Targeting the Angiopoietin/Tie Pathway: Prospects for Treatment of Retinal and Respiratory Disorders

Gene expression in the angiopoietin/TIE axis is altered in peripheral tissue of ovarian cancer patients: A prospective observational study

(2021) Alexander Kinnen et al.   LIFE SCIENCES

Dynamic angiopoietin-2 assessment predicts survival and chronic course in hospitalized patients with COVID-19

(2021) Erica Villa et al.   Blood Advances

Associations of Angiopoietins With Heart Failure Incidence and Severity

(2021) Brandon S. Peplinski et al.   JOURNAL OF CARDIAC FAILURE

Diabetic and Retinal Vascular Eye Disease

(2021) Hong-Gam Le et al.   MEDICAL CLINICS OF NORTH AMERICA

Coronavirus Disease 2019: Coronaviruses and Blood Safety

(2020) Le Chang et al.   TRANSFUSION MEDICINE REVIEWS

Investigation of the Possible Role of Tie2 Pathway and TEK Gene in Asthma and Allergic Conjunctivitis

(2020) Zsófia Gál et al.   Frontiers in Genetics

Vascular Changes Detected With Thoracic CT in Coronavirus Disease (COVID-19) Might Be Significant Determinants for Accurate Diagnosis and Optimal Patient Management

(2020) Salah D. Qanadli et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients

(2020) David M. Smadja et al.   ANGIOGENESIS

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

Novel angiogenesis strategy to ameliorate pulmonary hypertension

(2020) Haoran Miao et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

First-in-human, dose-escalation, phase 1 study of anti-angiopoietin-2 LY3127804 as monotherapy and in combination with ramucirumab in patients with advanced solid tumours

(2020) Juan Martin-Liberal et al.   BRITISH JOURNAL OF CANCER

Safety and Efficacy of Different Doses and Regimens of Faricimab vs Ranibizumab in Neovascular Age-Related Macular Degeneration

(2020) Jayashree Sahni et al.   JAMA Ophthalmology

Efficacy of Every Four Monthly and Quarterly Dosing of Faricimab vs Ranibizumab in Neovascular Age-Related Macular Degeneration

(2020) Arshad M. Khanani et al.   JAMA Ophthalmology

The amino-terminal oligomerization domain of Angiopoietin-2 affects vascular remodeling, mammary gland tumor growth, and lung metastasis in mice

(2020) Emmi Kapiainen et al.   CANCER RESEARCH

Timed Ang2-targeted therapy identifies the Angiopoietin-Tie pathway as key regulator of fatal lymphogenous metastasis

(2020) Nicolas Gengenbacher et al.   Cancer Discovery

Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

(2019) Jaeryung Kim et al.   Science Advances

Simultaneous Inhibition of Angiopoietin-2 and VEGF-A with Faricimab in Diabetic Macular Edema: BOULEVARD Phase 2 Randomized Trial

(2019) Jayashree Sahni et al.   OPHTHALMOLOGY

Angiopoietin-2 as a Marker of Retinopathy in Children and Adolescents With Sickle Cell Disease

(2019) Nevine G. Andrawes et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology

(2019) Racheal G. Akwii et al.   Cells

Vascular Inflammation Risk Factors in Retinal Disease

(2019) Ileana Soto et al.   Annual Review of Vision Science

Tie-2/Angiopoietin pathway modulation as a therapeutic strategy for retinal disease

(2019) Rehan M. Hussain et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Faricimab: expanding horizon beyond VEGF

(2019) Ashish Sharma et al.   EYE

The contribution of dietary and plasma folate and cobalamin to levels of angiopoietin-1, angiopoietin-2 and Tie-2 receptors depend on vascular endothelial growth factor status of primary breast cancer patients

(2019) Saeed Pirouzpanah et al.   Scientific Reports

Variation in the TEK gene is not associated with asthma but with allergic conjunctivitis

(2018) L. E. Fodor et al.   International Journal of Immunogenetics

Diabetic Retinopathy: Pathophysiology and Treatments

(2018) Wei Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP

(2018) Tomokazu Souma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinal vasculature development in health and disease

(2018) Senthil Selvam et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Mechanisms of macular edema: Beyond the surface

(2018) Alejandra Daruich et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Ang-2 promotes lung cancer metastasis by increasing epithelial-mesenchymal transition

(2018) Zhizhen Dong et al.   Oncotarget

Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis

(2018) John P. Reilly et al.   INTENSIVE CARE MEDICINE

Age-related macular degeneration

(2018) Paul Mitchell et al.   LANCET

Aerosolised Mesenchymal Stem Cells Expressing Angiopoietin-1 Enhances Airway Repair

(2018) N. S. S. Halim et al.   Stem Cell Reviews and Reports

Modulation of long-term endothelial-barrier integrity is conditional to the cross-talk between Akt and Src signaling

(2017) Fei Gao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Impaired angiopoietin/Tie2 signaling compromises Schlemm’s canal integrity and induces glaucoma

(2017) Jaeryung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of serum angiopoietin-2 levels in progression and prognosis of lung cancer

(2017) Yuyang Xu et al.   MEDICINE

Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization

(2017) Veli-Matti Leppänen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiogenic and inflammatory biomarkers in the differentiation of pulmonary hypertension

(2017) Joanna Säleby et al.   SCANDINAVIAN CARDIOVASCULAR JOURNAL

Novel therapeutic targets in diabetic macular edema: Beyond VEGF

(2017) Elizabeth A. Urias et al.   VISION RESEARCH

Elevated angiopoietin 2 in aqueous of patients with neovascular age related macular degeneration correlates with disease severity at presentation

(2017) Danny S. Ng et al.   Scientific Reports

Recent developments in age-related macular degeneration: a review

(2017) Waseem Al-Zamil et al.   Clinical Interventions in Aging

Circulating angiopoietin-1 and -2 in patients with stable and exacerbated asthma

(2016) Pureun-Haneul Lee et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems

(2016) L. Eklund et al.   CLINICAL SCIENCE

Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases

(2016) Jörg T Regula et al.   EMBO Molecular Medicine

Regulation of angiopoietin-2 secretion from human pulmonary microvascular endothelial cells

(2016) Ji Young Lee et al.   EXPERIMENTAL LUNG RESEARCH

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

(2016) Minah Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Tie1 controls angiopoietin function in vascular remodeling and inflammation

(2016) Emilia A. Korhonen et al.   JOURNAL OF CLINICAL INVESTIGATION

The use of CrossMAb technology for the generation of bi- and multispecific antibodies

(2016) Christian Klein et al.   mAbs

Enhanced Benefit in Diabetic Macular Edema from AKB-9778 Tie2 Activation Combined with Vascular Endothelial Growth Factor Suppression

(2016) Peter A. Campochiaro et al.   OPHTHALMOLOGY

Five-Year Outcomes with Anti–Vascular Endothelial Growth Factor Treatment of Neovascular Age-Related Macular Degeneration

(2016) Maureen G. Maguire et al.   OPHTHALMOLOGY

Angiopoietin-2 expression in patients with an acute exacerbation of idiopathic interstitial pneumonias

(2016) Masaru Ando et al.   RESPIRATORY MEDICINE

Amelioration of sepsis by TIE2 activation–induced vascular protection

(2016) Sangyeul Han et al.   Science Translational Medicine

Angiopoietin 2 induces astrocyte apoptosis via αvβ5-integrin signaling in diabetic retinopathy

(2016) J-H Yun et al.   Cell Death & Disease

Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

(2016) Man Chu et al.   eLife

Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory

(2016) Pedro Romero-Aroca et al.   Journal of Diabetes Research

Circulating Angiopoietin-1 Is Not a Biomarker of Disease Severity or Prognosis in Pulmonary Hypertension

(2016) Manuel Jonas Richter et al.   PLoS One

A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti-Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors

(2015) K. P. Papadopoulos et al.   CLINICAL CANCER RESEARCH

Vasculotide reduces endothelial permeability and tumor cell extravasation in the absence of binding to or agonistic activation of Tie2

