Promising Markers of Inflammatory and Gut Dysbiosis in Patients with Post-COVID-19 Syndrome

Post-COVID-19 syndrome is a complex of different symptoms, which results in a multisystemic impairment after the suffering from COVID-19 infection. The aim of the study was to reveal the clinical, laboratory, and gut disorders in patients with post-COVID-19 syndrome (n = 39) before and after taking part in the 14-day complex program of rehabilitation. A complete blood count, coagulation test, blood chemistry, biomarkers, and metabolites in serum samples, and gut dysbiosis were revealed in patients on the day of admission and after 14-day rehabilitation, in comparison with the variables of healthy volunteers (n = 48) or with reference ranges. On the day of discharge, patients noted an improvement in respiratory function, general well-being, and mood. At the same time, the levels of some metabolic (4-hydroxybenzoic, succinic, fumaric acids) and inflammatory (interleukin-6) variables, which were increased on admission, did not reach the level of healthy people during the rehabilitation program. Taxonomy disbalance was observed in patients' feces, namely, a high level of total bacterial mass, a decrease in the number of Lactobacillus spp., and an increase in pro-inflammatory microorganisms. The authors suggest that the post-COVID-19 rehabilitation program should be personalized, considering the patient's state together with not only the baseline levels of biomarkers, but also with the individual taxonomy of the gut microbiota.

Automated summary

Post-COVID-19 syndrome is a complex condition that leads to impairment in multiple body systems after COVID-19 infection. A study examined the clinical, laboratory, and gut disorders in patients with post-COVID-19 syndrome before and after a 14-day rehabilitation program. The results showed improvements in respiratory function, general well-being, and mood, but some metabolic and inflammatory variables did not fully recover during the program. The study also found imbalances in the gut microbiota of patients. The authors suggest that personalized rehabilitation programs should consider not only biomarker levels, but also the individual taxonomy of the gut microbiota.