Article
Medicine, General & Internal
Indre Bileviciute-Ljungar, Jan-Rickard Norrefalk, Kristian Borg
Summary: A significant number of post-COVID-19 syndrome sufferers experience pain, highlighting the urgent need for pain management.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Bruna Spolador de Alencar Silva, Telmo Pereira, Luciele Guerra Minuzzi, Camila Souza Padilha, Caique Figueiredo, Tiago Olean-Oliveira, Ivete Vera Medeiros dos Santos, Ana Elisa von Ah Morano, Osmar Marchioto, Jose Procopio Jabur Ribeiro, Vanessa Ribeiro Dos Santos, Marilia Seelaender, Alexandre Abilio Teixeira, Ronaldo Vagner T. Dos Santos, Valdir de Aquino Lemos, Ana Paula Coelho Figueira Freire, Gilson Pires Dorneles, Bruna Marmett, Andre Olean-Oliveira, Marcos F. S. Teixeira, Patricia M. Seraphim, Armando Caseiro, Ricardo Aurino Pinho, Hashim Islam, Jonathan Peter Little, Karsten Krueger, Jose Cesar Rosa-Neto, Manuel-Joao Coelho-E-Silva, Fabio Santos Lira
Summary: This study aimed to evaluate the association between physical activity and immunometabolic responses in young adults after mild-to-moderate COVID-19 infection. The results showed that COVID-19 patients had lower physical activity levels and exhibited impacts on lung function, immune cell phenotype, and cytokine production.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Areej Alfaifi, Ahmed S. Sultan, Daniel Montelongo-Jauregui, Timothy F. Meiller, Mary Ann Jabra-Rizk
Summary: Despite various oral conditions observed in COVID-19 patients, the importance of the oral cavity as a site of SARS-CoV-2 infection is often overlooked. This study demonstrates that SARS-CoV-2 can replicate in salivary epithelial cells, leading to inflammation and atrophy of salivary glands. Histatin-5, an important component of saliva, is significantly reduced in COVID-19 patients, compromising its antimicrobial activity and potentially leading to oral symptoms such as dysesthesia and dysgeusia. These findings suggest a need for reassessment of the implications of COVID-19 on oral health.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Sevket Balta, Ilknur Balta
Summary: This review assesses the relationship between inflammatory markers and COVID-19 infection, including both known and emerging markers. These markers play important roles in follow-up, treatment response assessment, and risk stratification.
CURRENT VASCULAR PHARMACOLOGY
(2022)
Review
Microbiology
Anna Malkova, Igor Kudryavtsev, Anna Starshinova, Dmitry Kudlay, Yulia Zinchenko, Anzhela Glushkova, Piotr Yablonskiy, Yehuda Shoenfeld
Summary: Post COVID-19 Syndrome (PCS) is a complex of various symptoms that develop a month or more after the acute phase of the disease, mainly occurring in women. It may be associated with brain damage and possibly caused by autoimmune damage to neurons, glia, and cerebral vessels.
Article
Immunology
Silke Lauren Sommen, Lise Beier Havdal, Joel Selvakumar, Gunnar Einvik, Truls Michael Leegaard, Fridtjof Lund-Johansen, Annika E. E. Michelsen, Tom E. E. Mollnes, Tonje Stiansen-Sonerud, Trygve Tjade, Vegard Bruun Bratholm Wyller, Lise Lund Berven
Summary: This study investigated immunological markers and pulmonary function in COVID-19 convalescents at 6 months after mild infection. The results showed that although there was an increase in chemokines among the COVID-19 convalescents, it was not associated with long-lasting symptoms of COVID-19.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Idris Boudhabhay, Marion Rabant, Lubka T. Roumenina, Louis-Marie Coupry, Victoria Poillerat, Armance Marchal, Veronique Fremeaux-Bacchi, Khalil El Karoui, Mehran Monchi, Franck Pourcine
Summary: This case report describes a 46-year-old male patient with post-COVID-19 MIS-A, who showed significant improvement in renal function after specific complement inhibition treatment, indicating that TMA may play a crucial role in the pathophysiology of post-COVID-19 MIS-A.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
A. Karabulut, M. S. Ahin
Summary: The study found that neopterin levels were not elevated in patients with mild/moderate COVID-19, although other inflammatory markers showed significant differences. White blood cell, platelet, and hemoglobin levels may serve as predictive markers for COVID-19.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Health Care Sciences & Services
Ekaterina Sorokina, Alisa Pautova, Oleg Fatuev, Vladislav Zakharchenko, Alexander Onufrievich, Andrey Grechko, Natalia Beloborodova, Ekaterina Chernevskaya
Summary: Post-COVID-19 syndrome is a complex condition that leads to impairment in multiple body systems after COVID-19 infection. A study examined the clinical, laboratory, and gut disorders in patients with post-COVID-19 syndrome before and after a 14-day rehabilitation program. The results showed improvements in respiratory function, general well-being, and mood, but some metabolic and inflammatory variables did not fully recover during the program. The study also found imbalances in the gut microbiota of patients. The authors suggest that personalized rehabilitation programs should consider not only biomarker levels, but also the individual taxonomy of the gut microbiota.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Fabrice Cognasse, Hind Hamzeh-Cognasse, Mickael Rosa, Delphine Corseaux, Brigitte Bonneaudeau, Chloe Pierre, Julie Huet, Charles Antoine Arthaud, Marie Ange Eyraud, Amelie Prier, Anne Claire Duchez, Theo Ebermeyer, Marco Heestermans, Estelle Audoux-Caire, Quentin Philippot, Tom Le Voyer, Olivier Hequet, Anne-Marie Fillet, Patricia Chavarin, Dominique Legrand, Pascale Richard, France Pirenne, Pierre Gallian, Jean Laurent Casanova, Sophie Susen, Pascal Morel, Karine Lacombe, Paul Bastard, Pierre Tiberghien
Summary: COVID-19 convalescent plasma (CCP) contains neutralising antibodies that may be useful as passive immunotherapy. CCP showed increased levels of IL-6 and TNF-alpha and lower levels of IL-10 compared to control plasma. Auto-Antibodies against type I IFNs in CCP were not associated with reported adverse events. Further studies are needed to define the clinical relevance of these findings.
Article
Medicine, General & Internal
Ali Razaghi, Attila Szakos, Marwa Alouda, Bela Bozoky, Mikael Bjornstedt, Laszlo Szekely
Summary: Critically ill COVID-19 patients with pleural effusion have a higher risk of longer hospitalization, multisystem inflammatory syndrome, and mortality. The study evaluated the pleural effusions of deceased COVID-19 patients and identified elevated levels of various protein markers, indicating overstimulation of the immune system and cytokine storm. The study also found damage to arterial and cardiovascular organs. Certain markers, such as CA12, CD40, IL-6, IL-8, PD-L1, and VEGFA, showed potential as biomarkers for disease severity and prognosis or as therapy targets. Additionally, the involvement of JAK/STAT pathways in hyperinflammation suggests the potential use of JAK inhibitors as an effective treatment.
Article
Medicine, General & Internal
Lou'i Al-Husinat, Mokeem Nusir, Haitham Al-Gharaibeh, Amer A. Alomari, Mahmoud M. Smadi, Denise Battaglini, Paolo Pelosi
Summary: This study investigated the prevalence and risk factors of post-COVID syndrome (PCS) among individuals in Jordan who had previous mild to moderate COVID-19 infection. The results showed that mood disturbance was the most common PCS symptom, followed by fatigue, anxiety, and myalgia. Female gender significantly increased the risk for multiple PCS symptoms, and age < 30 years was found to be an independent risk factor for myalgia.
FRONTIERS IN MEDICINE
(2022)
Article
Nutrition & Dietetics
Anouk A. F. Stoffels, Esther L. van Voorthuizen, Hieronymus W. H. van Hees, Jeannette B. Peters, Hanneke A. C. van Helvoort, Nicol C. Voermans, Jonne Doorduin, Bram van den Borst
Summary: This study found that muscle weakness is a common and clinically relevant symptom after COVID-19, with poor long-term improvement. Diabetes and hospital length of stay were identified as possible predictors of muscle weakness following COVID-19 hospitalization.
Article
Public, Environmental & Occupational Health
Santosh Kumar Sidhwani, Talat Mirza, Ambrina Khatoon, Fouzia Shaikh, Rizma Khan, Omer Ahmed Shaikh, Abdulqadir J. Nashwan
Summary: This study aimed to investigate the correlation between inflammatory markers and the severity of COVID-19. The results showed a significant association between all markers, except procalcitonin, and disease severity. These findings could enhance our understanding of COVID-19 pathogenesis and aid in predicting and managing severe cases.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Miguel A. Hernandez-Hernandez, Laura Sanchez-Moreno, Pedro Orizaola, David Iturbe, Carlos Alvarez, Sonia Fernandez-Rozas, Vanesa Gonzalez-Novoa, Javier Llorca, Jose L. Hernandez, Jose L. Fernandez, Jose A. Parra
Summary: Phrenic nerve injury (PNI) is a common complication after lung transplantation, associated with surgical factors, and the main risk factors include age, bilateral lung transplantation, female gender, and technical difficulties during surgery.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Review
Medicine, General & Internal
Diana Prieto-Pena, Javier G. Ocejo-Vinyals, Joel Mazariegos-Cano, Ana L. Pelayo-Negro, Sara Remuzgo-Martinez, Fernanda Genre, Alicia Garcia-Dorta, Monica Renuncio-Garcia, Victor M. Martinez-Taboada, Carmen Garcia-Ibarbia, Julio Sanchez-Martin, Marcos Lopez-Hoyos, Ricardo Blanco, Miguel A. Gonzalez-Gay, Jose L. Hernandez
Summary: This study characterized the demographic, genetic, clinical, and serological features of patients with anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) immune-mediated necrotizing myopathy (IMNM) in a region of northern Spain. It was found that this disease primarily affects individuals over 50 years of age who carry the HLA-DRB1*11 allele and use statins. Low vitamin D levels and hypothyroidism may also play a predisposing role.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Gabriel Garate, Marta Pascual, Montserrat Rivero, Maria Toriello, Sara Perez-Pereda, Vicente Gonzalez-Quintanilla, Jorge Madera, Manuel Gutierrez-Cuadra, Maria del Carmen Farinas, Jose Luis Hernandez, Jose Manuel Olmos, Julio Pascual
Summary: The study compared circulating levels of CGRP alpha and CGRP beta in healthy controls and hospitalized COVID-19 patients, and analyzed the impact of comorbidities and treatments on these concentrations. The results showed significantly higher levels of both CGRP isoforms in COVID-19 patients compared to controls, and the presence of arterial hypertension, obesity, or corticosteroid treatment affected the serum concentration of CGRP alpha.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Medical Laboratory Technology
Daniel Martinez-Revuelta, Juan Irure-Ventura, Marcos Lopez-Hoyos, Jose Manuel Olmos, Emilio Pariente, Marta Martin-Millan, Daniel Nan, Alejandra Comins-Boo, Victor Manuel Martinez-Taboada, Jose Luis Hernandez
Summary: Autoantibodies, specifically antinuclear antibodies (ANA), are characteristic features of systemic autoimmune diseases (AID). This study compares the diagnostic performance of three different methods for ANA screening (indirect immunofluorescence [IIF], addressable laser bead immunoassay [ALBIA], and fluorescence enzyme immunoassay [FEIA]).
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jose Luis Perez-Castrillon, Antonio Duenas-Laita, Carlos Gomez-Alonso, Esteban Jodar, Javier del Pino-Montes, Maria Luisa Brandi, Fernando Cereto Castro, Jose Manuel Quesada-Gomez, Laura Gallego Lopez, Jose Manuel Olmos Martinez, Maria Rosa Alhambra Exposito, Bernat Galarraga, Jesus Gonzalez-Macias, Jose Luis Neyro, Roger Bouillon, Gonzalo Hernandez-Herrero, Nieves Fernandez-Hernando, Sandra P. Chinchilla
Summary: This report presents the results of a 1-year clinical trial comparing the efficacy and safety of monthly calcifediol and cholecalciferol in postmenopausal women with vitamin D deficiency. The study found that monthly calcifediol is an effective and safe treatment, maintaining stable vitamin D levels.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Carmen Gomez-Vaquero, Jose Luis Hernandez, Jose Manuel Olmos, Dacia Cerda, Cristina Hidalgo Calleja, Juan Antonio Martinez Lopez, Luis Arboleya, Francisco Javier Aguilar del Rey, Silvia Martinez Pardo, Inmaculada Ros Vilamajo, Xavier Suris Armangue, Dolors Grados, Chesus Beltran Audera, Evelyn Suero-Rosario, Inmaculada Gomez Gracia, Asuncion Salmoral Chamizo, Irene Martin-Esteve, Helena Florez, Antonio Naranjo, Santos Castaneda, Soledad Ojeda Bruno, Sara Garcia Carazo, Alberto Garcia-Vadillo, Laura Lopez Vives, Angels Martinez-Ferrert, Helena Borrell Panos, Pilar Aguado Acin, Raul Castellanos-Moreira, Pau Satorra, Cristian Tebe, Nuria Guanabens
Summary: The aim of this study was to estimate the incidence of clinical fragility fractures in postmenopausal women with rheumatoid arthritis (RA) and analyze the risk factors for fracture. The study found that the incidence of clinical fragility fractures in RA patients was higher compared to the control population. Risk factors for fractures in RA patients included age, previous fracture, parental hip fracture, years since menopause, bone mineral density, erosions, disease activity and disability, and cumulative dose of glucocorticoids. This highlights the higher risk of fractures in RA patients and the importance of addressing the associated risk factors.
Article
Rheumatology
Emilio Pariente, Stefanie F. Pini, Jose M. Olmos, Patricia Fierro, Rosa Landeras, Carmen Ramos, Victor M. Martinez-Taboada, Jose L. Hernandez
Summary: This study aimed to investigate the potential relationship between early diffuse idiopathic skeletal hyperostosis (DISH) and chronic inflammation. The results showed that patients with early DISH had a higher prevalence of obesity, type 2 diabetes, and metabolic syndrome, and their lipid pattern was similar to that observed in chronic inflammatory diseases.
CLINICAL RHEUMATOLOGY
(2023)
Article
Nutrition & Dietetics
Maria Perez-Alonso, Ismael Calero-Paniagua, Ricardo Usategui-Martin, Laisa-Socorro Briongos, Marta Ruiz-Mambrilla, Jose-Manuel Olmos, Manuel Gonzalez-Sagrado, Daniel De Luis, Antonio Duenas-Laita, Jose-Luis Perez-Castrillon
Summary: This study aimed to evaluate the possible additive effect of genistein supplementation on vitamin D levels, calcium metabolism, and bone remodeling markers. The results showed that adding genistein did not provide additional changes in vitamin D levels, calcium metabolism, or bone remodeling markers in healthy Spanish postmenopausal women.
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jose L. Hernandez, J. Gonzalo Ocejo-Vinyals, Monica Renuncio-Garcia, Elena Gonzalez-Lopez, Ricardo Blanco, Marcos A. Gonzalez-Lopez
Summary: This study investigates the role of serum ANGPTL2 levels in Hidradenitis suppurativa (HS) patients and controls. It is found that HS patients have higher serum ANGPTL2 levels compared to controls, and these levels are positively correlated with disease duration and severity. Therefore, ANGPTL2 may serve as a biomarker for HS severity.
Article
Immunology
Juan Irure-Ventura, Daniel Martinez-Revuelta, Marcos Lopez-Hoyos, Marta Martin-Millan, Daniel Nan, Emilio Pariente, Javier Pardo-Lledias, Alejandra Comins-Boo, Jose Manuel Olmos, Victor Manuel Martinez-Taboada, Jose Luis Hernandez
Summary: This study evaluates the relationship between antinuclear antibodies (ANA) and sociodemographic and biobehavioral factors. The results show that the prevalence of ANA is associated with gender, age, C-reactive protein levels, sedentary lifestyle, and alcohol use. These findings are important for a population with a low pre-test probability for systemic autoimmune diseases.
IMMUNOLOGIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jose A. Riancho, Jose L. Hernandez, Carmen Gonzalez-Vela, Ana E. Lopez-Sundh, Marcos A. Gonzalez-Lopez, Francisco Gomez de la Fuente, Remedios Quirce, Eli L. Diamond
Summary: This report presents a case of ECD in which a previously unidentified microduplication in the NRAS gene was discovered through deep sequencing of skin cells, leading to the development of a personalized therapeutic approach involving kinase inhibitors downstream of NRAS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Stefanie F. Pini, Emilio Pariente, Jose M. Olmos, Marta Martin-Millan, Raquel Pascua, Victor M. Martinez-Taboada, Jose L. Hernandez
Summary: This study aimed to assess the association between trabecular bone score (TBS) and diffuse idiopathic skeletal hyperostosis (DISH) in postmenopausal women. The results showed a significant association between DISH and TBS, with lower TBS values in DISH patients and a higher prevalence of osteoporosis and vertebral fractures.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)