Article
Oncology
Amelie Boichard, Scott M. Lippman, Razelle Kurzrock
Summary: The study found that high-level gene amplifications may not necessarily lead to overexpression at the RNA level, and non-focal amplifications are more likely to be silenced. If non-focal amplifications do result in overexpression, they may have therapeutic potential. Silencing specific high-level focal or non-focal gene amplifications could explain resistance to targeted drugs.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Gerda Kildisiute, Waleed M. Kholosy, Matthew D. Young, Kenny Roberts, Rasa Elmentaite, Sander R. van Hooff, Clarissa N. Pacyna, Eleonora Khabirova, Alice Piapi, Christine Thevanesan, Eva Bugallo-Blanco, Christina Burke, Lira Mamanova, Kaylee M. Keller, Karin P. S. Langenberg-Ververgaert, Philip Lijnzaad, Thanasis Margaritis, Frank C. P. Holstege, Michelle L. Tas, Marc H. W. A. Wijnen, Max M. van Noesel, Ignacio Del Valle, Giuseppe Barone, Reinier van der Linden, Catriona Duncan, John Anderson, John C. Achermann, Muzlifah Haniffa, Sarah A. Teichmann, Dyanne Rampling, Neil J. Sebire, Xiaoling He, Ronald R. de Krijger, Roger A. Barker, Kerstin B. Meyer, Omer Bayraktar, Karin Straathof, Jan J. Molenaar, Sam Behjati
Summary: The neuroblastoma cancer cells resemble fetal sympathoblasts, indicating a pan-neuroblastoma cancer cell state that could potentially be targeted for novel treatment strategies. The findings highlight the importance of understanding the phenotype of neuroblastoma cells for the development of immunotherapeutic and targeted avenues.
Article
Oncology
Chun-Mei Ji, Xu Zhang, Wentong Fang, Ling Meng, Xiaolong Wei, Chen Lu
Summary: RNPC1 acts as an oncogene in gastric cancer by influencing cell mitosis through increasing AURKB mRNA stability, which may provide a potential biomarker and therapeutic target for gastric cancer.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Developmental Biology
Mansour Aboelenain, Karen Schindler
Summary: This study demonstrates that AURKB negatively regulates CPEB1-dependent translation through modulation of AURKA activity, which is crucial for generating euploid eggs.
Article
Medicine, Research & Experimental
Zhuo-Xun Wu, Qiuyan Mai, Yuqi Yang, Jing-Quan Wang, Hansu Ma, Leli Zeng, Zhe-Sheng Chen, Yihang Pan
Summary: Overexpression of ABCG2 transporter leads to resistance of cancer cells to GSK1070916, and combination with an ABCG2 inhibitor can restore the sensitivity of GSK1070916.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Antal H. Kovacs, Dong Zhao, Jinqiang Hou
Summary: This paper presents a comprehensive review of the preclinical and clinical candidates of Aurora B inhibitors as potential anticancer drugs. The recent advances in the field of Aurora B inhibitor development will be highlighted, and the binding interactions between Aurora B and inhibitors based on crystal structures will be presented and discussed to provide insights for the future design of more selective Aurora B inhibitors.
Article
Oncology
Justin F. Bejar, Zachary DiSanza, Suzanne M. Quartuccio
Summary: Overexpression of AURKC in cancer cells may play an oncogenic role, and targeting it could potentially reduce cancer cell migration and disease progression. Experimental results show that cancer cells lacking AURKC have no change in cell proliferation, but exhibit decreased migration and colony formation in soft agar.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mohammad Jalalirad, Tufia C. Haddad, Jeffrey L. Salisbury, Derek Radisky, Minzhi Zhang, Mark Schroeder, Ann Tuma, Eduard Leof, Jodi M. Carter, Amy C. Degnim, Judy C. Boughey, Jann Sarkaria, Jia Yu, Liewei Wang, Minetta C. Liu, Luca Zammataro, Lorenzo Malatino, Evanthia Galanis, James N. Ingle, Matthew P. Goetz, Antonino B. D'Assoro
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer, with progression linked to the enrichment of breast tumor-initiating cells (BTICs) and chemoresistance. The study revealed that AURKA kinase plays a critical role in mediating TGF-beta-induced TNBC plasticity, chemoresistance, and tumor progression.
