Article
Pharmacology & Pharmacy
Micol Ferrara, Jessica Cusato, Elena Salvador, Alice Trentalange, Chiara Alcantarini, Mattia Trunfio, Elvira Stefania Cannizzo, Valeria Bono, Silvia Nozza, Amedeo De Nicolo, Alice Ianniello, Elisa De Vivo, Antonio D'Avolio, Giovanni Di Perri, Stefano Bonora, Giulia Marchetti, Andrea Calcagno
Summary: This study aimed to investigate the correlation between inflammation markers and antiretroviral drug concentrations in HIV-positive patients. The results showed that there was a correlation between plasma inflammation markers and antiretroviral drug concentrations, suggesting an interplay between drug penetration and persistent inflammation.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Matthew Weichseldorfer, Yvonne Affram, Alonso Heredia, Zahra Rikhtegaran-Tehrani, Mohammad M. Sajadi, Sumiko P. Williams, Yutaka Tagaya, Francesca Benedetti, Habib O. Ramadhani, Frank Denaro, Arshi Munawwar, Joseph Bryant, Davide Zella, Marvin Reitz, Fabio Romerio, Olga S. Latinovic
Summary: This study utilized a humanized mouse model with HIV-1 to analyze viral suppression and identify solid tissue reservoirs such as lymph nodes, brain, spleen, and liver. The findings suggest that these organs harbor residual infected cells, highlighting the importance of appropriate animal models for studying HIV-1 eradication efforts.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Infectious Diseases
Abraham Saborido-Alconchel, Ana Serna-Gallego, Luis E. Lopez-Cortes, Maria Trujillo-Rodriguez, Juan Manuel Praena-Fernandez, Montserrat Dominguez-Macias, Carmen Lozano, Esperanza Munoz-Muela, Nuria Espinosa, Cristina Roca-Oporto, Cesar Sotomayor, Marta Herrero, Alicia Gutierrez-Valencia, Luis F. Lopez-Cortes
Summary: This substudy compared the activity of dolutegravir/lamivudine with dolutegravir plus tenofovir alafenamide/emtricitabine (DTG + TAF/FTC) in the male genital tract. The study found no significant difference in the percentage of undetectable seminal plasma HIV-1-RNA after 12 weeks of treatment between the two groups of treatment-naive individuals living with HIV.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Immunology
Sumbul Asif, Evangelia Baxevanidi, Andrew Hill, Willem Daniel Francois Venter, Lee Fairlie, Masebole Masenya, Celicia Serenata, Simiso Sokhela, Nomathemba Chandiwana
Summary: This study aimed to predict the risk of adverse pregnancy outcomes caused by treatment-associated obesity using a hypothetical sample based on the ADVANCE trial. The results indicated that women using integrase inhibitors, especially when combined with tenofovir alafenamide, were more likely to experience obesity and subsequently higher risks of adverse pregnancy outcomes. Further research is needed to monitor and address the ongoing weight gain associated with treatment to mitigate these risks.
Article
Medicine, General & Internal
Shahin Lockman, Sean S. Brummel, Lauren Ziemba, Lynda Stranix-Chibanda, Katie McCarthy, Anne Coletti, Patrick Jean-Philippe, Ben Johnston, Chelsea Krotje, Lee Fairlie, Risa M. Hoffman, Paul E. Sax, Sikhulile Moyo, Nahida Chakhtoura, Jeffrey S. A. Stringer, Gaerolwe Masheto, Violet Korutaro, Haseena Cassim, Blandina T. Mmbaga, Esau Joao, Sherika Hanley, Lynette Purdue, Lewis B. Holmes, Jeremiah D. Momper, Roger L. Shapiro, Navdeep K. Thoofer, James F. Rooney, Lisa M. Frenkel, K. Rivet Amico, Lameck Chinula, Judith Currier
Summary: This study compared the safety and efficacy of three antiretroviral regimens started in pregnancy. The dolutegravir-containing regimens had superior virological efficacy at delivery compared with the efavirenz-containing regimen and the dolutegravir, emtricitabine, and tenofovir disoproxil fumarate regimen. The dolutegravir, emtricitabine, and tenofovir alafenamide fumarate regimen had the lowest frequency of composite adverse pregnancy outcomes and of neonatal deaths.
Article
Infectious Diseases
Alba Rocabert, Beatriz Borjabad, Leire Berrocal, Jordi Blanch, Alexy Inciarte, Ivan Chivite, Ana Gonzalez-Cordon, Berta Torres, Juan Ambrosioni, Maria Martinez-Rebollar, Montserrat Laguno, Lorena De La Mora, Alberto Foncillas, Abiu Sempere, Ana Rodriguez, Estela Solbes, Roger Llobet, Jose M. Miro, Josep Mallolas, Jose L. Blanco, Elisa De Lazzari, Esteban Martinez
Summary: Switching to BIC/TAF/FTC or dolutegravir/lamivudine showed no difference in the risks of overall or toxicity-related discontinuations or in the profile of adverse events leading to discontinuation.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Immunology
Hylke Waalewijn, Alexander J. Szubert, Roeland E. Wasmann, Lubbe Wiesner, Chishala Chabala, Mutsa Bwakura-Dangarembizi, Shafic Makumbi, Joan Nangiya, Vivian Mumbiro, Veronica Mulenga, Victor Musiime, Lara N. Monkiewicz, Anna L. Griffiths, Alasdair Bamford, Katja Doerholt, Paolo Denti, David M. Burger, Diana M. Gibb, Helen M. McIlleron, Angela Colbers
Summary: In a pharmacokinetic substudy of the CHAPAS-4 trial in African children, it was found that the combination of TAF and tenofovir, when dosed according to WHO-recommended weight bands and combined with dolutegravir or ritonavir-boosted protease inhibitors, provided adequate exposure and efficacy.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Nutrition & Dietetics
Yonghwan Jung, Jin Sook Song, Sunjoo Ahn
Summary: This study provides the first pharmacokinetic evaluation of succinic acid after a single dose in mice, demonstrating its clearance, volume of distribution, terminal half-life, as well as tissue distribution in different organs.
Article
Multidisciplinary Sciences
Claudia D. Frola, Ines Aristegui, Maria I. Figueroa, Pablo Radusky, Nadir Cardozo, Virginia Zalazar, Carina Cesar, Patricia Patterson, Valeria Fink, Ana Gun, Pedro Cahn, Omar Sued
Summary: In Argentina, transgender women (TGW) have a high HIV prevalence (34%) and poorer outcomes compared to cisgender patients. A study was conducted to evaluate the effectiveness of dolutegravir (DTG)-based treatment among naive TGW, with promising results of high retention, adherence, and viral suppression at 48 weeks.
Article
Pharmacology & Pharmacy
Asama Tanaudommongkon, Ayyappa Chaturvedula, Craig W. Hendrix, Edward J. Fuchs, Eugenie Shieh, Rahul P. Bakshi, Mark A. Marzinke
Summary: This study used pharmacokinetic models to analyze the differences in concentration of emtricitabine/tenofovir disoproxil fumarate (F/TDF) parent-metabolite between transgender women (TGW) on gender-affirming hormonal therapies (GAHT) and cisgender men (CGM) not exposed to GAHT. Simulations revealed that TGW should receive treatment for at least 2 weeks to achieve comparable exposure to CGM.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Yue Li, Teng Wang, Hao-Hao Shi, Yu-Ming Wang, Chang-Hu Xue, Qing-Rong Huang, Tian-Tian Zhang
Summary: Sea cucumber-derived sulfated sterols showed more significant bioactivities due to the unique structure of the sulfate group, but their absorption, pharmacokinetics, and tissue distribution remain unknown. This study investigated the absorption characteristics, pharmacokinetics, and tissue distribution of sea cucumber sterols, finding that they are absorbed quickly and mainly accumulate in the liver. These results provide insights for the development of functional foods and nutraceuticals containing sea cucumber sterols.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Ines Mendoza, Alicia Lazaro, Alfredo Espinosa, Lorenzo Sanchez, Ana Maria Horta, Miguel Torralba
Summary: This study shows that dolutegravir plus lamivudine (2-DR) is not as effective as bictegravir/emtricitabine/tenofovir alafenamide (3-DR) in treating HIV-1. However, the durability and safety of 2-DR are similar to 3-DR.
Article
Chemistry, Medicinal
Shuliang Song, Qiang Wei, Ke Wang, Qiong Yang, Yu Wang, Aiguo Ji, Guanjun Chen
Summary: This study used fluorescently labeled PM to investigate its distribution and pharmacokinetics in vivo. The results showed that FITC-PM had high stability and tended to be distributed in the kidney, liver, and at lower concentrations in the heart, spleen, and lungs after tail vein injection. Pharmacokinetic analysis revealed appropriate elimination rate constant, half-life time, and clearance rate for FITC-PM. The studies of pharmacokinetics and tissue distribution provided basic information that can be used to further clarify the pharmacodynamic mechanisms of PM.
Article
Microbiology
Julie Bertrand, Aurelie Barrail-Tran, Lucie Fayette, Rada Savic, Cecile Goujard, Elina Teicher, Caroline Barau, Alain Pruvost, Anne-Marie Taburet, France Mentre, Celine Verstuyft, A. Barrail-Tran, A. Brunet, M. -J. Commoy, S. Couffin-Cadiergues, D. Descamps, X. Duval, C. Goujard, C. Le Guellec, F. Mentre, G. Nembot, A. -M. Taburet, B. Vrijens, G. Nembot, G. Unal, F. Mentre, X. Panhard, R. Savic, B. Vrijens
Summary: A model was established to predict the plasma concentrations of Tenofovir and emtricitabine, and it was found that the clearance of these drugs decreases with age, but is not significantly associated with specific gene polymorphisms. The model can be used to predict the concentrations of TFV-DP and FTC-TP after switching to alternative regimens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Immunology
Anchalee Avihingsanon, Hongzhou Lu, Chee Loon Leong, Chien-Ching Hung, Ellen Koenig, Sasisopin Kiertiburanakul, Man-Po Lee, Khuanchai Supparatpinyo, Fujie Zhang, Sophia Rahman, Michelle L. D'Antoni, Hongyuan Wang, Jason T. Hindman, Hal Martin, Jared M. Baeten, ALLIANCE Study Team
Summary: This study compared the viral suppression effects of bictegravir, emtricitabine, and tenofovir alafenamide with dolutegravir, emtricitabine, and tenofovir disoproxil fumarate in individuals with HIV-1 and HBV coinfection. The results showed that bictegravir, emtricitabine, and tenofovir alafenamide were non-inferior to dolutegravir, emtricitabine, and tenofovir disoproxil fumarate in achieving viral suppression at 48 and 96 weeks, with comparable safety profiles.
Article
Immunology
Jennifer Gorwood, Christine Bourgeois, Valerie Pourcher, Guillaume Pourcher, Frederic Charlotte, Matthieu Mantecon, Cindy Rose, Romain Morichon, Michael Atlan, Roger Le Grand, Delphine Desjardins, Christine Katlama, Bruno Feve, Olivier Lambotte, Jacqueline Capeau, Veronique Bereziat, Claire Lagathu
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Cell Biology
Jennifer Gorwood, Tina Ejlalmanesh, Christine Bourgeois, Matthieu Mantecon, Cindy Rose, Michael Atlan, Delphine Desjardins, Roger Le Grand, Bruno Feve, Olivier Lambotte, Jacqueline Capeau, Veronique Bereziat, Claire Lagathu
Article
Oncology
Luca Cassetta, Kirsten Bruderek, Joanna Skrzeczynska-Moncznik, Oktawia Osiecka, Xiaoying Hu, Ida Marie Rundgren, Ang Lin, Kim Santegoets, Utku Horzum, Ana Godinho-Santos, Gennadiy Zelinskyy, Thalia Garcia-Tellez, Suncica Bjelica, Bartlomiej Taciak, Astrid Olsnes Kittang, Benedikt Hoeing, Stephan Lang, Michael Dixon, Verena Mueller, Jochen Sven Utikal, Derya Karakoc, Kerim Bora Yilmaz, Emilia Gorka, Lubomir Bodnar, Olympia Evdoxia Anastasiou, Christine Bourgeois, Robert Badura, Monika Kapinska-Mrowiecka, Mirjana Gotic, Mark ter Laan, Esther Kers-Rebel, Magdalena Krol, Juan Francisco Santibanez, Michaela Mueller-Trutwin, Ulf Dittmer, Ana Espada de Sousa, Gunes Esendagli, Gosse Adema, Karin Lore, Elisabeth Ersvaer, Viktor Umansky, Jeffrey W. Pollard, Joanna Cichy, Sven Brandau
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Medicine, General & Internal
Sophie Novelli, Camille Lecuroux, Cecile Goujard, Jacques Reynes, Agnes Villemant, Laurent Blum, Asma Essat, Veronique Avettand-Fenoel, Odile Launay, Jean-Michel Molina, Christine Bourgeois, Laurence Meyer
Article
Immunology
Anaelle Olivo, Camille Lecuroux, Marie Bitu, Veronique Avettand-Fenoel, Faroudy Boufassa, Asma Essat, Laurence Meyer, Jean-Marc Doisne, Benoit Favier, Bruno Vaslin, Geraldine Schlecht-Louf, Nicolas Noel, Cecile Goujard, Olivier Lambotte, Christine Bourgeois
Summary: New ways to characterize CD8(+) memory T cell responses in chronic HIV infection are based on measuring chemokine receptor expression. The study found that in chronic controlled HIV infection, the proportions of different chemokine receptor expressing CD8(+) T cells were impacted, leading to differences in exhaustion and senescence phenotypes. The addition of migration markers contributes to better characterize Tcm/Tem compartment in HIV infection.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Infectious Diseases
Thibaut Gele, Antoine Cheret, Alicia Castro Gordon, Lionelle Nkam, Valerie Furlan, Coralie Pallier, Pierre-Hadrien Becker, Pilartxo Catalan, Cecile Goujard, Anne-Marie Taburet, Jacques Gasnault, Helene Gouget, Aurelie Barrail-Tran
Summary: This study aimed to determine the concentrations of bictegravir, emtricitabine and tenofovir in the cerebrospinal fluid of HIV patients with CNS impairment, finding low exposure of these drugs in the CSF. The results suggest caution should be exercised when using BIC/FTC/TAF as first-line treatment for HIV patients with HCI under the age of 51.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Immunology
Philippe Horellou, Alienor de Chalus, Laetitia Giorgi, Carole Leroy, Pascale Chretien, Salima Hacein-Bey-Abina, Christine Bourgeois, Xavier Mariette, Che Serguera, Roger Le Grand, Kumaran Deiva
Summary: The study identified differences in MOG antigenic immunological response among MOGAD, MS, and control patients, as well as between relapsing and non-relapsing subgroups of MOGAD. CD4(+) Th2 and Th17 cells were found to be involved in the pathophysiology of MOGAD in children, while the opposite response of T-regs to rh-MOG in relapsing and non-relapsing MOGAD patients may explain relapses in this recurrent pediatric autoimmune disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Chris Wymant, Daniela Bezemer, Francois Blanquart, Luca Ferretti, Astrid Gall, Matthew Hall, Tanya Golubchik, Margreet Bakker, Swee Hoe Ong, Lele Zhao, David Bonsall, Mariateresa de Cesare, George MacIntyre-Cockett, Lucie Abeler-Doerner, Jan Albert, Norbert Bannert, Jacques Fellay, M. Kate Grabowski, Barbara Gunsenheimer-Bartmeyer, Huldrych F. Gunthard, Pia Kivela, Roger D. Kouyos, Oliver Laeyendecker, Laurence Meyer, Kholoud Porter, Matti Ristola, Ard van Sighem, Ben Berkhout, Paul Kellam, Marion Cornelissen, Peter Reiss, Christophe Fraser
Summary: A highly virulent variant of subtype-B HIV-1 was discovered in the Netherlands. Infected individuals with this variant had significantly higher viral loads and faster decline in CD4 cells compared to other subtype-B strains. The increased virulence is attributed to the viral strain, and the variant emerged in the 1990s with increased transmissibility and an unfamiliar molecular mechanism of virulence.
Article
Immunology
Julien Lemaitre, Delphine Desjardins, Anne-Sophie Gallouet, Mario Gomez-Pacheco, Christine Bourgeois, Benoit Favier, Asier Saez-Cirion, Roger Le Grand, Olivier Lambotte
Summary: Despite the effectiveness of combinational antiretroviral treatment (cART), HIV-1 still persists in the host, causing chronic inflammation and increasing the risk of comorbidities. Myeloid cells, particularly monocytes and macrophages, have been studied in HIV-1 infection, while neutrophils, the most abundant circulating myeloid cell, have received less attention. This study characterizes the phenotype of neutrophils during SIVmac251 experimental infection and reveals their role in modulating T-cell responses. The findings highlight the significance of primed immature neutrophils in SIV infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Anaelle Olivo, Romain Marlin, Thierry Lazure, Pauline Maisonnasse, Laetitia Bossevot, Christelliah Mouanga, Julien Lemaitre, Guillaume Pourcher, Stephane Benoist, Roger Le Grand, Olivier Lambotte, Nathalie Dereuddre-Bosquet, Christine Bourgeois
Summary: There is a documented association between obesity and the severity of SARS-CoV-2 infection. This study found that SARS-CoV-2 can be detected in subcutaneous adipose tissue but not in visceral adipose tissue or epicardial adipose tissue in a model of mild infection. The study also observed higher levels of angiotensin-converting-enzyme-2 mRNA expression in subcutaneous adipose tissue compared to visceral adipose tissue. Additionally, both subcutaneous and visceral adipose tissue showed a reduction in CD69 expression in T cells after SARS-CoV-2 infection.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cell Biology
Kenza Ngono Ayissi, Jennifer Gorwood, Laura Le Pelletier, Christine Bourgeois, Carine Beaupere, Martine Auclair, Roberta Foresti, Roberto Motterlini, Michael Atlan, Aurelie Barrail-Tran, Roger Le Grand, Delphine Desjardins, Bruno Feve, Olivier Lambotte, Jacqueline Capeau, Veronique Bereziat, Claire Lagathu
Summary: Treatment with integrase-strand-transfer-inhibitors (INSTIs) can lead to adipose tissue gain and fibrosis, inhibiting beiging in adipose tissue and resulting in obesity and insulin resistance.
Article
Pharmacology & Pharmacy
Thibaut Gele, Helene Gouget, Nathalie Dereuddre-Bosquet, Valerie Furlan, Roger Le Grand, Olivier Lambotte, Delphine Desjardins, Aurelie Barrail-Tran
Summary: This study utilized a non-human primate model treated with long-term antiretroviral drugs to investigate immunological, virological, and pharmacological factors in the management of HIV infection. The results indicated that the model is suitable for studying pharmacological sanctuaries in HIV infection and exploring strategies for an HIV cure.
Article
Medicine, Research & Experimental
Federico Perdomo-Celis, Caroline Passaes, Valerie Monceaux, Stevenn Volant, Faroudy Boufassa, Pierre de Truchis, Morgane Marcou, Katia Bourdic, Laurence Weiss, Corinne Jung, Christine Bourgeois, Cecile Goujard, Laurence Meyer, Michaela Muller-Trutwin, Olivier Lambotte, Asier Saez-Cirion
Summary: Virus-specific CD8(+) T cells play a central role in HIV-1 control and can be reprogrammed to enhance their antiviral potential through targeting specific signaling pathways.
JOURNAL OF CLINICAL INVESTIGATION
(2022)