Privileged Biorenewable Secologanin‐Based Diversity‐Oriented Synthesis for Pseudo‐Natural Alkaloids: Uncovering Novel Neuroprotective and Antimalarial Frameworks

Pseudo Natural Products ‐ Chemical Evolution of Natural Product Structure

(2021) Herbert Waldmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isolation, Structure Elucidation, Semi-Synthesis, and Structural Modification of C19-Diterpenoid Alkaloids from Aconitum apetalum and Their Neuroprotective Activities

(2021) Lin-Xi Wan et al.   JOURNAL OF NATURAL PRODUCTS

Early and Late Steps of Quinine Biosynthesis

(2021) Francesco Trenti et al.   ORGANIC LETTERS

P450 variations bifurcate the early terpene indole alkaloid pathway in Catharanthus roseus and Camptotheca acuminata

(2021) Justin C. Miller et al.   PHYTOCHEMISTRY

Limonin as a Starting Point for the Construction of Compounds with High Scaffold Diversity

(2021) Lucia Furiassi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual Valorization of Lignin as a Versatile and Renewable Matrix for Enzyme Immobilization and (Flow) Bioprocess Engineering

(2021) Ana I. Benítez‐Mateos et al.   ChemSusChem

Diversity-oriented functionalization of 2-pyridones and uracils

(2021) Yong Shang et al.   Nature Communications

Inverted Binding of Non-natural Substrates in Strictosidine Synthase Leads to a Switch of Stereochemical Outcome in Enzyme-Catalyzed Pictet–Spengler Reactions

(2020) Elisabeth Eger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heterologous overexpression of Nothapodytes foetida strictosidine synthase enhances levels of anti-cancer compound camptothecin in Ophiorrhiza rugosa

(2020) Sudhir Singh et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Total Syntheses of (–)‐Strictosidine and Related Indole Alkaloid Glycosides

(2020) Hayato Ishikawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alkaloid and iridoid glucosides from Palicourea luxurians (Rubiaceae: Palicoureeae) indicate tryptamine- and tryptophan-iridoid alkaloid formation apart the strictosidine pathway

(2020) Christoph Kornpointner et al.   PHYTOCHEMISTRY

Bioinspired Divergent Oxidative Cyclization from Strictosidine and Vincoside Derivatives: Second Generation Total Synthesis of Cymoside and Access to an Original Hexacyclic‐Fused Furo[3,2‐b]indoline

(2020) Yingchao Dou et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Biocatalytic Synthesis of 1‐Aryltetrahydro‐β‐carbolines Enabled by ‘Substrate Walking’

(2020) Elisabeth Eger et al.   CHEMISTRY-A EUROPEAN JOURNAL

Directing-Group-Free, Carbonyl Group-Promoted Catalytic C–H Arylation of Bio-Based Furans

(2020) Bogdan Ya. Karlinskii et al.   ACS Catalysis

Bifunctional Cytochrome P450 Enzymes Involved in Camptothecin Biosynthesis

(2019) Yun Yang et al.   ACS Chemical Biology

Total Syntheses of (–)‐Secologanin, (–)‐5‐Carboxystrictosidine, and (–)‐Rubenine

(2019) Kenta Rakumitsu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

(2019) Evijola Llabani et al.   Nature Chemistry

Strategies for the Diversity-Oriented Synthesis of Macrocycles

(2019) Kim T. Mortensen et al.   CHEMICAL REVIEWS

Stereocomplementary Chemoenzymatic Pictet–Spengler Reactions for Formation of Rare Azepino-indole Frameworks: Discovery of Antimalarial Compounds

(2019) Yunrui Cai et al.   ACS Catalysis

Creating Diversity from Biomass: A Tandem Bio/Metal‐Catalysis towards Chemoselective Synthesis of Densely Substituted Furans

(2019) João M. J. M. Ravasco et al.   ChemSusChem

Enantioselective Total Synthesis of Cymoside through a Bioinspired Oxidative Cyclization of a Strictosidine Derivative

(2019) Yingchao Dou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Where Do Recent Small Molecule Clinical Development Candidates Come From?

