A first-in-class anticancer dual HDAC2/FAK inhibitors bearing hydroxamates/benzamides capped by pyridinyl-1,2,4-triazoles

Discovery of antiproliferative and anti-FAK inhibitory activity of 1,2,4-triazole derivatives containing acetamido carboxylic acid skeleton

(2021) Muhamad Mustafa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and biological evaluation of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent Kinase2 (CDK2) dual inhibitors against malignant cancer

(2020) Fan Yun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Progress in the Development of Small Molecular Inhibitors of Focal Adhesion Kinase (FAK)

(2020) Yang Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent progress on HDAC inhibitors with dual targeting capabilities for cancer treatment

(2020) Xiaopeng Peng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study

(2019) Muhamad Mustafa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The histone deacetylases HDAC1 and HDAC2 are required for the growth and survival of renal carcinoma cells

(2018) Nicole Kiweler et al.   ARCHIVES OF TOXICOLOGY

Spirohydantoins and 1,2,4-triazole-3-carboxamide derivatives as inhibitors of histone deacetylase: Design, synthesis, and biological evaluation

(2018) Alshimaa M.A. Aboeldahab et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chimeric HDAC inhibitors: Comprehensive review on the HDAC-based strategies developed to combat cancer

(2018) Heba M. Hesham et al.   MEDICINAL RESEARCH REVIEWS

HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors

(2018) Rekha Sangwan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of the First-in-Class Dual Histone Deacetylase–Proteasome Inhibitor

(2018) Sanil Bhatia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Artesunate may inhibit liver fibrosis via the FAK/Akt/β-catenin pathway in LX-2 cells

(2018) Jian Lv et al.   BMC Pharmacology & Toxicology

Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1,2,4-triazoles as potential combretastatin analogues

(2017) Muhamad Mustafa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

HDAC2 promotes the migration and invasion of non-small cell lung cancer cells via upregulation of fibronectin

(2016) Li Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Dissecting structure–activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation

(2016) Balaram Ghosh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3

(2016) Nishant P. Visavadiya et al.   Cell Communication and Signaling

Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy

(2016) Jiachen Wen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Sustained Akt Activity Is Required to Maintain Cell Viability in Seborrheic Keratosis, a Benign Epithelial Tumor

(2016) Victor A. Neel et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)

(2016) Gregory R. Ott et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting FAK scaffold functions inhibits human renal cell carcinoma growth

(2015) Claire Béraud et al.   INTERNATIONAL JOURNAL OF CANCER

HDAC1 and HDAC2 independently predict mortality in hepatocellular carcinoma by a competing risk regression model in a Southeast Asian population

(2015) SER YENG LER et al.   ONCOLOGY REPORTS

Inhibition of focal adhesion kinase induces apoptosis in bladder cancer cells via Src and the phosphatidylinositol 3-kinase/Akt pathway

(2015) DEBO KONG et al.   Experimental and Therapeutic Medicine

Identification of a Novel Aminotetralin Class of HDAC6 and HDAC8 Selective Inhibitors

(2014) Guozhi Tang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Polypharmacology: Challenges and Opportunities in Drug Discovery

(2014) Andrew Anighoro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression

(2013) Matthew P Keasey et al.   Cell Communication and Signaling

1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities

(2013) Gamal El-Din A.A. Abuo-Rahma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

(2013) Benjamin E. L. Lauffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC Up-Regulation in Early Colon Field Carcinogenesis Is Involved in Cell Tumorigenicity through Regulation of Chromatin Structure

(2013) Yolanda Stypula-Cyrus et al.   PLoS One

Synthesis, molecular modeling, and biological evaluation of 1,2,4-triazole derivatives containing pyridine as potential anti-tumor agents

(2012) Yan-Bin Zhang et al.   MEDICINAL CHEMISTRY RESEARCH

The effect of combined treatment with cisplatin and histone deacetylase inhibitors on HeLa cells

(2011) Ke Long Jin et al.   Journal of Gynecologic Oncology

Aberrant Regulation of HDAC2 Mediates Proliferation of Hepatocellular Carcinoma Cells by Deregulating Expression of G1/S Cell Cycle Proteins

(2011) Ji Heon Noh et al.   PLoS One

Histone Deacetylase (HDAC) 1 and 2 Expression and Chemotherapy in Gastric Cancer

(2010) Kathrin Mutze et al.   ANNALS OF SURGICAL ONCOLOGY

Caspase-8 Association with the Focal Adhesion Complex Promotes Tumor Cell Migration and Metastasis

(2009) S. Barbero et al.   CANCER RESEARCH

Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer

(2008) Florian R Fritzsche et al.   BMC CANCER

Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy

(2008) W Weichert et al.   BRITISH JOURNAL OF CANCER

Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation

(2008) Daniel Lietha et al.   PLoS One