Engineering Functional DNA–Protein Conjugates for Biosensing, Biomedical, and Nanoassembly Applications

Predictive Multivariate Models for Bioorthogonal Inverse-Electron Demand Diels–Alder Reactions

(2020) Joao M. J. M. Ravasco et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Correction to Tunable Nanoscale Cages from Self-Assembling DNA and Protein Building Blocks

(2020) Yang Xu et al.   ACS Nano

Construction of DNA-NanoLuc luciferase conjugates for DNA aptamer-based sandwich assay using Rep protein

(2019) Masayasu Mie et al.   BIOTECHNOLOGY LETTERS

Aptamer-Structure Switch Coupled with Horseradish Peroxidase Labeling on a Microplate for the Sensitive Detection of Small Molecules

(2019) Yapiao Li et al.   ANALYTICAL CHEMISTRY

DNA origami as scaffolds for self‐assembly of lipids and proteins

(2019) Yuanchen Dong et al.   CHEMBIOCHEM

Protein Materials Engineering with DNA

(2019) Janet R. McMillan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Rotation tracking of genome-processing enzymes using DNA origami rotors

(2019) Pallav Kosuri et al.   NATURE

Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues

(2019) Sinem K. Saka et al.   NATURE BIOTECHNOLOGY

Profiling surface proteins on individual exosomes using a proximity barcoding assay

(2019) Di Wu et al.   Nature Communications

Biocomputing for Portable, Resettable, and Quantitative Point-of-Care Diagnostics: Making the Glucose Meter a Logic-Gate Responsive Device for Measuring Many Clinically Relevant Targets

(2018) Jingjing Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid Electrochemical Assessment of Tumor Suppressor Gene Methylations in Raw Human Serum and Tumor Cells and Tissues Using Immunomagnetic Beads and Selective DNA Hybridization

(2018) Eloy Povedano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Folding DNA into a Lipid-Conjugated Nanobarrel for Controlled Reconstitution of Membrane Proteins

(2018) Yuanchen Dong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-specific cross-linking of proteins to DNA via a new bioorthogonal approach employing oxime ligation

(2018) Suresh S. Pujari et al.   CHEMICAL COMMUNICATIONS

Nanomaterial-based devices for point-of-care diagnostic applications

(2018) Daniel Quesada-González et al.   CHEMICAL SOCIETY REVIEWS

DNA-Functionalized, Bivalent Proteins

(2018) Janet R. McMillan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA-Encoded Protein Janus Nanoparticles

(2018) Oliver G. Hayes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

(2018) Suping Li et al.   NATURE BIOTECHNOLOGY

Translating molecular detections into a simple temperature test using a target-responsive smart thermometer

(2018) Jingjing Zhang et al.   Chemical Science

An exploration of nucleic acid liquid biopsy using a glucose meter

(2018) Yu Gu et al.   Chemical Science

DNA Nanostructures at the Interface with Biology

(2018) Katherine E. Bujold et al.   Chem

DNA-Mediated Proximity-Based Assembly Circuit for Actuation of Biochemical Reactions

(2018) Sung Won Oh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and synthesis of ortho-phthalaldehyde phosphoramidite for single-step, rapid, efficient and chemoselective coupling of DNA with proteins under physiological conditions

(2018) Yanli Ma et al.   CHEMICAL COMMUNICATIONS

Visual and modular detection of pathogen nucleic acids with enzyme–DNA molecular complexes

(2018) Nicholas R. Y. Ho et al.   Nature Communications

Programming Protein Polymerization with DNA

(2018) Janet R. McMillan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Nanotube Selectively Cleavable with DNA: Supramolecular Polymerization of “DNA-Appended Molecular Chaperones”

(2017) Daiki Kashiwagi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modulating Nanoparticle Superlattice Structure Using Proteins with Tunable Bond Distributions

(2017) Janet R. McMillan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzyme-functionalized DNA nanostructures as tools for organizing and controlling enzymatic reactions

(2017) Guido Grossi et al.   MRS BULLETIN

An efficient enzyme-powered micromotor device fabricated by cyclic alternate hybridization assembly for DNA detection

(2017) Shizhe Fu et al.   Nanoscale

Self-assembly of genetically encoded DNA-protein hybrid nanoscale shapes

(2017) Florian Praetorius et al.   SCIENCE

An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells

(2017) Gang Li et al.   Nature Communications

Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactions

(2017) Andreas Sprengel et al.   Nature Communications

Control of enzyme reactions by a reconfigurable DNA nanovault

(2017) Guido Grossi et al.   Nature Communications

Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair

(2017) Kunwoo Lee et al.   Nature Biomedical Engineering

Streptavidin-triggered signal amplified fluorescence polarization for analysis of DNA–protein interactions