(2015) F. T. Wu et al.   EMBO Molecular Medicine

Ranibizumab for the treatment of wet AMD: a summary of real-world studies

(2015) V Chong   EYE

Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin

(2015) Maike Frye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Diabetic Macular Edema: Pathophysiology and Novel Therapeutic Targets

(2015) Arup Das et al.   OPHTHALMOLOGY

The Tie2-agonist Vasculotide rescues mice from influenza virus infection

(2015) Michael G. Sugiyama et al.   Scientific Reports

Efficacy of Tie2 Receptor Antagonism in Angiosarcoma

(2015) Jason R. Hasenstein et al.   NEOPLASIA

Evaluation of angiopoietin 1 and 2, vascular endothelial growth factor, and tumor necrosis factor alpha levels in asthmatic children

(2014) Burcu Tahire Köksal et al.   ALLERGY AND ASTHMA PROCEEDINGS

Lymphatic regulator PROX1 determines Schlemm’s canal integrity and identity

(2014) Dae-Young Park et al.   JOURNAL OF CLINICAL INVESTIGATION

The Schlemm’s canal is a VEGF-C/VEGFR-3–responsive lymphatic-like vessel

(2014) Aleksanteri Aspelund et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature

(2014) Jikui Shen et al.   JOURNAL OF CLINICAL INVESTIGATION

EXACERBATION OF CHOROIDAL AND RETINAL PIGMENT EPITHELIAL ATROPHY AFTER ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR TREATMENT IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

(2014) Mei Young et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Serum angiopoietin is associated with lung function in patients with asthma: a retrospective cohort study

(2014) Kuk-Young Moon et al.   BMC Pulmonary Medicine

Angiopoietin signaling in the vasculature

(2013) Lauri Eklund et al.   EXPERIMENTAL CELL RESEARCH

Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression

(2013) Shom Goel et al.   JNCI-Journal of the National Cancer Institute

Expression of angiopoietin-TIE system components in angiosarcoma

(2013) Darya Buehler et al.   MODERN PATHOLOGY

Antiangiogenic Therapy for Ischemic Retinopathies

(2013) M. Al-Latayfeh et al.   Cold Spring Harbor Perspectives in Medicine

Increased levels of angiopoietins 1 and 2 in sputum supernatant in severe refractory asthma

(2012) E. Tseliou et al.   ALLERGY

Increased Hyperoxia-Induced Lung Injury in Nitric Oxide Synthase 2 Null Mice Is Mediated via Angiopoietin 2

(2012) Vineet Bhandari et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tie1 regulates the Tie2 agonistic role of angiopoietin-2 in human lymphatic endothelial cells

(2012) Sun-Hwa Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Plasma angiopoietin-2 in clinical acute lung injury

(2012) Carolyn S. Calfee et al.   CRITICAL CARE MEDICINE

Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*

(2012) Sascha David et al.   CRITICAL CARE MEDICINE

Angiopoietin-2 is a potential mediator of endothelial barrier dysfunction following cardiopulmonary bypass

(2012) Christian Clajus et al.   CYTOKINE

Management of retinal vascular diseases: a patient-centric approach

(2012) C S Brand   EYE

Targeted deletion of Vegfa in adult mice induces vision loss

(2012) Toshihide Kurihara et al.   JOURNAL OF CLINICAL INVESTIGATION

The acute respiratory distress syndrome

(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex

(2012) Imran Bhutto et al.   MOLECULAR ASPECTS OF MEDICINE

The Molecular Balance between Receptor Tyrosine Kinases Tie1 and Tie2 Is Dynamically Controlled by VEGF and TNFα and Regulates Angiopoietin Signalling

(2012) Harprit Singh et al.   PLoS One

Plexiform Lesions in Pulmonary Arterial Hypertension

(2011) Danny Jonigk et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality

(2011) Sascha David et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Angiopoietin-1/Tie2 Signal Augments Basal Notch Signal Controlling Vascular Quiescence by Inducing Delta-Like 4 Expression through AKT-mediated Activation of β-Catenin

(2011) Jianghui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo

(2011) Andre Broermann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

How does hypertension affect your eyes?

(2011) M Bhargava et al.   JOURNAL OF HUMAN HYPERTENSION

Serum Tie2 levels: clinical association with microangiopathies in patients with systemic sclerosis

(2011) S. Noda et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Increased Expression of Angiopoietins and Tie2 in the Lungs of Chronic Asthmatic Mice

(2010) Toluwalope O. Makinde et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

An Autocrine Linkage Between Matrix Metalloproteinase-14 and Tie-2 Via Ectodomain Shedding Modulates Angiopoietin-1–Dependent Function in Endothelial Cells

(2010) Mitsuho Onimaru et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Circulating angiopoietins in idiopathic pulmonary arterial hypertension

(2010) Philipp Kümpers et al.   EUROPEAN HEART JOURNAL

Randomized Trial Evaluating Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema

(2010) Michael J. Elman et al.   OPHTHALMOLOGY

Regulation of the Pulmonary Circulation in the Fetus and Newborn

(2010) Yuansheng Gao et al.   PHYSIOLOGICAL REVIEWS

Phosphorylation of endothelial nitric oxide synthase by atypical PKC  contributes to angiopoietin-1-dependent inhibition of VEGF-induced endothelial permeability in vitro

(2009) M. Oubaha et al.   BLOOD

Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases

(2009) Harprit Singh et al.   CELLULAR SIGNALLING

Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface

(2009) Tania M. Hansen et al.   CELLULAR SIGNALLING

Increased levels of angiopoietin-2 in induced sputum from smoking asthmatic patients

(2009) H. Kanazawa et al.   CLINICAL AND EXPERIMENTAL ALLERGY

VE-PTP controls blood vessel development by balancing Tie-2 activity

(2009) Mark Winderlich et al.   JOURNAL OF CELL BIOLOGY

The angiopietin-1–Tie2 pathway prevents rather than promotes pulmonary arterial hypertension in transgenic mice

(2009) Lakshmi Kugathasan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Exercise improvement and plasma biomarker changes with intravenous treprostinil therapy for pulmonary arterial hypertension: A placebo-controlled trial

(2009) Jagdish Hiremath et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium

(2009) H. T. Yuan et al.   MOLECULAR AND CELLULAR BIOLOGY

An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris

(2009) M. Saint-Geniez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiopoietin-1 Protects against Airway Inflammation and Hyperreactivity in Asthma

(2008) Davina C. M. Simoes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hypertension and the eye

(2008) John T DellaCroce et al.   CURRENT OPINION IN OPHTHALMOLOGY

Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

(2008) Julie Gavard et al.   DEVELOPMENTAL CELL

Is blockade of vascular endothelial growth factor beneficial for all types of diabetic retinopathy?

(2008) D. N. Sang et al.   DIABETOLOGIA

Angiopoietin-1 Induces Krüppel-like Factor 2 Expression through a Phosphoinositide 3-Kinase/AKT-dependent Activation of Myocyte Enhancer Factor 2

(2008) Keisuke Sako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF

(2008) Astrid F. Nottebaum et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

(2008) Pipsa Saharinen et al.   NATURE CELL BIOLOGY

Regulation of retinal blood flow in health and disease

(2008) Constantin J. Pournaras et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Immunological mechanisms in the pathogenesis of diabetic retinopathy

(2008) Anthony P. Adamis et al.   Seminars in Immunopathology

Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients

(2008) M van der Heijden et al.   THORAX

Acceleration of Diabetic Wound Healing by an Angiopoietin Peptide Mimetic

(2008) Paul Van Slyke et al.   TISSUE ENGINEERING PART A

Endothelium as master regulator of organ development and growth

(2008) Daniela Tirziu et al.   VASCULAR PHARMACOLOGY

Angiopoietin-2 as a contributing factor of exercise-induced bronchoconstriction in asthmatic patients receiving inhaled corticosteroid therapy

(2007) Hiroshi Kanazawa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY