Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives
出版年份 2021 全文链接
标题
Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives
作者
关键词
CYP51, Azole antifungals, Metabolic stability, Dihydrooxazole derivatives
出版物
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 224, Issue -, Pages 113715
出版商
Elsevier BV
发表日期
2021-07-22
DOI
10.1016/j.ejmech.2021.113715
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents
- (2019) Liyu Zhao et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Combating fluconazole-resistant fungi with novel β-azole-phenylacetone derivatives
- (2019) Liyu Zhao et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy
- (2017) Saeed Emami et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Structural analyses ofCandida albicanssterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis
- (2017) Tatiana Y. Hargrove et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Antifungal drug testing by combining minimal inhibitory concentration testing with target identification by gas chromatography–mass spectrometry
- (2017) Christoph Müller et al. Nature Protocols
- Design, synthesis, and biological evaluation of amide imidazole derivatives as novel metabolic enzyme CYP26A1 inhibitors
- (2015) Bin Sun et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Azole antifungals: 35 years of invasive fungal infection management
- (2015) David Allen et al. Expert Review of Anti-Infective Therapy
- Impact of Treatment Strategy on Outcomes in Patients with Candidemia and Other Forms of Invasive Candidiasis: A Patient-Level Quantitative Review of Randomized Trials
- (2012) D. R. Andes et al. CLINICAL INFECTIOUS DISEASES
- New developments in invasive fungal disease
- (2012) Andreas H Groll et al. Future Microbiology
- Correction: Comparison and Temporal Trends of Three Groups with Cryptococcosis: HIV-Infected, Solid Organ Transplant, and HIV-Negative/Non-Transplant
- (2012) Emily W. Bratton et al. PLoS One
- Hidden Killers: Human Fungal Infections
- (2012) G. D. Brown et al. Science Translational Medicine
- Design, Synthesis, and in vitro Antifungal Activity of 1-[(4-Substituted-benzyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols
- (2011) Rémi Guillon et al. ChemMedChem
- Review of Fluconazole Properties and Analytical Methods for Its Determination
- (2011) Josilene Chaves Ruela Corrêa et al. CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
- Antifungals to treatCandida albicans
- (2010) Varsha Moudgal et al. EXPERT OPINION ON PHARMACOTHERAPY
- Utilization of the Suzuki Coupling to Enhance the Antituberculosis Activity of Aryloxazoles
- (2010) Marvin J. Miller et al. HETEROCYCLES
- Enantioselective Formation oftert-Alkylamines by Desymmetrization of 2-Substituted Serinols
- (2008) Mi Sook Hong et al. CHEMISTRY-A EUROPEAN JOURNAL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started