel, Mohammad Kasim Fatmi, Ruisheng Liu, Edward J. Lesnefsky, Ji Li
Summary: Acute kidney injury (AKI) leads to acute cardiac injury and dysfunction in cardiorenal syndrome Type 3 (CRS3) through oxidative stress (OS). The stress-inducible Sestrin2 (Sesn2) protein reduces reactive oxygen species (ROS) accumulation and activates AMP-dependent protein kinase (AMPK) to regulate cellular metabolism and energetics during OS. Sesn2 levels and its protective effects decline in the aged heart. Antidiabetic drug metformin upregulates Sesn2 levels in response to ischemia-reperfusion (IR) stress. However, the role of metformin in CRS3 remains unknown. This study seeks to explore how the age-related decrease in cardiac Sesn2 levels contributes to cardiac intolerance to AKI-induced insults, and how metformin ameliorates CRS3 through Sesn2.
Article
Biochemistry & Molecular Biology
Anuson Poasakate, Putcharawipa Maneesai, Siwayu Rattanakanokchai, Sarawoot Bunbupha, Terdthai Tong-Un, Poungrat Pakdeechote
Summary: Genistein demonstrates a cardioprotective effect in hypertensive rats by preventing hypertension, cardiac remodeling, and dysfunction induced by L-NAME. The protective mechanism may involve the suppression of oxidative stress through the Ang II/AT(1)R/NADPH oxidase/TGF-beta 1 signaling pathway.
Article
Cell Biology
Maelle Plawecki, Nathalie Gayrard, Laura Jeanson, Anthony Chauvin, Anne-Dominique Lajoix, Jean-Paul Cristol, Bernard Jover, Fabrice Raynaud
Summary: Cardiac alteration due to chronic kidney disease is accompanied by tissue fibrosis, which involves myofibroblasts and endothelial to mesenchymal transitions. Additionally, obesity and insulin resistance exacerbate cardiovascular risk in chronic kidney disease (CKD). This study aimed to investigate how pre-existing metabolic disease and endothelial to mesenchymal transition contribute to cardiac fibrosis in CKD. Rats fed a cafeteria diet were found to be obese, hypertensive, and insulin resistant. CKD rats exhibited high levels of cardiac fibrosis, with collagen-1 and nestin expressions increased regardless of diet. Interestingly, rats with CKD and a cafeteria diet showed an increase in CD31 and alpha-SMA co-staining, suggesting the involvement of endothelial to mesenchymal transition in cardiac fibrosis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Guido Gembillo, Luca Visconti, Maria Ausilia Giusti, Rossella Siligato, Alessia Gallo, Domenico Santoro, Alessandro Mattina
Summary: Cardiorenal syndrome is a multi-organ disease involving complex interactions between the heart and kidney, with the use of specific biomarkers aiding in diagnosis, risk assessment, and prognosis determination.
Editorial Material
Biochemistry & Molecular Biology
Luca Sgarabotto, Verdiana Ravarotto, Lucia Federica Stefanelli, Martina Cacciapuoti, Paul A. Davis, Federico Nalesso, Lorenzo A. Calo
Summary: Two genetic tubulopathies, Bartter's (BS) and Gitelman's (GS) syndromes, exhibit activation of the angiotensin system (RAS) despite normo/hypotension and absent cardiac remodeling. Investigating BSGS patients reveals that BSGS is the opposite of hypertension. This understanding allows BSGS to be used as a human model to study RAS system pathways and oxidative stress in cardiovascular and renal remodeling and pathophysiology.
Review
Medicine, General & Internal
Oana Nicoleta Buliga-Finis, Anca Ouatu, Minerva Codruta Badescu, Nicoleta Dima, Daniela Maria Tanase, Patricia Richter, Ciprian Rezus
Summary: Cardiorenal syndrome is a complex multifactorial disease with significant morbidity and mortality worldwide. The bi-directional relationship between the heart and kidneys plays a crucial role in its development. Understanding the underlying mechanisms and identifying potential targets for treatment and diagnosis can improve prognosis in cardiorenal syndrome.
Review
Biochemistry & Molecular Biology
Piotr Lagosz, Jan Biegus, Szymon Urban, Robert Zymlinski
Summary: Cardiorenal syndrome (CRS) is a complex and heterogeneous spectrum of symptoms that has posed challenges for cardiologists for many years. The coexistence of heart failure (HF) and deteriorated renal function adds to these challenges and is a strong predictor of poor outcomes. However, with the development of new renal assessment methods, we now have the opportunity to treat CRS more effectively than ever before. This review focuses on explaining the pathophysiology, recent advances, and current practices of monitoring renal function in patients with acute CRS, aiming to improve patient care and guide treatment strategies.
Article
Cardiac & Cardiovascular Systems
Zhiqiu Xia, Neetha Nanoth Vellichirammal, Li Han, Lie Gao, Erika Boesen, Alicia M. Schiller, Peter R. Pellegrino, Steven J. Lisco, Chittibabu Guda, Irving H. Zucker, Han-Jun Wang
Summary: Cardiorenal syndrome type 2 (CRS2) is a chronic cardiovascular disease that usually leads to chronic kidney disease due to chronic heart failure (CHF). The cardiac spinal afferent reflex (CSAR) plays a critical role in the development of CRS2. Our study demonstrates that cardiac afferent ablation and renal denervation improve cardiac function, protect the kidneys, and increase long-term survival in a myocardial infarction model of CHF. This research is of significance in the development of a unique neuromodulation therapy for CHF patients.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Prachi Umbarkar, Anand P. Singh, Sultan Tousif, Qinkun Zhang, Palaniappan Sethu, Hind Lal
Summary: Nintedanib (NTB) is an FDA-approved tyrosine kinase inhibitor for pulmonary fibrosis, and study shows its potential in reducing cardiac fibrosis and improving cardiac function in a murine heart failure model, suggesting its promising application in treating HF patients.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medical Laboratory Technology
Vitali Koch, Christian Booz, Leon D. Gruenewald, Moritz H. Albrecht, Tatjana Gruber-Rouh, Katrin Eichler, Ibrahim Yel, Scherwin Mahmoudi, Jan-Erik Scholtz, Simon S. Martin, Christiana Graf, Thomas J. Vogl, Christophe Weber, Stefan E. Hardt, Norbert Frey, Evangelos Giannitsis
Summary: The study assessed the performance of D-dimer testing for ACS diagnosis and prediction of MI outcomes. The results showed that D-dimer concentrations were significantly different in patients with different levels of hs-cTnT. Higher D-dimer levels were associated with an increased risk of recurrent MI and all-cause mortality. D-dimer was an independent predictor of all-cause mortality and subsequent MI events. However, D-dimer did not significantly improve diagnostic performance unless values exceeded the 95th percentile.
CLINICAL BIOCHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Ali Amr, Marc Hinderer, Lena Griebel, Dominic Deuber, Christoph Egger, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Daniel Huhn, Jan Haas, Karen Frese, Marc Schweig, Ninja Marnau, Annika Kraemer, Claudia Durand, Florian Battke, Hans-Ulrich Prokosch, Michael Backes, Andreas Keller, Dominique Schroeder, Hugo A. Katus, Norbert Frey, Benjamin Meder
Summary: The PROMISE concept aims to democratize genetic data through transparent, secure, and patient-centric data management. In a pilot study, patients showed increased importance on genetic data safety and reported changes in attitude towards data handling after using the PROMISE app.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Moritz Biener, Evangelos Giannitsis, Katharina Hogrefe, Matthias Mueller-Hennessen, Hanna Froehlich, Hugo A. Katus, Norbert Frey, Lutz Frankenstein, Tobias Taeger
Summary: For stable outpatients, MID calculated from changes in hs-cTnT measured 365 +/- 120 days apart can help predict an uneventful clinical course.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Evangelos Giannitsis, Norbert Frey
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Thomas M. Helms, Christian A. Perings, Philipp Sommer, Friedrich Koehler, Norbert Frey, Stephan von Haehling, Christiane Tiefenbacher, Karin Rybak, Stefan Sack, Martin Stockburger
Summary: Telemedical services, particularly in cardiological telemedicine centers, have the potential to address the increasing burden of cardiovascular diseases such as chronic heart failure. By implementing a systematic quality management system, TMCs can ensure structured telemonitoring and treatment interventions lead to improved patient care while meeting legal and normative requirements.
Article
Cardiac & Cardiovascular Systems
Daniel Finke, Markus B. Heckmann, Susanna Wilhelm, Lukas Entenmann, Hauke Hund, Nina Bougatf, Hugo A. Katus, Norbert Frey, Lorenz H. Lehmann
Summary: The study reveals that cancer patients with reduced left ventricular function or elevated cardiac biomarkers have higher all-cause mortality. NT-proBNP is found to be significantly higher in cancer patients and predicts ACM more accurately compared to hs-cTnT. Risk factors for atherosclerosis, such as diabetes and age (>65 years), were significant predictors for increased ACM in cancer patients.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Hatim Seoudy, Jasmin Shamekhi, Lisa Voigtlaender, Sebastian Ludwig, Johanne Frank, Tim Kujat, Peter Bramlage, Baravan Al-Kassou, Atsushi Sugiura, Ashraf Yusuf Rangrez, Niklas Schofer, Thomas Puehler, Georg Lutter, Moritz Seiffert, Georg Nickenig, Lenard Conradi, Norbert Frey, Dirk Westermann, Jan -Malte Sinning, Derk Frank
Summary: This study evaluated the risk stratification ability of serum C-reactive protein to albumin ratio (CAR) in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR), and the results showed that CAR was associated with increased all-cause mortality.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Pharmacology & Pharmacy
Vitali Koch, Leon D. Gruenewald, Tatjana Gruber-Rouh, Simon Martin, Katrin Eichler, Christian Booz, Ibrahim Yel, Thomas J. Vogl, Kristina Buchner, Marco Hagenmueller, Winfried Maerz, Norbert Frey, Stefan E. Hardt, Johannes H. Riffel
Summary: This study found that HA treatment can improve cardiac function, reduce collagen accumulation, and produce positive molecular and tissue effects in the process of cardiac remodeling in rats. Combining HA with standard heart failure medication can further enhance the treatment effects.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elham Kayvanpour, Michael Wisdom, Maximilian K. Lackner, Farbod Sedaghat-Hamedani, Jes-Niels Boeckel, Marion Muller, Rose Eghbalian, Jan Dudek, Shirin Doroudgar, Christoph Maack, Norbert Frey, Benjamin Meder
Summary: Through experiments on zebrafish embryos and HEK293A cells, it was found that VARS2 depletion may lead to heart failure, CNS dysfunction, and skeletal muscle damage. VARS2-depleted cells showed reduced enzymatic activity, rearrangement of ETC complexes, activation of the ISR, and disruptions in mitochondrial FAO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fabrice F. Darche, Nina D. Ullrich, Ziqiang Huang, Michael Koenen, Rasmus Rivinius, Norbert Frey, Patrick A. Schweizer
Summary: “Novel protocols for the differentiation of hiPSC into cardiac pacemaker cells were established, with protocol E being the most efficient among them. The protocols were characterized by their ability to upregulate cardiac pacemaker-specific genes and induce excellent rate responsiveness to stimulation.”
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Amr Abdin, Johann Bauersachs, Samira Soltani, Matthias Eden, Norbert Frey, Michael Boehm
Summary: Heart failure remains a global healthcare challenge despite significant developments in pharmacotherapies. There are concerns regarding low medication dosages and incomplete drug classes in real-world settings, and current guidelines lack detailed recommendations. A practical approach algorithm is proposed to assist physicians in treating HF patients.
Article
Cardiac & Cardiovascular Systems
Samantha Fischer, Gabriele Romano, Lalith Sharan, Gregor Warnecke, Derliz Mereles, Matthias Karck, Raffaele De Simone, Sandy Engelhardt
Summary: The purpose of this study was to demonstrate the potential effects of using personalized silicone models for mitral valve repair (MVR) simulation one day prior to the actual surgical procedure. Based on preoperative 3D echocardiography recordings, flexible replicas of the pathological mitral valves were produced and used to simulate the upcoming MVR. The integration of personalized surgical planning into the clinical routine of 6 MVR cases with 3 different surgeons showed positive responses and benefits such as reduced inspection time and fewer sizing attempts.
ANNALS OF THORACIC SURGERY
(2023)
Article
Pharmacology & Pharmacy
Panagiotis Xynogalos, Ann-Kathrin Rahm, Sebastian Fried, Safak Chasan, Daniel Scherer, Claudia Seyler, Hugo A. Katus, Norbert Frey, Edgar Zitron
Summary: This study analyzed the effect of the antiarrhythmic drug verapamil on the inwardly rectifying potassium current of cardiomyocytes. The results showed that verapamil inhibited the Kir2.1, Kir2.2, and Kir2.3 channels, with the inhibition of Kir2.3 being a previously unknown finding. Further experiments revealed that the inhibition of Kir2.3 by verapamil was dependent on specific binding sites and interference with PIP2 activation. This finding provides a potential target for the development of selective antiarrhythmic drugs targeting Kir2.3 channels.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Pediatrics
Alexander Kovacevic, Sven F. Garbade, Friederike Hoerster, Georg F. Hoffmann, Matthias Gorenflo, Derliz Mereles, Stefan Koelker, Christian Staufner
Summary: This study finds that right ventricular dysfunction is common in propionic acidemia patients, with diastolic dysfunction being particularly prevalent. These functional abnormalities are closely associated with the clinical outcome of the patients.
Article
Cardiac & Cardiovascular Systems
Matthias Aurich, Julian Bucur, Johannes A. Vey, Sebastian Greiner, Fabian aus dem Siepen, Ute Hegenbart, Stefan Schoenland, Hugo A. Katus, Norbert Frey, Derliz Mereles
Summary: This study analyzed the prognostic value of clinical, laboratory, electrocardiography and echocardiographic parameters in patients with cardiac involvement in light chain (AL) amyloidosis. The study found that certain parameters, such as New York Heart Association-functional class, left ventricular global longitudinal strain, and N-terminal pro-B-type natriuretic peptide, were independently predictive of mortality in these patients.