(2018) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Computational Framework for the Identification of Bioprivileged Molecules

(2018) Xiaowei Zhou et al.   ACS Sustainable Chemistry & Engineering

Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

(2017) L. Huck et al.   GREEN CHEMISTRY

Bioprivileged molecules: creating value from biomass

(2017) Brent H. Shanks et al.   GREEN CHEMISTRY

Metabolite Diversity in Alkaloid Biosynthesis: A Multilane (Diastereomer) Highway for Camptothecin Synthesis in Camptotheca acuminata

(2016) Radin Sadre et al.   PLANT CELL

Cell-specific localization of alkaloids inCatharanthus roseusstem tissue measured with Imaging MS and Single-cell MS

(2016) Kotaro Yamamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Problem Solving and Environmentally Benign Approach toward Diversity Oriented Synthesis of Novel 2-Amino-3-phenyl (or Alkyl) Sulfonyl-4H-chromenes at Ambient Temperature

(2016) Kapil S. Pandit et al.   ACS Sustainable Chemistry & Engineering

Characterization of a second secologanin synthase isoform producing both secologanin and secoxyloganin allows enhanced de novo assembly of a Catharanthus roseus transcriptome

(2015) Thomas Dugé de Bernonville et al.   BMC GENOMICS

De novo production of the plant-derived alkaloid strictosidine in yeast

(2015) Stephanie Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stereoselective Cascade to C3-Methylated Strictosidine Derivatives Employing Transaminases and Strictosidine Synthases

(2015) Eva-Maria Fischereder et al.   ACS Catalysis

Pterin-Dependent Mono-oxidation for the Microbial Synthesis of a Modified Monoterpene Indole Alkaloid

(2015) A. M. Ehrenworth et al.   ACS Synthetic Biology

The seco-iridoid pathway from Catharanthus roseus

(2014) Karel Miettinen et al.   Nature Communications

A Chemical–Biological Study Reveals C9-type Iridoids as Novel Heat Shock Protein 90 (Hsp90) Inhibitors

(2013) Fabrizio Dal Piaz et al.   JOURNAL OF MEDICINAL CHEMISTRY

A 7-Deoxyloganetic Acid Glucosyltransferase Contributes a Key Step in Secologanin Biosynthesis in Madagascar Periwinkle

(2013) K. Asada et al.   PLANT CELL

A Pair of Tabersonine 16-Hydroxylases Initiates the Synthesis of Vindoline in an Organ-Dependent Manner in Catharanthus roseus

(2013) S. Besseau et al.   PLANT PHYSIOLOGY

Diversity-oriented synthesis: producing chemical tools for dissecting biology

(2012) Cornelius J. O' Connor et al.   CHEMICAL SOCIETY REVIEWS

An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis

(2012) Fernando Geu-Flores et al.   NATURE

Scaffold Tailoring by a Newly Detected Pictet–Spenglerase Activity of Strictosidine Synthase: From the Common Tryptoline Skeleton to the Rare Piperazino-indole Framework

(2011) Fangrui Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Impact of high-throughput screening in biomedical research

(2011) Ricardo Macarron et al.   NATURE REVIEWS DRUG DISCOVERY

A Facile Chemoenzymatic Approach: One-Step Syntheses of Monoterpenoid Indole Alkaloids

(2010) Hong-Bin Zou et al.   Chemistry-An Asian Journal

Three NewO-Methyltransferases Are Sufficient for AllO-Methylation Reactions of Ipecac Alkaloid Biosynthesis in Root Culture ofPsychotria ipecacuanha

(2010) Taiji Nomura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trends for diverse production strategies of plant medicinal alkaloids

(2010) Liuqing Yang et al.   NATURAL PRODUCT REPORTS

Integrating carbon–halogen bond formation into medicinal plant metabolism

(2010) Weerawat Runguphan et al.   NATURE

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

(2010) Warren R.J.D. Galloway et al.   Nature Communications

Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture

(2009) W. Runguphan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA