Article
Engineering, Multidisciplinary
Ping Song, Mingxin Li, Boqing Zhang, Xingyu Gui, Yanlong Han, Li Wang, Wenzheng Zhou, Likun Guo, Zhenyu Zhang, Zhengyong Li, Changchun Zhou, Yujiang Fan, Xingdong Zhang
Summary: This study aimed to prepare high-precision GelMA/HAp composite scaffolds using digital light processing (DLP) printing for bone repair. GelMA hydrogels with adjustable properties were synthesized, and suitable dispersants were selected to reduce the agglomeration of HAp. The printed composite scaffolds with excellent mechanical strength showed promotion of osteoblast adhesion, proliferation, and differentiation in vitro. In vivo experiments on rabbit skull defects demonstrated the ability of the composite scaffolds to accelerate new bone formation. The GelMA/HAp porous composite scaffolds fabricated by composite inks with good printability, mechanical properties, and osteogenic activity have great potential in bone repair applications.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Materials Science, Composites
Heba Kandil, Basma Ekram, Mona A. M. Abo-Zeid, Bothaina M. Abd M. El-Hady, Amal Amin
Summary: A promising modified composite scaffold for bone tissue engineering was synthesized, which consisted of hydroxyapatite, hyperbranched polyitaconic acid, and chitosan. The modified scaffold showed improved mechanical strength and bioactivity, as well as anticancer properties and enhanced human skin fibroblasts proliferation.
POLYMER COMPOSITES
(2023)
Article
Materials Science, Multidisciplinary
Tanatsaparn Tithito, Chantiga Choochottiros, Jirawan Thongbunchoo, Narattaphol Charoenphandhu, Nateetip Krishnamra, Weeraphat Pon-On
Summary: This study fabricated a composite scaffold of trace element-incorporated hydroxyapatite (THA) integrated bioactive gel (BioGel), which showed desirable porous structure and mechanical strength. It was found to effectively promote bone formation and attachment of osteoblast-like cells.
Article
Biochemistry & Molecular Biology
Piyachat Chuysinuan, Patcharakamon Nooeaid, Thanyaluck Thanyacharoen, Supanna Techasakul, Prasit Pavasant, Kavita Kanjanamekanant
Summary: The study demonstrates the potential use of synthetic HA-incorporated fibroin-alginate hydrogel as a scaffold for bone regeneration in dentistry, showing good biocompatibility. The hydrogel exhibits high swelling ratio and degradation properties in vitro, but further in vivo studies are needed to validate its clinical application potential.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Pariya Zare, Mohamad Pezeshki-Modaress, Seyed Mohammad Davachi, Pouria Zare, Fatemeh Yazdian, Sara Simorgh, Hadi Ghanbari, Hamid Rashedi, Zohreh Bagher
Summary: In this study, two different arrangements of laminated composite scaffolds were fabricated based on Alginate, showcasing improved mechanical features and sustained drug release. The optimized scaffold displayed advantages such as interconnected pores, controlled biodegradability, and no cytotoxic effect, making it a promising candidate for tissue regeneration.
CARBOHYDRATE POLYMERS
(2021)
Article
Nanoscience & Nanotechnology
Pengfei Cai, Chunchun Li, Yangfan Ding, Hanting Lu, Xiao Yu, Jie Cui, Fan Yu, Hongsheng Wang, Jinglei Wu, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Liang Song, Xiumei Mo, Binbin Sun
Summary: This research introduces a novel method that combines electrospun nanofibers with 3D printing techniques to fabricate composite scaffolds for bone defect treatment. Compared to nanoparticle-reinforced scaffolds, these scaffolds infused with nanofibers exhibit superior mechanical attributes and bioactivity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Yunfei Tan, Lei Ma, Xiangyu Chen, Yaqin Ran, Qiulan Tong, Liwen Tang, Xudong Li
Summary: The interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in natural polysaccharide/hydroxyapatite hydrogels remains a challenge in bone tissue engineering. In this study, hyaluronic acid was used as a template for biological mineralization to synthesize hyaluronic acid/hydroxyapatite hybrid particles. These particles were then introduced into hydroxyapatite composite hydrogels, which showed increased storage modulus and excellent cytocompatibility. The self-healing hydrogels, suitable for cell encapsulation, hold promise for bone defect repair.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Multidisciplinary
Ahmad Saudi, Seyed Mojtaba Zebarjad, Hossein Salehi, Elham Katoueizadeh, Aliakbar Alizadeh
Summary: The study examined the morphology, surface contact angle, mechanical properties, in vitro degradation behavior, and water uptake of PCL/PGS/HAp fibers, showing that HAp particles have a positive effect on PC12 viability and adhesion.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Materials Science, Multidisciplinary
Md. Kaiser Haider, Lei Sun, Azeem Ullah, Sana Ullah, Yuji Suzuki, Soyoung Park, Yo Kato, Yasushi Tamada, Ick Soo Kim
Summary: The study fabricated composite nanofibrous scaffolds from blends of PAN, nCB, and HA via electrospinning to observe the effect of nCB on membrane properties. The results showed that the addition of nCB reduced the average diameter of nanofibers and improved the mechanical performance of the scaffold. Excellent mineralization and biocompatibility were observed, indicating strong potential for use as bone and hard tissue restoring materials.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Tierong Bian, Ni Pang, Hongyun Xing
Summary: A parallel-aligned beta-tricalcium phosphate/collagen composite nanofiber scaffold with a microstructure similar to natural bone matrix membrane was fabricated, and crosslinked with glutaraldehyde to enhance its stability. The scaffold not only promotes biomimetic apatite-like mineral deposition and bone integration during repair, but also exhibits compatibility with bone marrow mesenchymal stem cells and strong antibacterial activity against E.coli. This composite nanofiber scaffold provides a new bioactive bone scaffold material for bone defect repair with antibacterial properties.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Materials Science, Multidisciplinary
Mohammed Lakrat, Mohammed Jabri, Marta Alves, Maria H. Fernandes, Lhaj Lahcen Ansari, Catarina Santos, El Miloud Mejdoubi
Summary: The study introduced a novel consolidation process using sodium silicate solution as a mineral binder at near-room temperature, preserving the important characteristics of low crystallinity, non-stoichiometry, and nanosize of n-HAp for bone tissue engineering applications. The consolidated 3D composite scaffold showed appropriate porosity and mechanical properties, alongside non-hazardous and inductive nature towards osteoblast-like cell lines, indicating enhanced cell proliferation for potential bone-healing applications.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Fatemeh Hakimi, Hamed Jafari, Samaneh Hashemikia, Siamak Shabani, Ali Ramazani
Summary: This study aimed to prepare a novel organic-mineral nanofiber/hydrogel of chitosan-polyethylene oxide (CS-PEO)/nanoclay-alginate (NC-ALG) and investigate its effects on mineralization and biocompatibility. The scaffolds composed of CS-PEO and NC-ALG were evaluated for their properties and characteristics. The results showed that the incorporation of NC particles in the scaffold enhanced bone-like apatite formation and demonstrated compatibility and safety for osteoblastic cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Fan Fei, Haiyan Yao, Yujiang Wang, Junchao Wei
Summary: Poly(lactide)/graphene oxide/parathyroid hormone (1-34) nanofiber membranes were prepared and showed improved tensile strength and alkaline phosphatase activity, making them promising candidate materials for bone tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Sihan Zhang, Guanglei Zhao, Wei Ma, Yanghui Song, Cheng Huang, Chong Xie, Kebing Chen, Xiaofeng Li
Summary: A porous chitosan nanofiber scaffold (CSNFS) with an extracellular matrix-like structure was prepared through a cross-linking reaction, showing high porosity and adequate micro-scale pores. CSNFS has good mechanical strength and biocompatibility, and can be used as a repair material for bone tissue engineering.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Ceramics
Melike Nur Ozder, Fatih Ciftci, Ozge Rencuzogullari, Elif Damla Arisan, Cem Bulent Ustundag
Summary: This study investigates the properties of in situ synthesis of graphene oxide-hydroxyapatite (GO/HA) nanocomposite materials with different doping ratios for bone tissue support applications. The results show that scaffolds containing 0.5% and 1% GO (w/w) exhibit excellent cell proliferation and adhesion, making them promising materials for bone support applications.