(2016) Jae-Won Choi et al.   ANALYST

Multimodal Detection of a Small Molecule Target Using Stimuli-Responsive Liposome Triggered by Aptamer–Enzyme Conjugate

(2016) Hang Xing et al.   ANALYTICAL CHEMISTRY

Directional Regulation of Enzyme Pathways through the Control of Substrate Channeling on a DNA Origami Scaffold

(2016) Guoliang Ke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient Formation of Site-Specific Protein–DNA Hybrids Using Copper-Free Click Chemistry

(2016) Ann Mukhortava et al.   BIOCONJUGATE CHEMISTRY

Cellular delivery of enzyme-loaded DNA origami

(2016) Ari Ora et al.   CHEMICAL COMMUNICATIONS

Antibodies and antibody-derived analytical biosensors

(2016) S. Sharma et al.   Essays in Biochemistry

Design of a molecular support for cryo-EM structure determination

(2016) Thomas G. Martin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using modified aptamers for site specific protein–aptamer conjugations

(2016) Ruowen Wang et al.   Chemical Science

Genetic encoding of DNA nanostructures and their self-assembly in living bacteria

(2016) Johann Elbaz et al.   Nature Communications

Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion

(2016) Zhao Zhao et al.   Nature Communications

A covalent and cleavable antibody-DNA conjugation strategy for sensitive protein detection via immuno-PCR

(2016) Jessie A. G. L. van Buggenum et al.   Scientific Reports

Integration of Solution-Based Assays onto Lateral Flow Device for One-Step Quantitative Point-of-Care Diagnostics Using Personal Glucose Meter

(2016) JingJing Zhang et al.   ACS Sensors

Highly sensitive ligand-binding assays in pre-clinical and clinical applications: immuno-PCR and other emerging techniques

(2015) Mark Spengler et al.   ANALYST

Portable Detection of Melamine in Milk Using a Personal Glucose Meter Based on an in Vitro Selected Structure-Switching Aptamer

(2015) Chunmei Gu et al.   ANALYTICAL CHEMISTRY

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing

(2015) Wujin Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A modular DNA origami-based enzyme cascade nanoreactor

(2015) Veikko Linko et al.   CHEMICAL COMMUNICATIONS

Using a Personal Glucose Meter and Alkaline Phosphatase for Point-of-Care Quantification of Galactose-1-Phosphate Uridyltransferase in Clinical Galactosemia Diagnosis

(2015) Jingjing Zhang et al.   Chemistry-An Asian Journal

DNA-Mediated Cellular Delivery of Functional Enzymes

(2015) Jeffrey D. Brodin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA-mediated engineering of multicomponent enzyme crystals

(2015) Jeffrey D. Brodin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Constructing real-time, wash-free, and reiterative sensors for cell surface proteins using binding-induced dynamic DNA assembly

(2015) Yanan Tang et al.   Chemical Science

Proximity-dependent initiation of hybridization chain reaction

(2015) Björn Koos et al.   Nature Communications

Tuning Enzyme Kinetics through Designed Intermolecular Interactions Far from the Active Site

(2015) Yingning Gao et al.   ACS Catalysis

Inverse Electron-Demand Diels–Alder Bioorthogonal Reactions

(2015) Haoxing Wu et al.   Topics in Current Chemistry

Simple and Efficient Method to Purify DNA–Protein Conjugates and Its Sensing Applications

(2014) Zhaojuan Zhou et al.   ANALYTICAL CHEMISTRY

A DNA-Mediated Homogeneous Binding Assay for Proteins and Small Molecules

(2014) Zhao Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Virus-Encapsulated DNA Origami Nanostructures for Cellular Delivery

(2014) Joona Mikkilä et al.   NANO LETTERS

Diels-Alder reaction–triggered bioorthogonal protein decaging in living cells

(2014) Jie Li et al.   Nature Chemical Biology

Binding-Induced Formation of DNA Three-Way Junctions and Its Application to Protein Detection and DNA Strand Displacement

(2013) Feng Li et al.   ANALYTICAL CHEMISTRY

Bioorthogonal chemistry: strategies and recent developments

(2013) Carlo P. Ramil et al.   CHEMICAL COMMUNICATIONS

Nano-Encrypted Morse Code: A Versatile Approach to Programmable and Reversible Nanoscale Assembly and Disassembly

(2013) Ngo Yin Wong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates

(2013) C. H. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A DNA tweezer-actuated enzyme nanoreactor

(2013) Minghui Liu et al.   Nature Communications

Detection of Antigens Using a Protein–DNA Chimera Developed by Enzymatic Covalent Bonding with phiX Gene A*

(2012) Farhima Akter et al.   ANALYTICAL CHEMISTRY

Using Commercially Available Personal Glucose Meters for Portable Quantification of DNA

(2012) Yu Xiang et al.   ANALYTICAL CHEMISTRY

Enhancement and Modulation of Enzymatic Activity through Higher-Order Structural Changes of Giant DNA-Protein Multibranch Conjugates

(2012) Sergii Rudiuk et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme-based ultrasensitive electrochemical biosensors

(2012) Haesik Yang   CURRENT OPINION IN CHEMICAL BIOLOGY

Interenzyme Substrate Diffusion for an Enzyme Cascade Organized on Spatially Addressable DNA Nanostructures

(2012) Jinglin Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-specific DNA-antibody conjugates for specific and sensitive immuno-PCR

(2012) S. A. Kazane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

(2012) S. M. Douglas et al.   SCIENCE

Photon-Regulated DNA-Enzymatic Nanostructures by Molecular Assembly

(2011) Mingxu You et al.   ACS Nano

Binding-Induced DNA Assembly and Its Application to Yoctomole Detection of Proteins

(2011) Hongquan Zhang et al.   ANALYTICAL CHEMISTRY

High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number

(2011) Benjamin J. Hindson et al.   ANALYTICAL CHEMISTRY

DNA-Templated Protein Arrays for Single-Molecule Imaging

(2011) Daniele N. Selmi et al.   NANO LETTERS

Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets

(2011) Yu Xiang et al.   Nature Chemistry

Nanoparticle Superlattice Engineering with DNA

(2011) R. J. Macfarlane et al.   SCIENCE

Orthogonal Protein Decoration of DNA Nanostructures

(2011) Rebecca Meyer et al.   Small

Site-Specific Attachment of Proteins onto a 3D DNA Tetrahedron through Backbone-Modified Phosphorothioate DNA

(2011) Ngo Yin Wong et al.   Small

Immuno-PCR: a promising ultrasensitive diagnostic method to detect antigens and antibodies

(2011) Nada Malou et al.   TRENDS IN MICROBIOLOGY

Semisynthetic DNA-Protein Conjugates for Biosensing and Nanofabrication

(2010) Christof M. Niemeyer   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Aptamer Cross-Linked Hydrogel as a Colorimetric Platform for Visual Detection

(2010) Zhi Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlled Alignment of Multiple Proteins and Nanoparticles with Nanometer Resolution via Backbone-Modified Phosphorothioate DNA and Bifunctional Linkers

(2010) Jung Heon Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A highly sensitive immuno-PCR assay for detection of H5N1 avian influenza virus

(2010) Ming Jun Deng et al.   MOLECULAR BIOLOGY REPORTS

DNA-controlled assembly of a NaTl lattice structure from gold nanoparticles and protein nanoparticles

(2010) Petr Cigler et al.   NATURE MATERIALS

Single-molecule chemical reactions on DNA origami

(2010) Niels V. Voigt et al.   Nature Nanotechnology

Organizing protein–DNA hybrids as nanostructures with programmed functionalities

(2010) Carsten Teller et al.   TRENDS IN BIOTECHNOLOGY

Site Specific Conjugation of Fluoroprobes to the Remodeled Fc N-Glycans of Monoclonal Antibodies Using Mutant Glycosyltransferases: Application for Cell Surface Antigen Detection

(2009) Elizabeth Boeggeman et al.   BIOCONJUGATE CHEMISTRY

A Facile Method for Reversibly Linking a Recombinant Protein to DNA

(2009) Russell P. Goodman et al.   CHEMBIOCHEM

Site-specific covalent labeling of His-tag fused proteins with a reactive Ni(ii)–NTA probe

(2009) Sho-hei Uchinomiya et al.   CHEMICAL COMMUNICATIONS

Functional Nucleic Acid Sensors

(2009) Juewen Liu et al.   CHEMICAL REVIEWS

NTA Directed Protein Nanopatterning on DNA Origami Nanoconstructs

(2009) Wanqiu Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Immunomagnetic quantitative immuno-PCR for detection of less than one HIV-1 virion

(2009) Janet Barletta et al.   JOURNAL OF VIROLOGICAL METHODS

Enzyme cascades activated on topologically programmed DNA scaffolds

(2009) Ofer I. Wilner et al.   Nature Nanotechnology

Accommodation of a Single Protein Guest in Nanometer-Scale Wells Embedded in a “DNA Nanotape”

(2008) Akinori Kuzuya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MRI Detection of Thrombin with Aptamer Functionalized Superparamagnetic Iron Oxide Nanoparticles

(2008) Mehmet Veysel Yigit et al.   BIOCONJUGATE CHEMISTRY

Self-Assembled Donor Comprising Quantum Dots and Fluorescent Proteins for Long-Range Fluorescence Resonance Energy Transfer

(2008) Huachang Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Enzyme-Based E-DNA Sensor for Sequence-Specific Detection of Femtomolar DNA Targets

(2008) Gang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-assembled DNA nanostructures for distance-dependent multivalent ligand–protein binding

(2008) Sherri Rinker et al.   Nature Nanotechnology