Review
Cell Biology
Ting Zhang, Qian Liu, Weihua Gao, Sheikh Arslan Sehgal, Hao Wu
Summary: Mitochondria play crucial roles in cellular metabolism and regulated cell death, with mitophagy serving as a key mechanism for maintaining cellular homeostasis. Mitophagy is regulated by various endogenous metabolites and is essential for the bidirectional interplay between mitophagy and cellular metabolisms.
Article
Environmental Sciences
Laura Camacho-Jimenez, Ricardo Gonzalez-Ruiz, Gloria Yepiz-Plascencia
Summary: This article summarizes the bioaccumulation and physiological effects of persistent organic pollutants (POPs) in marine crustaceans. The regulation of xenobiotic metabolism and antioxidant enzymes as key sub-cellular mechanisms for detoxification and protection are highlighted.
MARINE ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sufu Gan, Wilfried Rozhon, Elisabeth Varga, Jyotirmoy Halder, Franz Berthiller, Brigitte Poppenberger
Summary: This study reveals a new mechanism of acylation regulation in plants, with PMAT1 catalyzing the malonylation reaction of BL-23-O-Glc to regulate the activity of BRs. The findings highlight the role of PMAT1 in the regulation of both endogenous and xenobiotic glucosides in plants.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Xiaoyan Pang, Chongzhuang Tang, Runcong Guo, Xiaoyan Chen
Summary: This review focuses on the role of oxidative metabolism in regulating the exposure and effects of xenobiotics and their metabolites. It discusses the involvement of non-CYP450 enzymes in the metabolism of drugs and summarizes the common reaction mechanisms, factors affecting enzyme expression and activity, and species differences. The review highlights the potential impact of xenobiotic factors on the gene expression levels and activities of non-CYP450 enzymes.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Horticulture
Houkuan Huang, Mengting Ye, Xiale Cai, Shuhua Zhu, Lili Zhang
Summary: The synergistic effect of chitosan and sodium sulphate on energy metabolism and endogenous H2S metabolism of postharvest fruit was investigated. It was found that the synergistic treatment increased the activities of related enzymes and promoted the production of endogenous H2S in nectarine fruit. Additionally, the treatment also increased the activities of energy metabolism related enzymes and maintained a higher ATP and ADP content and energy level in the fruit.
SCIENTIA HORTICULTURAE
(2023)
Review
Biology
Mahmoud A. El-Ghiaty, Ayman O. S. El-Kadi
Summary: Arsenic is recognized as a hazardous element present in various environmental forms, requiring speciation to assess health risks. Exposure assessment and understanding arsenic's impact on human physiology are crucial for developing strategies to mitigate its toxicity. The role of cytochrome P450 enzymes in arsenic metabolism highlights the need to consider their effects on human health.
Article
Cell & Tissue Engineering
Ananya Nandy, Ron C. M. Helderman, Santosh Thapa, Shobana Jayapalan, Alison Richards, Nikita Narayani, Michael P. Czech, Clifford J. Rosen, Elizabeth Rendina-Ruedy
Summary: This study demonstrates that osteoblasts derive energy from endogenous fatty acids stored in lipid droplets via lipolysis, which is critical for bone formation. Fatty acids released by lipolysis become crucial for cellular energy production under nutrient-depleted conditions. Perturbations in this process result in impairment of bone formation.
Article
Medicine, Research & Experimental
O. S. Bryushinina, Yu G. Zyuz'kova, E. A. Yanovskaya, N. Y. Abdrashitova, G. A. Frelikh, A. P. Lakeev, D. Tsuran, V. V. Udut, G. N. Zyuz'kov
Summary: The study focused on the role of JNK in regulating the metabolism of xenobiotic venlafaxine by liver cells in vitro, showing its inhibitory effect on the biotransformation of the psychotropic agent. Adding a JNK inhibitor to a liver homogenate containing the antidepressant led to enhanced and accelerated formation of the active metabolite. These results suggest the potential of studying intracellular signaling molecules to develop a novel approach for controlling xenobiotic transformation and creating pharmaceutical regulators of drug metabolism.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Dong Gui Hu, Peter I. Mackenzie, Julie-Ann Hulin, Ross A. McKinnon, Robyn Meech
Summary: The human UGT gene superfamily encodes 22 functional enzymes, which are critical for the metabolism and clearance of various compounds. MiRNAs have been found to be important post-transcriptional regulators of the UGT gene superfamily, with 14 UGT genes regulated by specific miRNAs through binding to their respective 3' UTRs. This article reviews the reported UGT/miRNA regulation studies, discusses the impact of polymorphisms within functional miRNA target sites, and explores potential cooperative and competitive regulation of UGT genes by adjacently located miRNA target sites.
DRUG METABOLISM REVIEWS
(2022)
Article
Chemistry, Medicinal
Rong-Jing He, Zhen-Hao Tian, Jian Huang, Meng-Ru Sun, Feng Wei, Chun-Yu Li, Hai-Rong Zeng, Feng Zhang, Xiao-Qing Guan, Yan Feng, Xiang-Ming Meng, Hui Yang, Guang-Bo Ge
Summary: In this study, a rational strategy was used to construct a practical two-photon fluorogenic substrate for hCYP3A4. The developed hCYP3A4 fluorogenic substrate (F8) showed high binding affinity, rapid response, excellent isoform specificity, and low cytotoxicity. F8 was successfully used for real-time sensing, functional imaging, high-throughput screening of hCYP3A4 inhibitors, and assessing drug-drug interaction potentials in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Francisco Saez-Orellana, Thomas Leroy, Floriane Ribeiro, Anna Kreis, Karelle Leroy, Fanny Lalloyer, Eric Bauge, Bart Staels, Charles Duyckaerts, Jean-Pierre Brion, Philippe Gailly, Jean-Noel Octave, Nathalie Pierrot
Summary: This study found a possible correlation between lipid metabolism and the onset of Alzheimer's disease. Activation of PPAR alpha showed improvement in synaptic plasticity in AD cases and was inversely related to APP expression. The association was reversed in the case of APP silencing, indicating the key role of PPAR alpha in synaptic activity control.
Article
Biochemistry & Molecular Biology
Vikas D. Trivedi, Sean F. Sullivan, Debika Choudhury, Venkatesh Endalur Gopinarayanan, Taylor Hart, Nikhil U. Nair
Summary: Engineering synthetic heterotrophy is crucial for efficient utilization of renewable and waste substrates. The utilization of hemicellulosic pentose in yeast remains challenging. By harmonizing cellular and engineering objectives, highest growth rates and yields can be achieved with minimal metabolic engineering effort. Upstream genes directing pentose flux into central carbon metabolism are identified as rate-limiting factors. Moreover, yeast metabolism shows high adaptability to non-native substrates, making extensive systems metabolic engineering unnecessary.
CELL CHEMICAL BIOLOGY
(2023)
Review
Genetics & Heredity
Olga V. Balberova, Evgeny V. Bykov, German V. Medvedev, Margarita A. Zhogina, Kirill V. Petrov, Marina M. Petrova, Mustafa Al-Zamil, Vera V. Trefilova, Polina S. Goncharova, Natalia A. Shnayder
Summary: Genetic variations play a significant role in influencing athletic performance through energy metabolism regulation in skeletal muscles. Identifying genetic markers associated with energy metabolism regulation can help develop personalized strategies for selecting athletes in endurance, strength, and speed sports, ultimately improving performance and reducing the risk of sports injuries.
Article
Medicine, Research & Experimental
Gaelle Magliocco, Jules Desmeules, Caroline Flora Samer, Aurelien Thomas, Youssef Daali
Summary: The suitability of endogenous 6-hydroxymelatonin/melatonin urinary metabolic ratio as a surrogate for cytochrome P450 1A2 (CYP1A2) activity was assessed, and it was found that there is a significant linear relationship between this ratio and first morning voids. However, the variability of the endogenous ratio is larger than the paraxanthine/caffeine ratio, which questions its adequacy as a substitute for CYP1A2 activity. Additional studies with larger samples are needed to further examine this endogenous metric.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Chemistry, Applied
Gleb Nikolaevich Zyuz'kov, Olga Sergeevna Bryushinina, Yuliya Genad'evna Zyuz'kova, Alexander Pavlovich Lakeev, Natalia Yur'evna Abdrashitova, Galina Andreevna Frelikh, Daria Vladimirovna Tsuran, Elena Anatol'evna Yanovskaya, Vladimir Vasil'evich Udut
Summary: The management of drug metabolism is crucial for personalized pharmacotherapy. This research explored the possibility of controlling the biotransformation of substances in the body through targeted regulation of intracellular signal transduction. The results showed that JNK inhibitors can significantly induce the metabolism of venlafaxine, providing a new approach for the characterization of antidepressant treatment and the development of targeted drug metabolism regulators.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)
Article
Toxicology
Eva Novotna, Neslihan Bukum, Jakub Hofman, Michaela Flaxova, Etela Kouklikova, Dagmar Louvarova, Vladimir Wsol
ARCHIVES OF TOXICOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Lucie Zemanova, Hana Navratilova, Rudolf Andrys, Kristyna Sperkova, Jiri Andrejs, Klara Kozakova, Marc Meier, Gabriele Moeller, Eva Novotna, Miroslav Safr, Jerzy Adamski, Vladimir Wsol
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2019)
Article
Pharmacology & Pharmacy
Eva Novotna, Neslihan Bukum, Jakub Hofman, Michaela Flaxova, Etela Kouklikova, Dagmar Louvarova, Vladimir Wsol
BIOCHEMICAL PHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Ales Sorf, Eva Novotna, Jakub Hofman, Anselm Morell, Frantisek Staud, Vladimir Wsol, Martina Ceckova
BIOCHEMICAL PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Neslihan Bukum, Eva Novotna, Anselm Morell, Jakub Hofman, Vladimir Wsol
CHEMICO-BIOLOGICAL INTERACTIONS
(2019)
Article
Toxicology
Eva Novotna, Anselm Morell, Neslihan Bukum, Jakub Hofman, Petra Danielisova, Vladimir Wsol
ARCHIVES OF TOXICOLOGY
(2020)
Article
Oncology
Ales Sorf, Simona Sucha, Anselm Morell, Eva Novotna, Frantisek Staud, Alzbeta Zavrelova, Benjamin Visek, Vladimir Wsol, Martina Ceckova
Article
Toxicology
Anselm Morell, Eva Novotna, Jaroslav Milan, Petra Danielisova, Neslihan Bukum, Vladimir Wsol
Summary: Midostaurin, an FLT3 inhibitor, shows therapeutic benefit beyond FLT3 inhibition in treating AML by blocking AKR1C3-mediated inactivation of Dau, increasing cellular accumulation of Dau, and enhancing its cytotoxic effects.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Oncology
Tassia S. Tavares, Jakub Hofman, Alzbeta Lekesova, Jana Zelazkova, Vladimir Wsol
Article
Oncology
Anselm Morell, Lucie Cermakova, Eva Novotna, Lenka Lastovickova, Melodie Haddad, Andrew Haddad, Ramon Portillo, Vladimir Wsol
Article
Pharmacology & Pharmacy
Lucie Cermakova, Jakub Hofman, Lenka Lastovickova, Lucie Havlickova, Ivona Springrova, Eva Novotna, Vladimir Wsol
Summary: This study demonstrates that the Bruton's tyrosine kinase inhibitor Zanubrutinib can counteract anthracycline (ANT) drug resistance by targeting aldo-keto reductase 1C3 (AKR1C3) and ATP-binding cassette (ABC) transporters. Zanubrutinib inhibits AKR1C3-mediated inactivation of daunorubicin (DAUN) and interferes with the efflux of DAUN mediated by ABC transporters. These findings provide a rationale for including Zanubrutinib in ANT-based therapy and suggest its potential for treating tumors expressing AKR1C3 and/or ABC transporters.
Meeting Abstract
Toxicology
N. Bukum, V. Wsol, E. Novotna
TOXICOLOGY LETTERS
(2019)
Article
Biochemistry & Molecular Biology
Petra Malatkova, Adam Skarka, Katerina Musilova, Vladimir Wsol
CHEMICO-BIOLOGICAL INTERACTIONS
(2017)
Article
Chemistry, Medicinal
Eva Novotna, Karel Waisser, Jiri Kunes, Karel Palat, Lenka Skalova, Barbora Szotakova, Vladimir Buchta, Jirina Stolarikova, Vit Ulmann, Marcela Pavova, Jan Weber, Jitka Komrskova, Pavlina Haskova, Ivan Vokral, Vladimir Wsol
ARCHIV DER PHARMAZIE
(2017)
Review
Neurosciences
Ondrej Soukup, Michael Winder, Uday Kumar Killi, Vladimir Wsol, Daniel Jun, Kamil Kuca, Gunnar Tobin
CURRENT NEUROPHARMACOLOGY
(2017)