Review
Chemistry, Medicinal
Naga Rajiv Lakkaniga, Zhengyu Wang, Yao Xiao, Anupreet Kharbanda, Li Lan, Hong-yu Li
Summary: Aurora Kinase B, as a therapeutic target for cancer treatment, has been studied for more than two decades. Inhibitors of Aurora Kinase B show promising biological results in vitro and in vivo experiments. Although no approved inhibitors for clinical use are available due to associated side effects, they exhibit excellent synergy with other treatment methods, making them a potential adjuvant therapy for difficult-to-treat cancers.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Oncology
Maria Saigi, Enric Carcereny, Teresa Moran, Marc Cucurull, Ainhoa Hernandez, Eva Pros, Montse Sanchez-Cespedes, Marta Domenech, Anna Martinez-Cardus
Summary: Identifying molecular oncogenic drivers is crucial for precision oncology. Genetic rearrangements, including gene fusions and gene amplification, involving and activating receptor tyrosine kinases (RTKs) are recurrent in solid tumors, particularly in non-small cell lung cancer. Advances in the tools to detect these alterations have deepened our understanding of the underlying biology and tumor characteristics and have prompted the development of novel inhibitors targeting activated RTKs. The review focuses on the genetic and molecular structure of oncogenic RTKs, methods for diagnosis, therapeutic implications of tyrosine kinase inhibitors, and the use of liquid biopsies for monitoring the disease.
CANCER TREATMENT REVIEWS
(2022)
Article
Oncology
Tufia C. Haddad, Vera J. Suman, Antonino B. D'Assoro, Jodi M. Carter, Karthik V. Giridhar, Brendan P. McMenomy, Katelyn Santo, Erica L. Mayer, Meghan S. Karuturi, Aki Morikawa, P. Kelly Marcom, Claudine J. Isaacs, Sun Young Oh, Amy S. Clark, Ingrid A. Mayer, Khandan Keyomarsi, Timothy J. Hobday, Prema P. Peethambaram, Ciara C. O'Sullivan, Roberto A. Leon-Ferre, Minetta C. Liu, James N. Ingle, Matthew P. Goetz
Summary: This randomized clinical trial found that adding fulvestrant to treatment with alisertib did not increase objective tumor response rates (ORRs) or progression-free survival (PFS) in endocrine-resistant metastatic breast cancer (MBC).
Article
Oncology
Chunyan Li, Jiatao Liao, Xuanyi Wang, Fei Xavier Chen, Xiaomao Guo, Xingxing Chen
Summary: The purpose of this study was to investigate the radiosensitizing effects and underlying mechanisms of combined Aurora kinase A (AURKA) and CHK1 inhibition in triple-negative breast cancer (TNBC). The results showed that dual inhibition of AURKA and CHK1 not only enhanced TNBC radiosensitivity, but also induced cell apoptosis and DNA damage, leading to improved therapeutic efficacy. Additionally, it was found that both AURKA and CHK1 were overexpressed in TNBC patients and negatively correlated with patient survival.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Review
Biochemistry & Molecular Biology
Ruijuan Du, Chuntian Huang, Kangdong Liu, Xiang Li, Zigang Dong
Summary: AURKA is overexpressed in cancers and regulates substrate functions through phosphorylation, participating in various classic oncogenic pathways.
Article
Oncology
Manqiu Yang, Shufan Zhang, Rong Jiang, Shaomu Chen, Moli Huang
Summary: In cancer, ecDNA plays a crucial role in intercellular heterogeneity and tumor cell evolution due to its non-Mendelian inheritance. We developed circlehunter, a tool that uses enhanced chromatin accessibility to identify ecDNA from ATAC-Seq data. Circlehunter has an F1 score of 0.93 at 30x local depth and read lengths as short as 35 bp based on simulated data. Analysis of publicly available ATAC-Seq datasets revealed 37 oncogenes contained in ecDNA with amplification characteristics. Additionally, we found that ecDNA containing MYC in small cell lung cancer cell lines leads to MYC amplification and cis-regulation of NEUROD1 expression, resulting in a phenotype consistent with the NEUROD1 high expression subtype and sensitivity to Aurora kinase inhibitors. These findings highlight the value of circlehunter as a pipeline for investigating tumorigenesis.
Review
Chemistry, Physical
Priya, Shalini Jaswal, Ghanshyam Das Gupta, Sant Kumar Verma
Summary: Aurora kinase family plays a critical role in cell division and the cell cycle, and overexpression of AURKA and AURKB has been linked to the development of various carcinomas. The synthesis and development of Aurora Kinase inhibitors offer new opportunities for anticancer therapy.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biotechnology & Applied Microbiology
Leila Farhady Tooli, Mahdieh Shirzad, Mohammad Hossein Modarressi, Hanifeh Mirtavoos-Mahyari, Mohammad Ali Amoozegar, Sedigheh Hantoushzadeh, Elahe Motevaseli
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2019)
Article
Pathology
Mehdi Mohebi, Soudeh Ghafouri-Fard, Mohammad Hossein Modarressi, Sepideh Dashti, Ali Zekri, Vahid Kholghi-Oskooei, Mohammad Taheri
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Ashkan Safavi, Amirhosein Kefayat, Elham Mahdevar, Fatemeh Ghahremani, Navid Nezafat, Mohammad Hossein Modarressi
Summary: The study demonstrated that prophylactic co-immunization with multiepitope DNA and peptide cancer vaccines can significantly enhance the immune response against breast cancer, leading to reduced tumor volume and increased survival time in tumor-bearing mice. Further experiments are needed to evaluate their efficacy from different angles.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Genetics & Heredity
Elahe Valipour, Vajihe Taghdiri Nooshabadi, Shadi Mahdipour, Sasan Shabani, Leila Farhady-Tooli, Sina Majidian, Zahra Noroozi, Kamran Mansouri, Elaheh Motevaseli, Mohammad Hossein Modarressi
Article
Pathology
Ali Sattari, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard, Adeleh Alihashemi, Mir Davood Omrani, Ali Zekri, Mohammad Taheri
Summary: The study highlights the significant role of IFN-gamma-associated genes in the pathogenesis of breast cancer. These genes are up-regulated in cancer tissues and show strong correlations with nearby non-cancerous tissues. AC007278.3 gene is associated with breastfeeding duration and shows the best diagnostic power among the assessed genes.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Oncology
Bita Hassani, Mohammad Taheri, Yazdan Asgari, Ali Zekri, Ali Sattari, Soudeh Ghafouri-Fard, Farkhondeh Pouresmaeili
Summary: Breast cancer is commonly associated with elevated expression of GATA3, APTR, AC144450.1, and ZNF337.AS1, while lower levels of RAMP2.AS1 are observed. The expressions of GATA3 are correlated with the cancer staging, and FOXA1 and RAMP2.AS1 are associated with mitotic rate. FOXM1 and ZNF337.AS1 are linked to breastfeeding duration. The study suggests further investigation into the functional roles of APTR, AC144450.1, and ZNF337.AS1 in breast neoplasms.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ehsan Sohrabi, Masoumeh Moslemi, Ehsan Rezaie, Nahid Nafissi, Mansoor Khaledi, Hamed Afkhami, Javad Fathi, Ali Zekri
Summary: The study evaluated the expression of MCT3 (SLC16A8), MCT8 (SLC16A2), and MCT9 (SLC16A9) genes in breast cancer samples and compared to normal adjacent tissues. The results showed significantly lower expression of the MCT3 gene in breast cancer tissue, suggesting potential as a therapeutic target in breast cancer patients.
Article
Biochemistry & Molecular Biology
Roshanak S. Sajjadi, Mohammad Hossein Modarressi, Fahimeh Akbarian, Mohammad Amin Tabatabaiefar
Summary: This study utilized computational models to investigate the role of long noncoding RNAs in prostate cancer, identifying six high-value lncRNA targets through validation experiments. It revealed the relationship between these lncRNAs and coding genes associated with prostate cancer.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2021)
Article
Endocrinology & Metabolism
Soghra Khani, Mina Barzegari, Zahra Esmaeilizadeh, Pantea Farsian, Mohammadreza Alaei, Shadab Salehpour, Aria Setoodeh, Farzaneh Rohani, Ashraf Samavat, Ali Zekri, Roghieh Mirzazadeh, Sedigheh Sadeghi, Shohreh Khatami
Summary: This study evaluated biochemical factors, genetic mutations, treatment outcomes, and clinical follow-up data of Iranian patients with tetrahydrobiopterin (BH4) deficiency. Early diagnosis and treatment are crucial for improving clinical symptoms and preventing neurological impairments in BH4 deficiency patients. Most patients diagnosed at an early age had a proper response to treatment, while older patients may have poorer outcomes.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Zahra Noroozi, Mehdi Shamsara, Elahe Valipour, Sahar Esfandyari, Alireza Ehghaghi, Amir Monfaredan, Zahra Azizi, Elahe Motevaseli, Mohammad Hossein Modarressi
Summary: This study demonstrated that disrupting the HPV-E6 gene led to increased cell apoptosis and decreased cell proliferation. The antiproliferative effects of targeting HPV-E6 gene may provide therapeutic benefits for cervical cancer treatment.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Pouya Salehipour, Mojdeh Mahdiannasser, Ghazal Sedaghat Shayegan, Kimia Shankaie, Mina Tabrizi, Majid Mojarrad, Mohammad Hossein Modarressi
Summary: This study reports the development of a CRISPR-based fluorescent reporter (CBFR) assay for detecting the delE746_A750 subtype of EGFR exon 19 deletions. The CBFR assay offers a sensitive, specific, and simple strategy for detecting mutations, deletions, and pathogens in underequipped laboratories, and promoting personalized therapeutic approaches.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Samaneh Ghanbari, Elham Bayat, Masoumeh Azizi, Pezhman Fard-Esfahani, Mohammad Hossein Modarressi, Fatemeh Davami
Summary: Recombinant CHO cell line development traditionally relies on random integration (RI) approach, but targeted integration offers potential advantages in terms of control and stability. In this study, we used the CRISPR-mediated precise integration into target chromosome (CRIS-PITCh) system combined with the Bxb1 recombinase-mediated cassette exchange (RMCE) system to generate a transgene-expressing cell line with improved specificity and stability.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mozhgan Mondeali, Ali Etemadi, Khabat Barkhordari, Mina Mobini Kesheh, Sara Shavandi, Atefeh Bahavar, Fatemeh Hosseini Tabatabaie, Mohammad Mahmoudi Gomari, Mohammad H. Modarressi
Summary: Mutations in the spike protein of SARS-CoV-2, particularly the S477N mutation, can increase its binding affinity for ACE2 and lead to enhanced immune system evasion through new hydrogen and hydrophobic bonding. Computational analysis showed structural changes and increased stability in the spike protein due to this mutation.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Maryamsadat Shahidi, Omid Abazari, Parisa Dayati, Javad Zavar Reza, Mohammad Hossein Modarressi, Davood Tofighi, Bibi Fatemeh Haghiralsadat, Fatemeh Oroojalian
Summary: This study developed a nanoparticle-based delivery system consisting of selenium nanoparticles modified by chitosan and hyaluronic acid, which successfully delivered PLK1 siRNAs to bladder cancer cells. These findings suggest that hyaluronic acid-chitosan-selenium nanoparticles may provide a good vehicle for targeted gene therapy for bladder cancer.
Article
Genetics & Heredity
Seyyed Jafar Nosratabadi, Nasim Hayati Roodbari, Ali Afgar, Mohammad Hossein Modarressi, Alireza Farsinejad, Majid Fasihi Harandi
