Article
Multidisciplinary Sciences
Andreas Hessler, Sophia Wahl, Till Leuteritz, Antonios Antonopoulos, Christina Stergianou, Carl-Friedrich Schoen, Lukas Naumann, Niklas Eicker, Martin Lewin, Tobias W. W. Mass, Matthias Wuttig, Stefan Linden, Thomas Taubner
Summary: The authors introduce In3SbTe2 (IST) as a programmable material platform for plasmonics and nanophotonics in the infrared. They demonstrate direct optical writing, modifying and erasing of metallic crystalline IST nanoantennas, tuning their resonances, as well as nanoscale screening and soldering.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Laura Sutarlie, Heng Li Chee, Sian Yang Ow, Zainul Aabdin, Weng Weei Tjiu, Xiaodi Su
Summary: In this study, a rapid method for counting total bacterial cells was developed using gold nanoparticles conjugated with affinity ligands to stain bacteria captured on a filter membrane. The method showed high sensitivity and a short turnover time, making it suitable for on-site applications.
Article
Chemistry, Multidisciplinary
Laura Sutarlie, Heng Li Chee, Sian Yang Ow, Zainul Aabdin, Weng Weei Tjiu, Xiaodi Su
Summary: A rapid total bacterial count method based on gold nanoparticles conjugated with affinity ligands was developed. The method showed high sensitivity and fast response time, making it suitable for on-site applications.
Article
Engineering, Biomedical
Pragati K. Prasad, Noa Eizenshtadt, Inna Goliand, Liat Fellus-Alyagor, Roni Oren, Ofra Golani, Leila Motiei, David Margulies
Summary: Fluorescent probes based on chemically modified bacteria can effectively label overexpressed cell surface proteins in cancer cells and tissues. The probes are simple to prepare and modify, and can label different types of cancer cells with bright colors. The internalization of the probes can be utilized for therapy or inhibitor screening.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Multidisciplinary
Priyanka Yadav, Abhineet Verma, Vishal Prasad Sharma, Rashmi Singh, Tarun Yadav, Ranjeet Kumar, Shiv Pal, Hariom Gupta, Satyen Saha, Ashish K. Tewari
Summary: Fluorescent solid-state pyridazinone-based homo- and heterodimers with intramolecular stacking exhibit suitable emission spectra and charge transfer properties. The optical behavior of these compounds was studied using time-dependent density functional theory, and their significance in the design of solid-state organic fluorescent materials was demonstrated.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ruo-Can Qian, Ze-Rui Zhou, Weijie Guo, Yuting Wu, Zhenglin Yang, Yi Lu
Summary: The strategy based on DNAzymes allows for controllable cell-cell interactions triggered by metal ions, effectively manipulating cell behaviors such as cell-cell conjunctions and disaggregation. This method has been successfully applied to control assembly and disassembly between two cell spheroids.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Nanoscience & Nanotechnology
Zhaojun Jia, Kern Hast, Enver Cagri Izgu
Summary: This study presents a new chemical approach for simple and site-specific surface functionalization, enabling drop-coating and grafting of solid surfaces in a single operation using small volumes. The method shows general applicability for immobilizing molecules of diverse structure and biological activities, with demonstrated biological applications in anti-biofouling, cellular adhesion, scaffold seeding, and tissue regeneration, advancing surface chemistry by integrating simplicity and precision with multipurpose surface functionalization.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Applied
Patricia Cazon, Manuel Vazquez
Summary: Food packaging plays a crucial role in food preservation and minimizing waste, but the high consumption of non-biodegradable materials has led to challenges in waste management. The search for biodegradable alternatives, such as bacterial cellulose, with unique properties, is gaining interest in the food packaging industry.
FOOD HYDROCOLLOIDS
(2021)
Article
Biotechnology & Applied Microbiology
Dariusz Abramczyk, Maria del Carmen Sanchez Olmos, Adan Andres Ramirez Rojas, Daniel Schindler, Daniel Robertson, Stephen McColm, Adele L. Marston, Paul N. Barlow
Summary: A linear nanochromosome has been developed in K. phaffii, allowing for stable integration of multiple foreign genes and potentially facilitating cost-effective biomanufacturing.
MICROBIAL CELL FACTORIES
(2023)
Review
Biochemistry & Molecular Biology
Silvia Vieira, Joana Silva-Correia, Rui L. Reis, J. Miguel Oliveira
Summary: Hydrogels are versatile platforms in tissue engineering with a wide range of applications. Their properties can be tuned through various methods, making them valuable for drug and cell-based therapies as well as fundamental research. The diversity in sources, crosslinking strategies, functionalization methods, and similarity to the extracellular matrix make hydrogels an excellent tool in tissue engineering. This review provides an overview of hydrogel design, processing methods, and the impact of different formulations on cell-biomaterial interactions.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Teresa Aditya, Jean Paul Allain, Camilo Jaramillo, Andrea Mesa Restrepo
Summary: Bacterial cellulose is a naturally occurring polysaccharide with various biomedical applications. It possesses remarkable biocompatibility and mechanical properties, making it suitable for tissue replacement. This review discusses the structure, mechanical properties, and characterization techniques of bacterial cellulose. It also explores the functionalization and surface modification methods to enhance its functionality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Ryan S. Czarny, Alexander N. Ho, P. Shing Ho
Summary: Classical hydrogen bonds have long been the main non-covalent interaction used by chemists and chemical engineers to design and control compound structures, but recently non-classical non-covalent interactions such as halogen bonds have also emerged as important tools. Research is focused on understanding the role of halogen bonds in biological systems and utilizing them to control the structures, stabilities, and activities of biomolecules.
Review
Chemistry, Multidisciplinary
Jun Guan, Jeong-Eun Park, Shikai Deng, Max J. H. Tan, Jingtian Hu, Teri W. Odom
Summary: This review discusses the integration of plasmonic and dielectric metasurfaces with emissive or stimuli-responsive materials, enabling control of light-matter interactions at the nanoscale. Metasurfaces offer the ability to manipulate electromagnetic waves at the subwavelength level, while the combination with nanoscale emitters allows for enhanced photoluminescence, nanoscale lasing, controlled quantum emission, and formation of exciton-polaritons. Additionally, the use of functional materials that respond to external stimuli enables the engineering of tunable nanophotonic devices. Emerging metasurface designs, such as surface-functionalized, chemically tunable, and multilayer hybrid metasurfaces, hold promise for various applications including photocatalysis, sensing, displays, and quantum information.
Review
Chemistry, Multidisciplinary
Devleena Samanta, Wenjie Zhou, Sasha B. Ebrahimi, Sarah Hurst Petrosko, Chad A. Mirkin
Summary: Colloidal crystal engineering with DNA has made significant advances in bottom-up materials synthesis and fundamental concepts in chemistry, allowing the independent tuning of nanoparticle characteristics and DNA properties to create designer materials with unique properties.
ADVANCED MATERIALS
(2022)
Article
Multidisciplinary Sciences
Fiona Whelan, Aleix Lafita, James Gilburt, Clement Degut, Samuel C. Griffiths, Huw T. Jenkins, Alexander N. St John, Emanuele Paci, James W. B. Moir, Michael J. Plevin, Christoph G. Baumann, Alex Bateman, Jennifer R. Potts
Summary: Changes at the cell surface enable bacteria to survive in dynamic environments, with Periscope Proteins identified as a common mechanism for bacterial surface alteration through protein length variation. These proteins, forming elongated rod-like structures, can have over 50 distinct variants implicated in host colonization and biofilm formation. While sequence divergence in large multidomain proteins may reduce misfolding between domains, Periscope Proteins break this rule and suggest that their length variability is crucial in regulating bacterial interactions with host surfaces and the immune system.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Analytical
Isaac N. Larkin, Viswanadham Garimella, Gokay Yamankurt, Alexander W. Scott, Hang Xing, Chad A. Mirkin
ANALYTICAL CHEMISTRY
(2020)
Review
Chemistry, Multidisciplinary
Dan Zhao, Yuhan Kong, Sisi Zhao, Hang Xing
TOPICS IN CURRENT CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Minjie Lin, Yuanyuan Chen, Sisi Zhao, Rui Tang, Zhou Nie, Hang Xing
Summary: By utilizing liposome fusion-based transport, functional DNA can be applied to both external and internal cell surfaces, expanding the applications of cell engineering. This approach allows for efficient and spatially controlled engineering of cell membranes, enabling the construction of anisotropic membrane structures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Huangchen Cui, Tianqing Zhang, Yuhan Kong, Hang Xing, Bryan Wei
Summary: This article presents a programmable ternary interaction strategy based on the natural DNA triplex structure, demonstrating controllable hierarchical assemblies and selective signaling system. It enriches the design schemes of DNA nanotechnology.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Yingjiao Deng, Tong Wu, Xianhui Chen, Yuanyuan Chen, Yating Fei, Ying Liu, Zhiyong Chen, Hang Xing, Yugang Bai
Summary: This study presents a synthetic enzyme mimic based on a cationic dense-shell nanoparticle scaffold that demonstrates substrate selectivity in living cells. The nanoparticle exhibits excellent membrane affinity, enabling efficient on-membrane synthesis. Importantly, the catalyst retains its selectivity towards lipophilic and anionic substrates and successfully transports them into eukaryotic cells.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Lin Shen, Yuanyuan Wu, Wenxue Xie, Guangyao Chen, Hang Xing
Summary: Antibody-oligonucleotide conjugates (AOCs) are important tools for drug development and biochemical analysis. Different covalent coupling approaches, categorized as linker-free or linker-mediated, have been developed to synthesize AOCs with precise site-specificity and degree of conjugation. Factors such as site-specificity, conjugation control, accessibility, stability, and efficiency are highlighted when evaluating the pros and cons of these approaches. The future of AOCs includes the development of better conjugation approaches for stimuli-responsive release and the application of high-throughput methods to facilitate their development.
Article
Chemistry, Multidisciplinary
Wenxian Zhang, Ran Liu, Yang Shi, Hang Xing, Jingjing Zhang
Summary: Due to the global spread of COVID-19, education has shifted to distance online learning, but some face-to-face courses have resumed, including a laboratory course for senior undergraduate students in chemical biology. This article presents an innovative chemical biology experiment on COVID-19 for third-year undergraduates, demonstrating the principles of two diagnostic techniques for SARS-CoV-2. The experiments ensure biosafety using artificial nucleic acids and recombinant protein, and an interactive online teaching model covers key mechanisms of COVID-19 testing. The course received a satisfactory evaluation and suggestions for improvement.
JOURNAL OF CHEMICAL EDUCATION
(2023)
Article
Multidisciplinary Sciences
Yuanyuan Chen, Tong Wu, Shasha Xie, Yugang Bai, Hang Xing
Summary: The sensitivity of artificial metal catalysts presents an obstacle to conducting diverse bioorthogonal reactions in living systems. In this study, we propose a strategy called membrane-anchored catalysts with precise spatial control via liposome fusion-based transport (MAC-LiFT) to address this issue. By loading bioorthogonal catalytic complexes onto the membrane leaflets, we found that the inner face of the cytoplasmic membrane can effectively protect the complexes from deactivation, significantly reducing the amount of catalyst needed for intracellular catalysis. The MAC-LiFT approach enables the establishment of catalyst-protective systems using exclusively exogenous agents in a wide range of mammalian cells, facilitating the convenient and broader use of diverse bioorthogonal reactions in live cellular systems.
Article
Multidisciplinary Sciences
Lizhi Dai, Xiaoxue Hu, Min Ji, Ningning Ma, Hang Xing, Jun- Jie Zhu, Qianhao Min, Ye Tian
Summary: Harnessing the programmable nature of DNA origami, researchers have demonstrated the ability to control structural features in crystalline materials and achieve different equilibrium phases and shapes using a single DNA origami morphology. By modulating the binding coordination with an allosteric factor, the DNA origami crystals undergo phase transitions and yield diverse crystal systems. This approach opens up new possibilities for developing crystalline materials with tunable properties and accessing a rich phase space.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Yu Liang, Xiaoxin Yang, Xiaoyu Wang, Zong-Jie Guan, Hang Xing, Yu Fang
Summary: Functionalizing porous materials is a way to enhance the properties of hybrid materials. In this study, a Cage-on-MOF strategy was used to modify the surface of mesoporous MOFs using molecular cages, achieving selective dye adsorption behavior and heterogeneous catalysis.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Ying Liu, Zhongwu Ren, Nannan Zhang, Xiaoxin Yang, Qihua Wu, Zehong Cheng, Hang Xing, Yugang Bai
Summary: Synthetic polypeptides are versatile materials in materials science and biomedical engineering. Researchers have developed a method using nanoscale metal-organic frameworks as co-catalysts to accelerate N-carboxyanhydride (NCA) ring-opening polymerization (ROP) reactions, aided by peptide helices. This approach offers advantages such as fast kinetics, low environment sensitivity, catalyst recyclability, and seamless integration with hybrid materials preparation.
NATURE COMMUNICATIONS
(2023)
Review
Multidisciplinary Sciences
Zhongwu Ren, Nannan Zhang, Yuanyuan Wu, Xue Ding, Xiaoxin Yang, Yuhan Kong, Hang Xing
Summary: This article introduces the assembly methods of metal-organic frameworks (MOFs) and their impact on material properties, including the study of building blocks, surface interactions, and Gibbs free energy. The macroscopic structures formed by facet-controlled assembly of individual particles have improved overall properties while maintaining individual particle characteristics.
Article
Chemistry, Multidisciplinary
Ran Liu, Zheng Liu, Mohan Chen, Hang Xing, Penghui Zhang, Jingjing Zhang
Summary: This study reports a new archetype of PROTAC (PS-ApTCs) that can selectively degrade NSPs by introducing an aptamer to a CRBN ligand. PS-ApTCs effectively degrade nucleolin in the cell membrane and cytoplasm, while avoiding degradation in the nucleus. Furthermore, PS-ApTCs exhibits superior antitumor activity and synergistic effects with aptamer-drug conjugate-based chemotherapy.
Article
Chemistry, Multidisciplinary
Jing Yan, Ya-Ling Tan, Min-jie Lin, Hang Xing, Jian-Hui Jiang
Summary: The crosslinking strategy improved the delivery efficiency and intracellular sensor performance of ProSNA, with X-SNA showing significantly enhanced sensor performance with a 4 times higher signal-to-noise ratio when detecting intracellular lactate.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)