Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy

标题
Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy
作者
关键词
Histone deacetylase inhibitor, Thiol, Disulfide, Prodrug, Anti-tumor, Structure-activity relationship
出版物
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 109, Issue -, Pages 350-359
出版商
Elsevier BV
发表日期
2016-01-13
DOI
10.1016/j.ejmech.2016.01.013

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