CERAMICS INTERNATIONAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Suryani Dyah Astuti, Irawan Budi Utomo, Ernie Maduratna Setiawatie, Miratul Khasanah, Hery Purnobasuki, Deny Arifianto, Kartika Anggraini Alamsyah
Summary: This study aimed to investigate the therapeutic effects of the combination treatment of 405 nm diode laser and 0.1% doxycycline on periodontitis in a rat model. Results showed that the combination treatment had immunomodulatory effects and exerted a healing effect on day 5 and 7 in rat models of periodontitis.
Article
Materials Science, Multidisciplinary
Mona Sari, Puspa Hening, Chotimah, Ika Dewi Ana, Yusril Yusuf
Summary: Bioceramic carbonated hydroxyapatite (CHA) was successfully synthesized from abalone mussel shells, and scaffolds with excellent pore structure and biocompatibility were fabricated, showing positive effects on bone cell growth.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Suryani Dyah Astuti, Age Sulistyo, Ernie Maduratna Setiawatie, Miratul Khasanah, Hery Purnobasuki, Deny Arifianto, Yunus Susilo, Kartika Anggraini Alamsyah, Suhariningsih, Ardiyansyah Syahrom
Summary: Red diode laser at 649 nm accelerates proliferation in wound healing post molar extraction, increasing lymphocyte and fibroblast cells, new blood vessels formation, and Colagen-1 alpha expression while decreasing Interleukin-1 beta expression. Blue laser also shows positive effects on wound healing with lower tissue penetration compared to red laser.
Article
Materials Science, Multidisciplinary
Mona Sari, Nicholas Adi Kristianto, Chotimah, Ika Dewi Ana, Yusril Yusuf
Summary: Carbonated hydroxyapatite based on abalone mussel shells was successfully synthesized and used for coating on a Titanium alloy. The electrophoretic deposition dip coating method was employed to coat the hydroxyapatite on the Titanium alloy surface, creating a potential coating for bone implant applications.
Article
Dentistry, Oral Surgery & Medicine
Mona Sari, Dewi Monica Ramadhanti, Rizki Amalina, Chotimah, Ika Dewi Ana, Yusril Yusuf
Summary: Nano-hydroxyapatite was synthesized from abalone mussel shells and gel HA-Abalone was developed. Gel HA-Abalone with a concentration of 20wt% showed the best remineralization effect on the superficial layer. Cell viability assay revealed that cell growth was inhibited at a gel concentration of 1,000μg/mL.
DENTAL MATERIALS JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Mona Sari, Aminatun, Tri Suciati, Yessie Widya Sari, Yusril Yusuf
Summary: Porosity is an important parameter for scaffold pore structure in the fabrication of carbonated hydroxyapatite (CHA) using paraffin wax as a synthetic polymer. The addition of 30% paraffin wax in CHA synthesis showed potential for cellular growth orientation in the scaffold, while increasing paraffin wax concentrations led to a decrease in the crystallographic properties of the nanocomposite scaffold.
Article
Materials Science, Biomaterials
Luthfia Anindya Yuwono, Siswanto, Mona Sari, Yusril Yusuf, Tri Suciati, Yessie Widya Sari, Che Azurahanim Che Abdullah, Aminatun
Summary: In this study, a bone scaffold composed of hydroxyapatite (HA)-polycaprolactone (PCL)-collagen was fabricated to promote bone remodeling and healing. The HA/PCL/collagen 50:25:25 (F3) sample exhibited the best characteristics as a bone scaffold candidate.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Aminatun Nisa, Mona Sari, Yusril Yusuf
Summary: This study aims to develop gel composites for remineralization gel in teeth by synthesizing and characterizing hydroxyapatite (HA) from oyster shell. The HA- propolis gel composite showed the best antibacterial activity and significant cell growth, indicating its potential in improving dental enamel caries.
MATERIALS RESEARCH EXPRESS
(2022)
Article
Biotechnology & Applied Microbiology
Mona Sari, Chotimah, Ika Dewi Ana, Yusril Yusuf
Summary: In this study, CHA/Ti and CHA/HCB/Ti plates were coated using the EP2D method, and the cell viability and surface morphology of the coatings were analyzed. The results showed that the cell viability of CHA/Ti plates was superior to that of CHA/HCB/Ti plates, and the surface of CHA/Ti remained unchanged after the coating process. These findings are important for biomedical applications, especially in the field of bone implants.
BIOENGINEERING-BASEL
(2022)
Article
Nanoscience & Nanotechnology
W. Sari, M. Sari, Y. Yusuf
Summary: In this study, a hydroxyapatite-based scaffold was fabricated and characterized using natural polymers (honeycomb) and paraffin wax. The morphology and properties of the scaffold were influenced by the calcination temperature, which also affected the crystallite size and porosity. The results showed that the crystallite size decreased with increasing calcination temperature for both types of scaffold. Additionally, HA/HCB scaffold at 900℃ exhibited interconnected pores and small porosity, while HA/Wax scaffold at the same temperature had fewer interconnected pores and non-uniform particles.
ADVANCES IN NATURAL SCIENCES-NANOSCIENCE AND NANOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Mona Sari, Puspa Hening, Chotimah, Ika Dewi Ana, Yusril Yusuf
Summary: This study evaluated the effect of HCB concentration on the macropore structure of the scaffolds. The results showed that 30% HCB is the optimal concentration, meeting the criteria for pore structure, crystallographic properties, chemical decomposition process, and cell viability for bone tissue engineering.
BIOMATERIALS RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Hestining A. Permatasari, Mona Sari, Aminatun, Tri Suciati, Kiagus Dahlan, Yusril Yusuf
Summary: In this study, nano-carbonated hydroxyapatite (n-CHAp) was successfully synthesized using abalone shells as the calcium source with different aging times to obtain B-type CHAp samples, which have potential applications in bone tissue engineering.
NANOMATERIALS AND NANOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Mona Sari, Yusril Yusuf
INTERNATIONAL JOURNAL OF NANOELECTRONICS AND MATERIALS
(2018)
Article
Materials Science, Biomaterials
Christopher Igwe Idumah, I. C. Nwuzor, S. R. Odera, U. J. Timothy, U. Ngenegbo, F. A. Tanjung
Summary: This paper presents recent advancements in drug delivery applications of polymeric hydrogel nanoarchitectures and hydrogel derivatives, including the incorporation of nanoparticulates and the enhancement of the chemical, biological, electrical, and mechanical properties of hydrogels. The application of magnetically responsive and smart hydrogels as drug delivery systems is also discussed.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2024)
Article
Materials Science, Biomaterials
Remya K. Rajan, Sunitha Chandran, Annie John, Ramesh Parameswaran
Summary: This study outlines the fabrication and characterization of pamidronate (PDS) embedded nanofibrous scaffolds based on polycaprolactone/polycaprolactone-polyethyleneglycol-polycaprolactone (PCL/CEC) blends for osteoporotic bone defect management. The electrospinning technique was utilized to fabricate PDS-loaded scaffolds, and the effect of PDS on the blends was evaluated in terms of surface morphology, wettability, biodegradability, and in vitro cytocompatibility. The results showed that the PCL/CEC-PDS scaffolds had a fibroporous architecture, appropriate mechanical properties, and the ability to support cell growth, indicating their potential for managing osteoporotic bone defects.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2024)
Article
Materials Science, Biomaterials
Kubra Aydin, Handan Sevim, Hatice Kaplan Can
Summary: This study aims to develop a new dental material by designing, synthesizing, and characterizing nanocomposites, and evaluate their cytotoxic effects on human gingival fibroblasts. The results of this research will contribute to a better understanding of the properties and safety of this material, providing reference for clinical applications in dentistry.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2024)
Review
Materials Science, Biomaterials
Angelica Jimenez-Rosales, Stefani Cortes-Camargo, Pedro Estanislao Acuna-Avila
Summary: The immune response to drug-delivering systems and implanted medical devices based on biomaterials is complex, and the goal is to design biomaterials that can respond to stimuli, preserve tissue function, and optimize cellular structures. Understanding the material's structure and location, as well as the severity of damage and other factors, is crucial in developing biocompatible biomaterials.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2024)
Article
Materials Science, Biomaterials
Fatemeh Daliri Shadmehri, Ehsan Karimi, Ehsan Saburi
Summary: Bone tissue engineering utilizes polymeric scaffolds and stem cells to create a supportive matrix resembling the in vivo environment for bone repair. The study found that a composite matrix of polycaprolactone and fibrin enhanced the differentiation of adipose-derived stem cells into osteo-like cells.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2024)
