Distinct molecular phenotypes involving several human diseases are induced by IFN-λ3 and IFN-λ4 in monocyte-derived macrophages

Expression of Interferons Lambda 3 and 4 Induces Identical Response in Human Liver Cell Lines Depending Exclusively on Canonical Signaling

(2021) Mariia Lunova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IFN-λ4 is associated with increased risk and earlier occurrence of several common infections in African children

(2021) Ludmila Prokunina-Olsson et al.   GENES AND IMMUNITY

IFN-λ4 genetic variants influence clinical malaria episodes in a cohort of Kenyan children

(2021) Gabriela Samayoa-Reyes et al.   MALARIA JOURNAL

Interferon-λ3 Exacerbates the Inflammatory Response to Microbial Ligands: Implications for SARS-CoV-2 Pathogenesis

(2021) Scott A Read et al.   Journal of Inflammation Research

Functional genetic variants of the IFN-λ3 (IL28B) gene and transcription factor interactions on its promoter

(2021) Subhajit Roy et al.   CYTOKINE

Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses

(2021) Qian Chen et al.   Nature Communications

Intracellular Accumulation of IFN-λ4 Induces ER Stress and Results in Anti-Cirrhotic but Pro-HCV Effects

(2021) Olusegun O. Onabajo et al.   Frontiers in Immunology

Conserved Induction of Distinct Antiviral Signalling Kinetics by Primate Interferon Lambda 4 Proteins

(2021) Cuncai Guo et al.   Frontiers in Immunology

Age-Dependent Effects of Type I and Type III IFNs in the Pathogenesis of Bordetella pertussis Infection and Disease

(2020) Jeremy Ardanuy et al.   JOURNAL OF IMMUNOLOGY

Monocytes differentiated into macrophages and dendritic cells in the presence of human IFN‐λ3 or IFN‐λ4 show distinct phenotypes

(2020) Manjarika De et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interferon Lambda and Liver Fibrosis

(2019) Mohammed Eslam et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Genetics of the Human Interferon Lambda Region

(2019) Ludmila Prokunina-Olsson   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The Genetic Association of IFN-λs with Human Inflammatory Disorders Remains a Conundrum

(2019) Sreedhar Chinnaswamy et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The IFN-λ4 Conundrum: When a Good Interferon Goes Bad

(2019) Olusegun O. Onabajo et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Interferon lambda 4 impacts the genetic diversity of hepatitis C virus

(2019) M Azim Ansari et al.   eLife

Macrophage Coordination of the Interferon Lambda Immune Response

(2019) Scott A. Read et al.   Frontiers in Immunology

IFNL4-ΔG allele is associated with an interferon signature in tumors and survival of African-American men with prostate cancer

(2018) Wei Tang et al.   CLINICAL CANCER RESEARCH

Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance

(2018) Kalliopi Pervolaraki et al.   PLoS Pathogens

The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity

(2017) Juan L. Mendoza et al.   IMMUNITY

IFN-λ4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling

(2017) Adeola A. Obajemu et al.   JOURNAL OF IMMUNOLOGY

Confounding by Single Nucleotide Polymorphism rs117648444 (P70S) Affects the Association of Interferon Lambda Locus Variants with Response to Interferon-α-Ribavirin Therapy in Patients with Chronic Genotype 3 Hepatitis C Virus Infection

(2017) Anand Bhushan et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Interferon lambda 4 expression is suppressed by the host during viral infection

(2016) MeeAe Hong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcriptome analysis reveals a classical interferon signature induced by IFNλ4 in human primary cells

(2015) C Lauber et al.   GENES AND IMMUNITY

Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance

(2015) Thomas R. O’Brien et al.   JOURNAL OF HEPATOLOGY

Immunomodulatory Function of Interleukin 28B During Primary Infection With Cytomegalovirus

(2014) Adrian Egli et al.   JOURNAL OF INFECTIOUS DISEASES

Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 (IFNL4)

(2014) Felix M. Key et al.   PLoS Genetics

MTML-msBayes: Approximate Bayesian comparative phylogeographic inference from multiple taxa and multiple loci with rate heterogeneity

(2013) Wen Huang et al.   BMC BIOINFORMATICS

Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses

(2013) Ole J Hamming et al.   EMBO JOURNAL

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

(2013) Ludmila Prokunina-Olsson et al.   NATURE GENETICS

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Template-based protein structure modeling using the RaptorX web server

(2012) Morten Källberg et al.   Nature Protocols

Evolutionary genetic dissection of human interferons

(2011) Jérémy Manry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases

(2011) Chen Xie et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of Human Interferon-λ1 in Complex with Its High-Affinity Receptor Interferon-λR1

(2010) Zachary J. Miknis et al.   JOURNAL OF MOLECULAR BIOLOGY

Gene ontology analysis for RNA-seq: accounting for selection bias

(2010) Matthew D Young et al.   GENOME BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Interferon-λ Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family

(2009) Hans Henrik Gad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY