Skeletal muscle mitochondrial respiration in a model of age-related osteoarthritis is impaired after dietary rapamycin

Correction for: Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance

(2020) Lan Ye et al.   Aging-US

mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging

(2019) Candice E. Van Skike et al.   AGING CELL

Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging

(2018) Marta Gonzalez-Freire et al.   AGING CELL

High Fat Diet Causes Mitochondrial Dysfunction as a Result of Impaired ADP Sensitivity

(2018) Paula M Miotto et al.   DIABETES

Alterations in quadriceps muscle cellular and molecular properties in adults with moderate knee osteoarthritis

(2018) B. Noehren et al.   OSTEOARTHRITIS AND CARTILAGE

Age-Associated Impairments in Mitochondrial ADP Sensitivity Contribute to Redox Stress in Senescent Human Skeletal Muscle

(2018) Graham P. Holloway et al.   Cell Reports

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults

(2018) Adam R. Konopka et al.   AGING CELL

Skeletal muscle mitochondrial protein synthesis and respiration in response to the energetic stress of an ultra-endurance race

(2017) Adam R. Konopka et al.   JOURNAL OF APPLIED PHYSIOLOGY

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

(2016) Randy Strong et al.   AGING CELL

Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice

(2016) Sebastian I. Arriola Apelo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

(2015) Sebastian I. Arriola Apelo et al.   AGING CELL

Men with Early Degrees of Knee Osteoarthritis Present Functional and Morphological Impairments of the Quadriceps Femoris Muscle

(2015) Paula Regina M.S. Serrão et al.   AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION

Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments

(2015) Pabalu P. Karunadharma et al.   FASEB JOURNAL

Knee extensor muscle weakness is a risk factor for development of knee osteoarthritis. A systematic review and meta-analysis

(2015) B.E. Øiestad et al.   OSTEOARTHRITIS AND CARTILAGE

Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart

(2014) Dao-Fu Dai et al.   AGING CELL

Skeletal Muscle Mitochondrial Function and Fatigability in Older Adults

(2014) Adam J. Santanasto et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The individual and socioeconomic impact of osteoarthritis

(2014) David J. Hunter et al.   Nature Reviews Rheumatology

Metformin Impairs Mitochondrial Function in Skeletal Muscle of Both Lean and Diabetic Rats in a Dose-Dependent Manner

(2014) Bart Wessels et al.   PLoS One

The State of US Health, 1990-2010

(2013) Christopher J. L. Murray   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Metformin Increases Mitochondrial Energy Formation in L6 Muscle Cell Cultures

(2013) Veeravenkata S. Vytla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assessment of Mitochondrial Biogenesis and mTORC1 Signaling During Chronic Rapamycin Feeding in Male and Female Mice

(2013) Joshua C. Drake et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Quadriceps intramuscular fat fraction rather than muscle size is associated with knee osteoarthritis

(2013) D. Kumar et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Skeletal Muscle Mitochondrial Energetics Are Associated With Maximal Aerobic Capacity and Walking Speed in Older Adults

(2012) Paul M. Coen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Is Quadriceps Muscle Weakness a Risk Factor for Incident or Progressive Knee Osteoarthritis?

(2012) Neil A. Segal et al.   PHYSICIAN AND SPORTSMEDICINE

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle

(2011) Christopher G. R. Perry et al.   BIOCHEMICAL JOURNAL

Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration

(2011) S. Larsen et al.   DIABETOLOGIA

Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats

(2010) Daniel A. Kane et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the guinea pig

(2010) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

Aberrant Mitochondrial Homeostasis in the Skeletal Muscle of Sedentary Older Adults

(2010) Adeel Safdar et al.   PLoS One

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Direct control of mitochondrial function by mTOR

(2009) Arvind Ramanathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA