On the Dependence of Prion and Amyloid Structure on the Folding Environment

AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils

(2021) Akanksha Bansal et al.   Nature Communications

Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain

(2021) Nelson Ferreira et al.   Acta Neuropathologica Communications

Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential

(2021) Nelson Ferreira et al.   ACTA NEUROPATHOLOGICA

How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer’s Disease and Other Neurodegenerative Disorders

(2021) George A. Carlson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural Water Stabilizes Protein Motifs in Liquid Protein Phase: The Folding Mechanism of Short β-Sheets Coupled to Phase Transition

(2021) Dóra Papp et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High-resolution structure and strain comparison of infectious mammalian prions

(2021) Allison Kraus et al.   MOLECULAR CELL

In Silico Modeling of the Influence of Environment on Amyloid Folding Using FOD-M Model

(2021) Irena Roterman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core

(2020) Calina Glynn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Kinetic diversity of amyloid oligomers

(2020) Alexander J. Dear et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila

(2020) Ruben Hervas et al.   SCIENCE

Structure of the Hydrophobic Core Determines the 3D Protein Structure—Verification by Single Mutation Proteins

(2020) Mateusz Banach et al.   Biomolecules

The Structure of Amyloid Versus the Structure of Globular Proteins

(2020) Piotr Fabian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cryo-EM structure of an amyloid fibril formed by full-length human prion protein

(2020) Li-Qiang Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Downhill, Ultrafast and Fast Folding Proteins Revised

(2020) Mateusz Banach et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure

(2020) Yunpeng Sun et al.   Nature Communications

Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats

(2019) Nathalie Van Den Berge et al.   ACTA NEUROPATHOLOGICA

Structural characterization of POM6 Fab and mouse prion protein complex identifies key regions for prions conformational conversion

(2018) Pravas Kumar Baral et al.   FEBS Journal

Insights into the Molecular Mechanisms of Alzheimer’s and Parkinson’s Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology

(2018) Orkid Coskuner-Weber et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

(2018) Chao Peng et al.   NATURE

Structural basis for the complete resistance of the human prion protein mutant G127V to prion disease

(2018) Zhen Zheng et al.   Scientific Reports

Water Is a Cagey Liquid

(2018) Tomaz Urbic et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Application of the Fuzzy Oil Drop Model Describes Amyloid as a Ribbonlike Micelle

(2017) Irena Roterman et al.   Entropy

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

(2017) Giuliana Fusco et al.   SCIENCE

The Amyloid Phenomenon and Its Links with Human Disease

(2017) Christopher M. Dobson   Cold Spring Harbor Perspectives in Biology

A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration

(2016) Karen E. Marshall et al.   Scientific Reports

X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins

(2015) Pravas Kumar Baral et al.   JOURNAL OF STRUCTURAL BIOLOGY

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

Structure-based drug design identifies polythiophenes as antiprion compounds

(2015) Uli S. Herrmann et al.   Science Translational Medicine

Prions and Prion-like Proteins

(2014) Paul E. Fraser   JOURNAL OF BIOLOGICAL CHEMISTRY

Prions: Generation and SpreadVersusNeurotoxicity

(2014) Mark Halliday et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Prion Inhibition by Phenothiazine Compounds

(2014) Pravas Kumar Baral et al.   STRUCTURE

The amyloid-cell membrane system. The interplay between the biophysical features of oligomers/fibrils and cell membrane defines amyloid toxicity

(2013) Cristina Cecchi et al.   BIOPHYSICAL CHEMISTRY

N-Terminal Helix-Cap in α-Helix 2 Modulates β-State Misfolding in Rabbit and Hamster Prion Proteins

(2013) Braden Sweeting et al.   PLoS One

Simple Model of Hydrophobic Hydration

(2012) Miha Lukšič et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Protein-Folding Problem, 50 Years On

(2012) K. A. Dill et al.   SCIENCE

Mutational Tipping Points for Switching Protein Folds and Functions

(2012) Yanan He et al.   STRUCTURE

The Amyloid-Congo Red Interface at Atomic Resolution

(2011) Anne K. Schütz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Water in the orchestration of the cell machinery. Some misunderstandings: a short review

(2011) Pascale Mentré   JOURNAL OF BIOLOGICAL PHYSICS

Modeling aqueous solvation with semi-explicit assembly

(2011) C. J. Fennell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Interactions of Oligomeric Alpha-Synuclein: Potential Role in Parkinsons Disease

(2010) Bart D. van Rooijen et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Atomic-Resolution Three-Dimensional Structure of HET-s(218−289) Amyloid Fibrils by Solid-State NMR Spectroscopy

(2010) Hélène Van Melckebeke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid fibrils

(2010) Roma N. Rambaran et al.   Prion

On the entropy of protein folding

(2010) George I. Makhatadze et al.   PROTEIN SCIENCE

The Protein Folding Problem

(2008) Ken A. Dill et al.   Annual Review of Biophysics

Amyloid Fibrils of the HET-s(218-289) Prion Form a   Solenoid with a Triangular Hydrophobic Core

(2008) C. Wasmer et al.   SCIENCE