Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response

Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

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Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis

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Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

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Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

(2017) Ahmet Zehir et al.   NATURE MEDICINE

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

(2017) Jarno Drost et al.   SCIENCE

Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer

(2017) Yelena Y. Janjigian et al.   Cancer Discovery

Recurrent SERPINB3 and SERPINB4 mutations in patients who respond to anti-CTLA4 immunotherapy

(2016) Nadeem Riaz et al.   NATURE GENETICS

Classification and characterization of microsatellite instability across 18 cancer types

(2016) Ronald J Hause et al.   NATURE MEDICINE

Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity

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Differential DNA mismatch repair underlies mutation rate variation across the human genome

(2015) Fran Supek et al.   NATURE

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

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Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

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Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

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Microsatellite Instability Detection by Next Generation Sequencing

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Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

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MSIsensor: microsatellite instability detection using paired tumor-normal sequence data

(2013) Beifang Niu et al.   BIOINFORMATICS

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes

(2013) Tae-Min Kim et al.   CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Inferring tumour purity and stromal and immune cell admixture from expression data

(2013) Kosuke Yoshihara et al.   Nature Communications

Molecular Classification and Correlates in Colorectal Cancer

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