Lymphatic regulator PROX1 determines Schlemm’s canal integrity and identity

A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy

(2013) René Hägerling et al.   EMBO JOURNAL

Endothelial ERK signaling controls lymphatic fate specification

(2013) Yong Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

A pathway for unicellular tube extension depending on the lymphatic vessel determinant Prox1 and on osmoregulation

(2013) Irina Kolotuev et al.   NATURE CELL BIOLOGY

Angiopoietin-1 Guides Directional Angiogenesis Through Integrin  v 5 Signaling for Recovery of Ischemic Retinopathy

(2013) J. Lee et al.   Science Translational Medicine

Sox17 is indispensable for acquisition and maintenance of arterial identity

(2013) Monica Corada et al.   Nature Communications

Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome

(2012) Abdenour Soufi et al.   CELL

9-Cis Retinoic Acid Promotes Lymphangiogenesis and Enhances Lymphatic Vessel Regeneration

(2012) Inho Choi et al.   CIRCULATION

Mechanotransduction, PROX1, and FOXC2 Cooperate to Control Connexin37 and Calcineurin during Lymphatic-Valve Formation

(2012) Amélie Sabine et al.   DEVELOPMENTAL CELL

The effects of anesthesia, mouse strain and age on intraocular pressure and an improved murine model of experimental glaucoma

(2012) Frances E. Cone et al.   EXPERIMENTAL EYE RESEARCH

Role of shear-stress-induced VEGF expression in endothelial cell survival

(2012) Nathaniel G. dela Paz et al.   JOURNAL OF CELL SCIENCE

Blood flow reprograms lymphatic vessels to blood vessels

(2012) Chiu-Yu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

3D simulation of the aqueous flow in the human eye

(2012) Adan Villamarin et al.   MEDICAL ENGINEERING & PHYSICS

Mechanoinduction of lymph vessel expansion

(2011) Lara Planas-Paz et al.   EMBO JOURNAL

Pulsatile flow into the aqueous veins: Manifestations in normal and glaucomatous eyes

(2011) Murray Johnstone et al.   EXPERIMENTAL EYE RESEARCH

Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves

(2011) R. S. Srinivasan et al.   GENES & DEVELOPMENT

Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma

(2011) Gulab S. Zode et al.   JOURNAL OF CLINICAL INVESTIGATION

Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice

(2011) Eleni Bazigou et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanical responsiveness of the endothelial cell of Schlemm's canal: scope, variability and its potential role in controlling aqueous humour outflow

(2011) E. H. Zhou et al.   Journal of the Royal Society Interface

The lymphatic vasculature in disease

(2011) Kari Alitalo   NATURE MEDICINE

Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse

(2010) I. Choi et al.   BLOOD

Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage

(2010) Young Jun Koh et al.   CANCER CELL

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

Glaucoma: genes, phenotypes, and new directions for therapy

(2010) Bao Jian Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

Conversion of vascular endothelial cells into multipotent stem-like cells

(2010) Damian Medici et al.   NATURE MEDICINE

Integrin-α9 Is Required for Fibronectin Matrix Assembly during Lymphatic Valve Morphogenesis

(2009) Eleni Bazigou et al.   DEVELOPMENTAL CELL

Uveoscleral outflow – A review

(2009) Albert Alm et al.   EXPERIMENTAL EYE RESEARCH

Decreased Intraocular Pressure in Mice Following Either Pharmacological or Genetic Inhibition of ROCK

(2009) N. Andrew Whitlock et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

KLF4 Interacts with  -Catenin/TCF4 and Blocks p300/CBP Recruitment by  -Catenin

(2009) P. M. Evans et al.   MOLECULAR AND CELLULAR BIOLOGY

Lymphatic Precollectors Contain a Novel, Specialized Subpopulation of Podoplaninlow, CCL27-Expressing Lymphatic Endothelial Cells

(2008) Nikolaus Wick et al.   AMERICAN JOURNAL OF PATHOLOGY

Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate

(2008) S. Lee et al.   BLOOD

Cell-autonomous requirement for  1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice

(2008) T. R. Carlson et al.   DEVELOPMENT

Extracellular matrix in the trabecular meshwork

(2008) Ted S. Acott et al.   EXPERIMENTAL EYE RESEARCH

The changing paradigm of outflow resistance generation: Towards synergistic models of the JCT and inner wall endothelium

(2008) Darryl R. Overby et al.   EXPERIMENTAL EYE RESEARCH

Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity

(2008) N. C. Johnson et al.   GENES & DEVELOPMENT

Emilin1 Deficiency Causes Structural and Functional Defects of Lymphatic Vasculature

(2008) C. Danussi et al.   MOLECULAR AND CELLULAR BIOLOGY

Sox18 induces development of the lymphatic vasculature in mice

(2008) Mathias François et al.   NATURE

A core Klf circuitry regulates self-renewal of embryonic stem cells

(2008) Jianming Jiang et al.   NATURE CELL BIOLOGY

Adrenomedullin signaling is necessary for murine lymphatic vascular development

(2007) Kimberly L. Fritz-Six et al.   JOURNAL OF CLINICAL INVESTIGATION