The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling

OTUD1 Regulates Antifungal Innate Immunity through Deubiquitination of CARD9

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OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3

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Macrophage polarization in intestinal inflammation and gut homeostasis

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Breaking the chains: deubiquitylating enzyme specificity begets function

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Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD

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Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome

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Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders

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Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death

(2018) Ricard Garcia-Carbonell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative Splice Forms of CYLD Mediate Ubiquitination of SMAD7 to Prevent TGFB Signaling and Promote Colitis

(2018) Yilang Tang et al.   GASTROENTEROLOGY

Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases

(2018) Yue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Pediatric Inflammatory Bowel Disease

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Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system

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limma powers differential expression analyses for RNA-sequencing and microarray studies

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Macrophages in intestinal homeostasis and inflammation

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RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

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RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

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Inflammatory bowel disease: Pathogenesis

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Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease

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Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity

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A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation

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The complexity of NF-κB signaling in inflammation and cancer

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Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Bacteria and host interactions in the gut epithelial barrier

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Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis

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The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

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Role of NF-κB activation in intestinal immune homeostasis

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Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation

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Shared Principles in NF-κB Signaling

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NF-κB in inflammatory bowel disease

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