Article
Cell Biology
Yundi Zhang, Ke Zhang, Haoming Gong, Qin Li, Lajie Man, Qingchang Jin, Lin Zhang, Song Li
Summary: Our study reveals a close association between m(6)A modification and TME formation. Evaluating m(6)A in cancer helps us understand the TME status, and targeting m(6)A in tumor cells may help modulate the TME and improve tumor therapy and immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Chen Chen, Weitang Yuan, Quanbo Zhou, Bo Shao, Yuying Guo, Weiwei Wang, Shuaixi Yang, Yaxin Guo, Luyang Zhao, Qin Dang, Xiuxiu Yang, Guixian Wang, Qiaozhen Kang, Zhenyu Ji, Jinbo Liu, Zhenqiang Sun
Summary: A novel circRNA, circ1662, was found to be highly expressed in CRC tissues and correlated with poor prognosis and tumor depth. Functionally, circ1662 promoted CRC cell invasion and migration by controlling EMT and accelerating YAP1 nuclear accumulation to regulate the SMAD3 pathway.METTL3 induced circ1662 expression and played a role in CRC metastasis.
Article
Biochemistry & Molecular Biology
Junlong Zhu, Hang Tong, Yan Sun, Tinghao Li, Guang Yang, Weiyang He
Summary: N6-methyladenosine (m6A) is a common mRNA modification that plays a critical role in tumor progression, prognoses, and therapeutic response. This study focuses on the role of m6A modifications in bladder carcinogenesis and development and investigates the association between METTL3/YTHDF1 and bladder cancer cell proliferation and cisplatin resistance. The results show that reduced expression of METTL3/YTHDF1 leads to decreased bladder cancer cell proliferation and cisplatin sensitivity, while overexpression of the downstream target gene, RPN2, can rescue this effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Ying Li, Liang He, Yingkai Wang, Yan Tan, Fan Zhang
Summary: The up-regulation of KIAA1429 is closely related to the poor prognosis of CRC patients. KIAA1429 promotes aerobic glycolysis in CRC and positively up-regulates HK2 level by increasing its mRNA stability.
Article
Multidisciplinary Sciences
Juan Wang, Lei Wang, Xingfeng Tian, Lingping Luo
Summary: Asthma is a chronic respiratory disease with multiple pathologic molecular mechanisms, presenting a challenge to clinic nursing. Emerging evidence suggests that m6A plays critical roles in respiratory system disease. This study investigated the functions of m6A reader YTHDF1 in asthma and identified a novel axis of YTHDF1/m6A/cyclin D1 in airway remodeling, providing a potential therapeutic strategy.
Article
Biochemistry & Molecular Biology
Xin Zong, Xiao Xiao, Bin Shen, Qin Jiang, Hong Wang, Zeqing Lu, Fengqin Wang, Mingliang Jin, Junxia Min, Fudi Wang, Yizhen Wang
Summary: Recent evidence has shown that the N-6-methyladenosine (m(6)A) mRNA modification is closely associated with innate immunity, with the YTH domain-containing protein YTHDF1 playing a key role in regulating the immune response against bacterial pathogens in the intestine. Through interactions between the P/Q/N-rich domain in YTHDF1 and the DEAD domain in the host factor DDX60, YTHDF1 is involved in recognizing and regulating the immune response to bacterial infection in the intestines.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Huarong Chen, Shanshan Gao, Weixin Liu, Chi-Chun Wong, Jianfeng Wu, Jingtong Wu, Dabin Liu, Hongyan Gou, Wei Kang, Jianning Zhai, Chuangen Li, Hao Su, Shiyan Wang, Fraser Soares, Jiahuai Han, Housheng Hansen He, Jun Yu
Summary: The study revealed that the m(6)A regulatory enzyme METTL3 is upregulated in colorectal cancer (CRC) and predicts poor survival in patients. Inhibition of METTL3 suppresses tumorigenesis in CRC cells and organoids. METTL3 promotes CRC development by activating the m(6)A-GLUT1-mTORC1 axis.
Article
Agriculture, Dairy & Animal Science
Huanfa Gong, Tao Gong, Youhua Liu, Yizhen Wang, Xinxia Wang
Summary: In this research, m(6)A sequencing was used to discover genes that showed differential RNA expression and m(6)A modification between high and low IMF groups. ADIPOQ and SFRP1 were identified as hub genes through gene co-expression analysis. ADIPOQ, which contains m(6)A modification sites, was found to promote porcine intramuscular preadipocyte differentiation in an m(6)A-dependent manner, with YT521-B homology domain family protein 1 (YTHDF1) targeting and promoting ADIPOQ mRNA translation.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Cell Biology
Hao Wang, Wei Wei, Zhong-Yuan Zhang, Yao Liu, Bin Shi, Wen Zhong, Hou-Shun Zhang, Xin Fang, Chun-Lei Sun, Jia-Bei Wang, Lian-Xin Liu
Summary: Metastasis in colorectal cancer (CRC) remains a major challenge, and dysregulation of N6-methyladenosine (m6A) is associated with this process. This study reveals that METTL14, a key component of m6A methylation, plays a role in inhibiting CRC metastasis by regulating the ARRDC4/ZEB1 signaling pathway. METTL14 regulates ARRDC4 mRNA stability through YHTDF2, and its protein expression is controlled by TCF4 and HuR. Clinical studies show that decreased METTL14 is associated with poor prognosis in CRC patients.
CELL DEATH & DISEASE
(2022)
Article
Genetics & Heredity
Wei Song, Jun Ren, Wenzheng Yuan, Rensheng Xiang, Yuhang Ge, Tao Fu
Summary: The study identified 29 m6A-modified lncRNAs as prognostic markers in CRC and established a signature for predicting patient outcomes. Two molecular clusters were identified with significant differences in clinicopathological features and prognosis. The signature showed good predictive performance and proved to be an independent prognostic indicator. Additionally, a prognostic model based on the signature was developed to enhance OS prediction for CRC patients.
Review
Biochemistry & Molecular Biology
Zhihao Fang, Yiqiu Hu, Jinhui Hu, Yanqin Huang, Shu Zheng, Cheng Guo
Summary: Recent studies have shown the association between changes in m(6)A levels and dysregulation of m(6)A regulatory proteins with CRC carcinogenesis and progression. Despite the unclear regulatory laws of m(6)A modification in CRC, a better understanding of these mechanisms could benefit the diagnosis and therapy of CRC.
CELL AND BIOSCIENCE
(2021)
Article
Immunology
Jinye Xie, Zhijian Huang, Ping Jiang, Runan Wu, Hongbo Jiang, Chuanghua Luo, Honghai Hong, Haofan Yin
Summary: The research reveals that m(6)A RNA levels in peripheral blood immune cells of colorectal cancer (CRC) patients were significantly elevated, serving as a potential non-invasive diagnostic biomarker and valuable therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Jingnan Pi, Wen Wang, Ming Ji, Xiaoshuang Wang, Xueju Wei, Jing Jin, Tao Liu, Jiaqi Qiang, Zhihong Qi, Feng Li, Yue Liu, Yanni Ma, Yanmin Si, Yue Huo, Yufeng Gao, Yiying Chen, Lei Dong, Rui Su, Jianjun Chen, Shuan Rao, Ping Yi, Shuyang Yu, Fang Wang, Jia Yu
Summary: This study reveals the oncogenic role of YTHDF1 in gastric cancer, showing its regulation of the Wnt/β-catenin signaling pathway through m(6)A modification. Inhibition of YTHDF1 can reduce gastric cancer cell proliferation and tumorigenesis, suggesting a new approach for targeting epigenetic regulators in cancer treatment.
Article
Oncology
Haocheng Wang, Qingya Luo, Jianyi Kang, Qinglv Wei, Yu Yang, Dan Yang, Xiaoyi Liu, Tao Liu, Ping Yi
Summary: The study demonstrated that YTHDF1 is highly expressed in cervical cancer and associated with poor prognosis, by regulating the expression of RANBP2 to exert its oncogenic role in cervical cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Microbiology
Hao Su, Henley Cheung, Harry Cheuk-Hay Lau, Hongyan Chen, Xiaoting Zhang, Na Qin, Yifei Wang, Matthew Tak Vai Chan, William Ka Kei Wu, Huarong Chen
Summary: Understanding the interaction between gut microbiota and host RNA m6A modification provides valuable insights into the mechanisms and therapeutic strategies for cancer. The gut microbiota plays a crucial role in regulating host functions and has a significant impact on human health. Dysbiosis of the gut microbiota is associated with various diseases including cancer. The gut microbiota can influence cancer development through mechanisms such as cell regulation, immune response, and metabolic changes. Aberrant RNA m6A modifications have been shown to play a critical role in cancer development. This review aims to summarize the roles of gut microbiota and RNA m6A modifications in cancer and their potential interactions.
FEMS MICROBIOLOGY REVIEWS
(2023)
Article
Oncology
Jinglin Zhang, Bonan Chen, Hui Li, Yifei Wang, Xiaoli Liu, Kit Yee Wong, Wai Nok Chan, Aden K. Y. Chan, Alvin H. k Cheung, Kam Tong Leung, Yujuan Dong, Yi Pan, Huixing Ke, Li Liang, Zhaocai Zhou, Jianyong Xiao, Chi Chun Wong, William K. K. Wu, Alfred S. L. Cheng, Brigette B. Y. Ma, Jun Yu, Kwok Wai Lo, Wei Kang, Ka Fai To
Summary: Colorectal cancer (CRC) is a common cancer worldwide, and the tumor microenvironment, specifically cancer-associated fibroblasts (CAFs), plays a crucial role in promoting CRC progression.
JOURNAL OF PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Feiyu Shi, Gaixia Liu, Yufeng Lin, Cosmos Liutao Guo, Jing Han, Eagle S. H. Chu, Chengxin Shi, Yaguang Li, Haowei Zhang, Chenhao Hu, Ruihan Liu, Shuixiang He, Gang Guo, Yinnan Chen, Xiang Zhang, Olabisi Oluwabukola Coker, Sunny Hei Wong, Jun Yu, Junjun She
Summary: Appendectomy is associated with an increased risk of colorectal cancer (CRC) due to gut microbial dysbiosis. A longitudinal study (cohort 1, n = 129,155) showed a 73.0% increase in CRC risk among appendectomy cases during a 20-year follow-up period. Fecal samples from another cohort (n = 314) revealed dysbiosis in the gut microbiome of appendectomy subjects, with enrichment of CRC-promoting bacteria and depletion of beneficial commensals. Microbial network analysis indicated stronger correlations and enriched oncogenic pathways among bacteria in appendectomy subjects compared to controls. Appendectomy was also found to promote colorectal tumorigenesis in mice through microbial dysbiosis and impaired intestinal barrier function. This study highlights the importance of the gut microbiome in CRC development following appendectomy.
Article
Engineering, Electrical & Electronic
Guolin Yang, Xingliang Jiang, Jianlin Hu, Xiaodong Ren, Tao Li, Jianguo Wu, Zhijin Zhang, Qin Hu, Hualong Zheng
Summary: This study investigates the effects of particle concentration, particle size, and particle dielectric constant on the DC breakdown characteristics of unclean air gap. It is found that the presence of solid particles increases the breakdown voltage of the gap, with the increase being related to the particle concentration, size, and dielectric constant. Additionally, the presence of particles enhances both the ionization process and particle adsorption, leading to an increase in the gap breakdown voltage.
Article
Oncology
Zhenjie Yang, Shanshan Gao, Chi Chun Wong, Weixin Liu, Huarong Chen, Haiyun Shang, Zoe Yuet Wu, Lixia Xu, Xiang Zhang, Nathalie Wong, Ming Kuang, Jun Yu
Summary: Non-alcoholic fatty liver disease-associated hepatocellular carcinoma (NAFLD-HCC) is a growing malignancy with no available targeted therapy. This study identified TUBB4B as an essential gene for NAFLD-HCC cell growth and demonstrated that its inhibition with mebendazole (MBZ) in combination with navitoclax synergistically inhibited NAFLD-HCC growth by inducing apoptosis and cellular senescence. These findings suggest TUBB4B as a novel therapeutic target for NAFLD-HCC.
JOURNAL OF PATHOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yifei Wang, Huarong Chen
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths globally. Protein glycosylation, a common post-translational modification, plays a crucial role in regulating various biological processes and is implicated in the development of HCC. Aberrant protein glycosylation in hepatocytes contributes to the malignant transformation to HCC by modulating tumor-promoting signaling pathways. Changes in protein glycosylation could serve as potential diagnostic, prognostic, and therapeutic factors in HCC.
Article
Multidisciplinary Sciences
Zhao Wei, Song Wang, Yaning Xu, Wenzheng Wang, Fraser Soares, Musaddeque Ahmed, Ping Su, Tingting Wang, Elias Orouji, Xin Xu, Yong Zeng, Sujun Chen, Xiaoyu Liu, Tianwei Jia, Zhaojian Liu, Lutao Du, Yunshan Wang, Shaoyong Chen, Chuanxin Wang, Housheng Hansen He, Haiyang Guo
Summary: This study reveals that MYC interacts with CTCF protein and rewires the chromatin architecture in prostate cancer by modifying CTCF-mediated chromatin looping. MYC colocalizes with CTCF at certain genomic sites, enhancing CTCF occupancy and promoting CTCF-mediated chromatin looping, which disrupts the enhancer-promoter loops of genes related to neuroendocrine lineage plasticity.
NATURE COMMUNICATIONS
(2023)
Article
Thermodynamics
Alejandro Gallegos, Jianzhong Wu
Summary: The study aims to develop a predictive model for describing the electrostatic behavior of amino acids in aqueous solutions. A three-bead coarse-grained model is proposed, and a thermodynamic model accounting for nonideality effects is developed to capture how the interaction varies with solution conditions.
JOURNAL OF CHEMICAL AND ENGINEERING DATA
(2023)
Article
Engineering, Civil
Guanghui Zhao, Dongqi Wang, Taihu Sun, Yan Ding, Shu Chen, Yizhe Li, Hechen Sun, Chenyang Wu, Zhongjie Yu, Zhenlou Chen
Summary: Urban rivers are significant hotspots for greenhouse gas (GHG) emissions. This study investigated the impact of different rainfall events on GHG emissions from Suzhou Creek in Shanghai. It was found that typhoon events significantly increased GHG emissions, with factors such as rainfall dilution, pump station drainage, sediment disturbance, and high gas transfer coefficient playing important roles. The study highlights the importance of understanding the dynamic response of urban river GHG emissions to rainfall and typhoons.
JOURNAL OF HYDROLOGY
(2023)
Article
Chemistry, Physical
Debadutta Prusty, Alejandro Gallegos, Jianzhong Wu
Summary: The interfacial behavior of associating species is crucial for both fundamental physics and industrial applications. This study investigates the adsorption behavior of a mixture of nanoparticles and polymer chains, representing asphaltene and resin molecules, onto an attractive surface. The results provide insights into the effects of various characteristics of these molecules on the adsorption amount and reveal the interplay between different driving forces.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Materials Science, Coatings & Films
Yinchun Fang, Jianguo Wu, Shuo Chang, Lingshuang Wu
Summary: This study used bio-based phytic acid (PA) and gelatine (G) to improve the flame retardancy and anti-dripping properties of polyethylene terephthalate (PET) fabric. The coated PET fabric showed a limiting oxygen index (LOI) value greater than 29.5% and no dripping phenomenon, indicating significant improvement in flame retardancy and anti-dripping properties. The PA/G coating altered the decomposition stability and degradation process of PET fabric, promoting the formation of a stable char. The coating formed an intumescent flame retardant (IFR) system on PET fabric, functioning through the IFR mechanism.
SURFACE ENGINEERING
(2023)
Article
Virology
Weijie Chen, Yukun Li, Xiuling Yu, Zhenwei Wang, Wenbiao Wang, Menglan Rao, Yongkui Li, Zhen Luo, Qiwei Zhang, Jinbiao Liu, Jianguo Wu
Summary: In this study, it was found that Zika virus infection upregulated 7-dehydrocholesterol reductase (DHCR7) expression, which in turn facilitated viral infection. The nonstructural protein NS4B of Zika virus interacted with DHCR7 to induce its expression, thereby inhibiting the immune response and facilitating viral evasion. This study expands our understanding of the mechanisms by which viral nonstructural proteins antagonize innate immunity during viral infection via cholesterol metabolic enzymes and intermediates.
Article
Automation & Control Systems
Zhiyong Hu, Chao Wang, Jianguo Wu, Dongping Du
Summary: The development of sensor technologies has allowed the acquisition of high dimensional sensing data, which has led to the development of multi-output modeling techniques for decision making. However, missing values in the data often result in information loss and affect the modeling performance. This study proposes a new multi-output modeling method based on GPLVM to exploit useful information in the data and improve modeling accuracy. The method demonstrates superior performance in both simulation and case studies, making it a powerful tool for process automation.
IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Yang Lyu, Fuda Xie, Bonan Chen, Wing Sum Shin, Wei Chen, Yulong He, Kam Tong Leung, Gary M. K. Tse, Jun Yu, Ka Fai To, Wei Kang
Summary: This review focuses on the complex interaction between the nervous system and gastrointestinal (GI) cancer, exploring the mechanisms of GI cancer development. It discusses the intricate relationship between the nervous system and GI tract development and tumor progression, as well as the feedback regulation of tumor cells on the nervous system. The review also highlights the influence of various components within the tumor microenvironment on GI cancer occurrence and progression. Furthermore, it emphasizes the transformation relationship between non-neuronal cells and neuronal cells, inspiring the development of nervous system-guided anti-tumor drugs.
Review
Biochemistry & Molecular Biology
Hui Chen, Cheng Jin, Li Xie, Jian Wu
Summary: Succinate, an intermediate of the TCA cycle, is crucial in mitochondrial metabolism, energy production, and is also considered a signaling molecule in metabolism and hepatic diseases. Its downstream signaling pathway through GPR91 leads to various intracellular responses, including succinylation, ROS production, HIF-1 alpha stabilization, and significant impact in cellular metabolism due to its role in the TCA cycle. Understanding the signaling mechanisms of succinate in hepatic fibrosis, metabolic reprogramming, inflammatory or immune responses, and carcinogenesis is of great interest. This review aims to provide the current understanding of succinate in mediating metabolism, inflammatory and immune responses in liver diseases, with the aim of establishing a molecular basis for therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Letter
Surgery
Sami Shoucair, Jun Yu
