期刊
IMMUNOBIOLOGY
卷 214, 期 7, 页码 562-575出版社
ELSEVIER GMBH
DOI: 10.1016/j.imbio.2008.11.003
关键词
Collectin; DC-SIGN; Dectin-1; Mannose receptor; Pattern recognition receptor
类别
资金
- Wellcome Trust
- Medical Research Council (SA)
- National Research Foundation (SA)
- CANSA Research South Africa
- National Institutes of Health (USA)
To recognise and respond to pathogens, germ-line encoded pattern recognition receptors (PRRs) bind to conserved microbial structures and activate host defence systems, including microbial uptake by phagocytosis. Phagocytosis is a complex process that is instrumental in the control of extracellular pathogens, and this activity is mediated by several PRRs, including a number of C-type lectins. While some of these receptors have clearly been shown to mediate or regulate the uptake of pathogens, others are more contentious and are less well understood in terms of their phagocytic potential. Furthermore, very little is known about the underlying phagocytic mechanisms. Here, we review the phagocytic roles of the mannose receptor, Dectin-1, dendritic cell-specific ICAM grabbing non-integrin (DC-SIGN), DCL-1, mannose binding lectin and surfactant proteins A and D. (C) 2008 Elsevier GmbH. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据