Cancer‐associated mutations in VAV1 trigger variegated signaling outputs and T‐cell lymphomagenesis

Lysine Acetylation Reshapes the Downstream Signaling Landscape of Vav1 in Lymphocytes

(2020) Sonia Rodríguez-Fdez et al.   Cells

CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells

(2020) Ankita Mitra et al.   Frontiers in Immunology

Advances in understanding of angioimmunoblastic T-cell lymphoma

(2020) Shigeru Chiba et al.   LEUKEMIA

VAV1 mutations contribute to development of T-cell neoplasms in mice

(2020) Kota Fukumoto et al.   BLOOD

VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma

(2020) L. Francisco Lorenzo-Martín et al.   Nature Communications

New preclinical models for angioimmunoblastic T-cell lymphoma: filling the GAP

(2020) Rana Mhaidly et al.   Oncogenesis

Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma

(2019) Tayla B. Heavican et al.   BLOOD

Integration of transcriptional and mutational data simplifies the stratification of peripheral T‐cell lymphoma

(2019) Francesco Maura et al.   AMERICAN JOURNAL OF HEMATOLOGY

The Vav GEF Family: An Evolutionary and Functional Perspective

(2019) Sonia Rodríguez-Fdez et al.   Cells

TOX is a critical regulator of tumour-specific T cell differentiation

(2019) Andrew C. Scott et al.   NATURE

The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility

(2019) Wei Xu et al.   IMMUNITY

RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis

(2018) Jose R. Cortes et al.   CANCER CELL

New insights into the Vav1 activation cycle in lymphocytes

(2018) María Barreira et al.   CELLULAR SIGNALLING

Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis

(2017) Shengbing Zang et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel TCR-Mediated Mechanisms of Notch Activation and Signaling

(2017) Martin Peter Steinbuck et al.   JOURNAL OF IMMUNOLOGY

Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas

(2017) Francesco Abate et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma

(2016) R. L. Boddicker et al.   BLOOD

Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas

(2016) D. Vallois et al.   BLOOD

Cutting Edge: NFAT Transcription Factors Promote the Generation of Follicular Helper T Cells in Response to Acute Viral Infection

(2016) Gustavo J. Martinez et al.   JOURNAL OF IMMUNOLOGY

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

(2016) Joshua D Campbell et al.   NATURE GENETICS

DNM3 Attenuates Hepatocellular Carcinoma Growth by Activating P53

(2016) Zhengdong Zhang et al.   MEDICAL SCIENCE MONITOR

IL-21–Driven Neoplasms in SJL Mice Mimic Some Key Features of Human Angioimmunoblastic T-Cell Lymphoma

(2015) Shweta Jain et al.   AMERICAN JOURNAL OF PATHOLOGY

hnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies

(2015) Miguel Gallardo et al.   CANCER CELL

Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma

(2015) Ramona Crescenzo et al.   CANCER CELL

BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms

(2015) Katerina Hatzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Integrated molecular analysis of adult T cell leukemia/lymphoma

(2015) Keisuke Kataoka et al.   NATURE GENETICS

Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes

(2014) J. S. Weinstein et al.   BLOOD

A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma

(2014) Hae Yong Yoo et al.   NATURE GENETICS

The C-Terminal SH3 Domain Contributes to the Intramolecular Inhibition of Vav Family Proteins

(2014) M. Barreira et al.   Science Signaling

c-Jun/c-Fos heterodimers regulate cellular genes via a newly identified class of methylated DNA sequence motifs

(2013) M. Gustems et al.   NUCLEIC ACIDS RESEARCH

The Rho Exchange Factors Vav2 and Vav3 Favor Skin Tumor Initiation and Promotion by Engaging Extracellular Signaling Loops

(2013) Mauricio Menacho-Márquez et al.   PLOS BIOLOGY

Human Vav1 Expression in Hematopoietic and Cancer Cell Lines Is Regulated by c-Myb and by CpG Methylation

(2012) Lena Ilan et al.   PLoS One

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

(2010) Bingke Yu et al.   CELL

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Crucial structural role for the PH and C1 domains of the Vav1 exchange factor

(2008) Jonathan Rapley et al.   EMBO REPORTS

Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1

(2008) Xiaoyu Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1

(2008) Jill E. Chrencik et al.   JOURNAL OF MOLECULAR BIOLOGY