Non-carbohydrate strategies to inhibit lectin proteins with special emphasis on galectins

An updated patent review of galectin-1 and galectin-3 inhibitors and their potential therapeutic applications (2016–present)

(2021) Aaftaab Sethi et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Serum galectins as potential biomarkers of inflammatory bowel diseases

(2020) Tony B. Yu et al.   PLoS One

Synthesis, 18F-radiolabeling and apoptosis inducing studies of novel 4, 7-disubstituted coumarins

(2020) Nerella Sridhar Goud et al.   BIOORGANIC CHEMISTRY

Construction of a Stapled α-Helix Peptide Library Displayed on Phage for the Screening of Galectin-3-Binding Peptide Ligands

(2020) Teerapat Anananuchatkul et al.   ACS Omega

Quinoline-Pyrazole Scaffold as a Novel Ligand of Galectin-3 and Suppressor of TREM2 Signaling

(2020) Moustafa Gabr et al.   ACS Medicinal Chemistry Letters

Novel benzimidazole-triazole hybrids as apoptosis inducing agents in lung cancer: Design, synthesis, 18F-radiolabeling & galectin-1 inhibition studies

(2020) Nerella Sridhar Goud et al.   BIOORGANIC CHEMISTRY

Studies on fragment-based design of allosteric inhibitors of human factor XIa

(2020) Rio S. Boothello et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Human Galectin-1 and its inhibitors: Privileged target for cancer and HIV

(2019) Narella Sridhar Goud et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Novel Heterocyclic Imines Linked Coumarin-Thiazole Hybrids as Anticancer Agents

(2019) Nerella Sridhar Goud et al.   Anti-Cancer Agents in Medicinal Chemistry

Synthesis of 1-benzyl-1H-benzimidazoles as galectin-1 mediated anticancer agents

(2019) Nerella Sridhar Goud et al.   BIOORGANIC CHEMISTRY

Synthesis and Biological evaluation of morpholines linked coumarin‐triazole hybrids as anticancer agents

(2019) Nerella Sridhar Goud et al.   Chemical Biology & Drug Design

Allostery in C-type lectins

(2019) Bettina G Keller et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Lactulose as a novel template for anticancer drug development targeting galectins

(2018) Chandan Kishor et al.   Chemical Biology & Drug Design

CellFy: A Cell-Based Fragment Screen against C-Type Lectins

(2018) Jessica Schulze et al.   ACS Chemical Biology

Bergenin: a computationally proven promising scaffold for novel galectin-3 inhibitors

(2018) Ranga Srinath Jayakody et al.   JOURNAL OF MOLECULAR MODELING

Allosteric Inhibition of a Mammalian Lectin

(2018) Jonas Aretz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Novel Galectin-1 Inhibitor Discovered through One-Bead Two-Compound Library Potentiates the Antitumor Effects of Paclitaxel in vivo

(2017) Tsung-Chieh Shih et al.   MOLECULAR CANCER THERAPEUTICS

Galectin-1 inhibitors and their potential therapeutic applications: a patent review

(2016) Helen Blanchard et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Design, Synthesis, and Biological Evaluation of Ring-Constrained Novobiocin Analogues as Hsp90 C-Terminal Inhibitors

(2014) Gaurav Garg et al.   ACS Medicinal Chemistry Letters

Nanomolar E-Selectin Antagonists with Prolonged Half-Lives by a Fragment-Based Approach

(2013) Jonas Egger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novobiocin analogues with second-generation noviose surrogates

(2012) Huiping Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antitumor Agent Calixarene 0118 Targets Human Galectin-1 as an Allosteric Inhibitor of Carbohydrate Binding

(2012) Ruud P. M. Dings et al.   JOURNAL OF MEDICINAL CHEMISTRY

Engineering an Antibiotic to Fight Cancer: Optimization of the Novobiocin Scaffold to Produce Anti-proliferative Agents

(2011) Huiping Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Burn control, an adipocyte-specific function for galectin-12

(2011) L. G. Baum   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quinoxalinoneinhibitors of the lectin DC-SIGN

(2011) Shane L. Mangold et al.   Chemical Science

A glycobiology review: Carbohydrates, lectins and implications in cancer therapeutics

(2010) Haike Ghazarian et al.   ACTA HISTOCHEMICA

Synthesis and Evaluation of Noviose Replacements on Novobiocin That Manifest Antiproliferative Activity

(2010) Huiping Zhao et al.   ACS Medicinal Chemistry Letters

C-type lectins and phagocytosis

(2009) Ann M. Kerrigan et al.   IMMUNOBIOLOGY

From carbohydrate leads to glycomimetic drugs

(2009) Beat Ernst et al.   NATURE REVIEWS DRUG DISCOVERY

Interfering with the Sugar Code: Design and Synthesis of Oligosaccharide Mimics

(2008) Anna Bernardi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Galectins: structure, function and therapeutic potential

(2008) Ri-Yao Yang et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Analogs of Tetrahydroisoquinoline Natural Products That Inhibit Cell Migration and Target Galectin-3 Outside of Its Carbohydrate-binding Site

(2008) Alem W. Kahsai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY